New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.

Key Features

* NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution * UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups * SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts


Animal and plant virologists working in research and teaching. Evolutionary biologists and ecologists. Experts in public health, disease surveillance and zoonotic viral disease.

Table of Contents

1. Early Replication: Origin and Evolution Peter Schuster and Peter F. Stadler 2. Structure and Evolution of Viroids Núria Duran-Vila, Santiago F. Elena, José-Antonio Daròs and Richard Flores 3. Mutation, Competition and Selection as Measured with Small RNA Molecules Christof K. Biebricher 4. Viral Quasispecies: Dynamics, Interactions and Pathogenesis Esteban Domingo, Cristina Escarmís, Luis Menéndez-Arias, Celia Perales, Mónica Herrera, Isabel S. Novella and John J. Holland 5. Comparative Studies of RNA Virus Evolution Edward C. Holmes 6. Nucleic Acid Polymerase Fidelity and Viral Population Fitness Eric Smidansky, Jamie J. Arnold and Craig E. Cameron 7. The complex Interactions of Viruses and the RNAi Machinery: A Driving Force in Viral Evolution Ronald P. van Rij and Raul Andino 8. The Role of the APOBEC3 Family of Cytidine Deaminases in Innate Immunity, G-to-A Hypermutation, and Evolution of Retroviruses Marie L. Santiago and Warner C. Greene 9. Lethal Mutagenesis J.J. Bull and C.O. Wilke 10. Evolution of dsDNA Tailed Phages Roger W. Hendrix 11. More about Plant Virus Evolution – Past, Present and Future Adrian Gibbs, Mark Gibbs, Kazusato Ohshima and Fernando García-Arenal 12. Mutant clouds and bottleneck events in plant virus evolution Marilyn J. Roossinck 13. Retrovirus Evolution Simon Wain-Hobson 14. Intra-host dynamics and evolution of HIV Infection Viktor Müller and Sebastian Bonhoeffer 15. The


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Academic Press
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About the editors

Esteban Domingo

Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zürich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biología Molecular "Servero Ochoa" in Madrid.

Affiliations and Expertise

Centro de Biologia Molecular Severo Ochoa, Madrid, Spain

Colin Parrish

Affiliations and Expertise

Cornell University, Ithaca, NY, USA

John Holland

Affiliations and Expertise

University of California, San Diego, La Jolla, USA


Review of the previous edition: "...this a detailed account of current thinking on virus evolution... Because of the diversity of subjects, this book gives an up to date picture of research in various fields of virology, and helps to tease out connections between these fields. The subjects covered are essential reading for virologists but also have direct relevance for molecular biologists, and indeed any researchers with interests in early evolution... This publication is highly recommended for its breadth of coverage and detailed treatments of the various subjects"--TODAY'S LIFE SCIENCE (February 2001)