Origin and Evolution of Viruses

Origin and Evolution of Viruses

1st Edition - June 25, 1999

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  • Editors: Esteban Domingo, Robert Webster, John Holland
  • eBook ISBN: 9780080538235

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Are infectious diseases caused by novel entities, viruses that have rapidly evolved into more pathogenic forms, or viruses that have crossed species divides and become more virulent in their alternative host? These questions and how new diseases such as AIDS emerged have prompted renewed interest in the ways viruses originated and co-evolved with their hosts.Origin and Evolution of Viruses presents a full and clear description of general viral concepts and specific viral systems, and provides an excellent foundation to our understanding of how viruses emerged.This unique and comprehensive work is essential reading for all researchers in virology, molecular biology and related areas, as well as evolutionary biologists interested in phylogenetic approaches to molecular evolution. The reader is taken on an illumination journey--in time and concepts--from the first primitive replicons to their present-day complex viral counterparts. Apart from the obvious interest, as humans are potential hosts for these viruses, there is also a great deal of academic interest in the evolutionary aspects of this simple group of organisms, since information can be gained about the origin of stains/species and evolutionary patterns that might be applicable to higher species.

Key Features

@introbul:The book addresses:
@bul:* Nature and evolution of early replicons
* DNA and RNA viruses in both plants and animals
* Viral origin, mutation, and survival
* Antigenic variation in influenza virus
* Interplay between host evolution and DNA virus evolution
* Emergence of viral-induced diseases, e.g. hepatitis, influenza and HIV


Researchers in virology, molecular biology, and evolutionary biology interested in phylogenetic approaches to molecular evolution.

Table of Contents

  • P. Schuster and P.F. Stadler, Nature and Evolution of Early Replicons.
    H.D. Robertson and O.D. Neel, Virus Origins: Conjoined RNA Genomes as Precursors to DNA Genomes.
    J.S. Semancik and N. Duran-Vila, Viroids in Plants: Shadows and Footprints of a Primitive RNA.
    C. Biebricher, Mutation, Competition, and Selection as Measured with Small RNA Molecules.
    A. Meyerhans and J.-P. Vartanian, The Fidelity of Cellular and Viral Polymerases and Its Manipulation for Hypermutagenesis.
    S. Wain-Hobson and M. Sala, Drift and Conservatism in RNA Virus Evolution: Are They Adapting or Merely Changing?
    E. Domingo, C. Escarmís, L. Menéndez-Aarias, and J.J. Holland, Viral Quasispecies and Fitness Variations.
    M.A. McClure, The Retroid Agents: Disease, Function, and Evolution.
    D. Wodarz and M.A. Nowak, Dynamics of HIV Pathogenesis and Treatment.
    I.M. Rouzine and J.M. Coffin, Interplay between Experiment and Theory in Development of a Working Model for HIV-1 Population Dynamics.
    A.J. Gibbs, P.L. Keese, M.J. Gibbs, and F. García-Arenal, Plant Virus Evolution: Past, Present, and Future.
    M. Gromeier, E. Wimmer, and A.E. Gorbalenya, Genetics, Pathogenesis, and Evolution of Picornaviruses.
    J.I. Esteban, M. Martell, W.F. Carman, and J. Gómez, The Impact of Rapid Evolution of the Hepatitis Viruses.
    R.G. Webster, Antigenic Variation in Influenza Viruses.
    L.P. Villarreal, DNA Virus Contribution to Host Evolution.
    C.R. Parrish and U. Truyen, Parvovirus Variation and Evolution.
    D.J. McGeoch and A.J. Davison, The Molecular Evolutionary History of the Herpesviruses.
    J. Salas, M.L. Salas, and E. Viñuela, African Swine Fever Virus: A Missing Link Between Poxviruses and Iridoviruses?
    Subject Index.

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 1999
  • Published: June 25, 1999
  • Imprint: Academic Press
  • eBook ISBN: 9780080538235

About the Editors

Esteban Domingo

Esteban Domingo
Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zürich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biología Molecular "Servero Ochoa" in Madrid.

Affiliations and Expertise

Centro de Biologia Molecular Severo Ochoa, Madrid, Spain

Robert Webster

Dr. Robert Webster has worked in the field of Virology for over 30 years, first in New Zealand and then at the John Curtin School of Medical Research in Australia. He has spent the past 25 years at St. Jude Children’s Research Hospital in the Department of Virology & Molecular Biology. In addition to his position as Chairman at St. Jude, Dr. Webster is Director of the U.S. Collaborating Center of the World Health Organization dealing with the ecology of animal influenza viruses. He has served on numerous national and international advisory boards and is a Fellow of the Royal Society. Dr. Webster has published extensively on influenza in areas covering the origin of pandemic strains, genetic variation, structure and function of virus and, in conjunction with Graeme Laver, was responsible for the development of influenza subunit vaccines.

Affiliations and Expertise

St. Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.

John Holland

Affiliations and Expertise

University of California, San Diego, U.S.A.

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