Organophosphorus Poisons

Organophosphorus Poisons

Anticholinesterases and Related Compounds

1st Edition - January 1, 1961

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  • Author: D. F. Heath
  • eBook ISBN: 9781483221809

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Modern Trends in Physiological Sciences, Volume 13: Organophosphorus Poisons: Anticholinesterases and Related Compounds covers the reactions, toxic action, activation, methods of preparation, and pharmacology of pentacovalent phosphorus compounds. This book is composed of four parts encompassing 17 chapters. The first part highlights the chemical aspects of organophosphorus poisons. This part specifically surveys their nomenclature, electronic theory, methods of preparation and purification, and hydrolytic and related reactions. The second part deals with the biochemical aspects of the compounds. Topics covered in this aspect include enzyme inhibition activity and metabolism in insects, mammals, plants, and soil. The third and fourth parts focus on the pharmacological aspects of organophosphorus poisons in mammals and insects. These parts emphasize some aspects of nerve function, of how nerve function is influenced by various drugs, and the main experimental set-ups used in studying the pharmacology of phosphorus compounds. A chapter on the therapeutic methods, symptoms, and diagnosis of their bad and abnormal effects in man is also provided. This book is of value to pharmacologists, biochemists, physical chemists, and toxicologists.

Table of Contents

  • Foreword

    Introductory Chapter

    Part I. Chemistry

    I. Types of Compound, Nomenclature and Electronic Theory

    II. Methods of Preparation

    III. Chemical Reactions and Methods of Purification

    IV. Hydrolytic and Related Reactions

    Part II. Biochemistry

    V. Some Enzymes

    VI. The Inhibition of Enzymes by Phosphorus Compounds In Vitro

    VII. Metabolism of Phosphorus Compounds In Vitro

    VIII. Inhibition of Enzymes In Vivo

    IX. Metabolism in Mammals and Insects

    X. Metabolism in Plants and Soil

    Part III. Pharmacology in Mammals

    XI. Introductory Chapter

    XII. Effects on Isolated Organs In Vitro

    XIII. Effects on Partly Isolated Organs In Vivo

    XIV. Effects on Mammals

    XV. Therapeutic Methods; and Symptoms, Diagnosis and Therapy in Man

    XVI. Abnormal Effects

    Part IV. Pharmacology in Insects

    XVII. Pharmacology in Insects



    Subject Index

    Formula Index

Product details

  • No. of pages: 412
  • Language: English
  • Copyright: © Pergamon 1961
  • Published: January 1, 1961
  • Imprint: Pergamon
  • eBook ISBN: 9781483221809

About the Author

D. F. Heath

About the Editors

P. Alexander

Z. M. Bacq

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