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Organotransition Metals in Organic Synthesis - 1st Edition - ISBN: 9780128184776

Organotransition Metals in Organic Synthesis

1st Edition

Fundamentals and Applications

Author: Sugata Chatterjee
Paperback ISBN: 9780128184776
Imprint: Elsevier
Published Date: 1st November 2021
Page Count: 315
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Organotransition Metals in Organic Synthesis: Fundamentals and Applications provides a fundamental understanding on how to use transition and main group metals to synthesize simple and complex molecules with a high degree of selectivity. This book details the basic concepts, elementary reactions, and latest developments of organometallic chemistry surrounding the transition metals. Topics covered include electronic configuration and structural, methods for carbon-transition metal bond creation, cleavage of metal-carbon bonds to form new carbon-carbon bonds, chemo-, region-, stereo- and enantio- control, and heterogeneous organometallic reactions.

This book is an ideal resource for researchers and students working with metals in organic synthesis and organometallic chemistry, including those having no prior exposure to organometallic chemistry in synthesis.

Key Features

  • Includes extensive coverage of methods for creating carbon-transition metal bonds, such as oxidative addition, oxidative coupling, hydro and carbometallation, carbonyl insertion, transmetallation and metal carbenes and metathesis
  • Ideal for students and researchers new to the pharmaceutical industry or organometallic chemistry in general, covering foundational information as well as select advanced applications
  • Covers metals in organic synthesis, unprecedented selectivity, clean reactions, mild conditions, high yields, along with improvisation methods for existing synthesis methods


Researchers working with metals in organic synthesis, including those having no prior exposure to organometallic chemistry in synthesis

Table of Contents

  1. Introduction
    2. Electronic Configuration and Structural formalism (18e rule)
    3. Methods to make carbon-transition metal bond
    3a. Oxidative addition
    3b. Oxidative coupling
    3c. Hydro and carbometallation
    3d. Carbonyl insertion
    3e. Transmetallation
    3f. Metal carbenes and metathesis
    4. Cleavage of metal-carbon bonds to form new carbon-carbon bond in a highly selective fashion
    5. Chemo, regio, stereo and enantio control
    6. Heterogeneous organometallic reaction
    7. Selected applications


No. of pages:
© Elsevier 2021
1st November 2021
Paperback ISBN:

About the Author

Sugata Chatterjee

Sugata Chatterjee earned his doctoral thesis (1979 – 1984) under Nobel Laureate (2010) Professor E. Negishi at Purdue University on palladium catalyzed cross coupling (in particular allylation). He was Dr. Negishi’s teaching assistant for six semesters in advanced organometallic synthesis and intermediate organic chemistry. During his industrial research career at Hoechst (now Sanofi-Aventis), Merck, Wyeth, Lupin, and Dai-ichi, he has used synthetic organometallic chemistry extensively and with success.

Affiliations and Expertise

Department of Chemistry, Purdue University, West Lafayette, Indiana, USA

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