Organophosphorus Poisons - 1st Edition - ISBN: 9781483196770, 9781483221809

Organophosphorus Poisons

1st Edition

Anticholinesterases and Related Compounds

Authors: D. F. Heath
Editors: P. Alexander Z. M. Bacq
eBook ISBN: 9781483221809
Imprint: Pergamon
Published Date: 1st January 1961
Page Count: 412
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Modern Trends in Physiological Sciences, Volume 13: Organophosphorus Poisons: Anticholinesterases and Related Compounds covers the reactions, toxic action, activation, methods of preparation, and pharmacology of pentacovalent phosphorus compounds. This book is composed of four parts encompassing 17 chapters. The first part highlights the chemical aspects of organophosphorus poisons. This part specifically surveys their nomenclature, electronic theory, methods of preparation and purification, and hydrolytic and related reactions. The second part deals with the biochemical aspects of the compounds. Topics covered in this aspect include enzyme inhibition activity and metabolism in insects, mammals, plants, and soil. The third and fourth parts focus on the pharmacological aspects of organophosphorus poisons in mammals and insects. These parts emphasize some aspects of nerve function, of how nerve function is influenced by various drugs, and the main experimental set-ups used in studying the pharmacology of phosphorus compounds. A chapter on the therapeutic methods, symptoms, and diagnosis of their bad and abnormal effects in man is also provided.
This book is of value to pharmacologists, biochemists, physical chemists, and toxicologists.

Table of Contents


Introductory Chapter

Part I. Chemistry

I. Types of Compound, Nomenclature and Electronic Theory

II. Methods of Preparation

III. Chemical Reactions and Methods of Purification

IV. Hydrolytic and Related Reactions

Part II. Biochemistry

V. Some Enzymes

VI. The Inhibition of Enzymes by Phosphorus Compounds In Vitro

VII. Metabolism of Phosphorus Compounds In Vitro

VIII. Inhibition of Enzymes In Vivo

IX. Metabolism in Mammals and Insects

X. Metabolism in Plants and Soil

Part III. Pharmacology in Mammals

XI. Introductory Chapter

XII. Effects on Isolated Organs In Vitro

XIII. Effects on Partly Isolated Organs In Vivo

XIV. Effects on Mammals

XV. Therapeutic Methods; and Symptoms, Diagnosis and Therapy in Man

XVI. Abnormal Effects

Part IV. Pharmacology in Insects

XVII. Pharmacology in Insects



Subject Index

Formula Index


No. of pages:
© Pergamon 1961
eBook ISBN:

About the Author

D. F. Heath

About the Editor

P. Alexander

Z. M. Bacq

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