2nd Edition

Interactions of the Immune and Skeletal Systems

Editors: Joseph Lorenzo Mark Horowitz Yongwon Choi Hiroshi Takayanagi Georg Schett
Hardcover ISBN: 9780128005712
eBook ISBN: 9780128006276
Imprint: Academic Press
Published Date: 5th October 2015
Page Count: 376
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Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.

This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.

Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis.

Key Features

  • Explains the intricate interaction between the immune system and bone
  • Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems
  • Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems


Academic, medical, and pharmaceutical researchers in bone biology, immunology, rheumatology, endocrinology, hematology, and periodontia

Table of Contents

  • List of Contributors
  • Foreword
  • Preface
  • Chapter 1: Overview: The Developing Field of Osteoimmunology
    • Abstract
  • Chapter 2: The Origins of the Osteoclast
    • Abstract
    • First descriptions of the osteoclast
    • Early controversies: are osteoclasts capable of bone resorption?
    • Early controversies: hematopoietic or mesenchymal origin of the osteoclast?
    • Osteoclast: a hematopoietic cell
    • Osteoclasts: cells of the myeloid lineage
    • Advancing the field: culturing osteoclasts in vitro
    • Identification of RANKL and OPG
    • Defining osteoclast precursors within myeloid cell development
    • Heterogeneity among osteoclasts
    • Origins of the osteoclast through the lens of evolution
    • Conclusions
    • Acknowledgments
  • Chapter 3: Trafficking of Osteoclast Precursors
    • Abstract
    • Introduction
    • A century-long search for the identity of osteoclast precursors
    • Intravital two-photon imaging of bone tissues
    • Osteoclast precursors are motile and circulate throughout the body
    • Guidance cues sensed by osteoclast precursors in bone marrow
    • S1P-dependent migratory control of osteoclast precursors
    • Differences between osteoclast precursor and mature osteoclast migration mechanisms
    • Control of osteoclast migration and function by Rho GTPases
    • Role of integrins in osteoclast precursor migration
    • Control of osteoclast precursor differentiation by GPCR-mediated inhibition of cell migration
    • Unanswered questions in osteoclast precursor trafficking and differentiation
  • Chapter 4: Osteoclast Biology: Regulation of Formation and Function
    • Abstract
    • Introduction
    • RANKL and RANK: an osteoclastogenic cytokine and its receptor


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About the Editor

Joseph Lorenzo

Dr. Lorenzo is Professor of medicine in the Division of Endocrinology and Metabolism and Director of Bone Biology Research at the University of Connecticut Health Center. He is a nationally renowned expert on bone remodeling and its effect on bone health.

Affiliations and Expertise

University of Connecticut Health Center, Farmington, CT, USA

Mark Horowitz

Dr. Horowitz is Professor of Orthopaedics and Rehabilitation at the Yale University School of Medicine. His research interests include the interactions between the skeletal, immune, and hematopoietic systems as they relate to normal and pathologic bone remodeling.

Affiliations and Expertise

Yale University School of Medicine, New Haven, CT, USA

Yongwon Choi

Dr. Choi is Professor of Pathology and Laboratory Medicine, University of Pennsylvania; Investigator, The Leonard and Marilyn Abramson Family Cancer Research Institute, Philadelphia, PA.

Affiliations and Expertise

University of Pennsylvania, Philadelphia, PA, USA

Hiroshi Takayanagi

Dr. Takayanagi is Professor in the Department of Cell Signaling, Tokyo Medical and Dental University. His group studies the mechanism of bone destruction in rheumatoid arthritis, which focuses on the regulation of osteoclasts by T cells. This interdisciplinary field, osteoimmunology, covers various research on shared mechanisms and interactions between immune and bone systems.

Affiliations and Expertise

Tokyo Medical and Dental University, Tokyo, Japan

Georg Schett

Affiliations and Expertise

University of Erlangen-Nuremberg, Germany