Organometallic Compounds and Living Organisms - 1st Edition - ISBN: 9780126860801, 9780323157650

Organometallic Compounds and Living Organisms

1st Edition

Authors: John Thayer
eBook ISBN: 9780323157650
Imprint: Academic Press
Published Date: 1st February 1984
Page Count: 286
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Organometallic Compounds and Living Organisms provides information pertinent to the fundamental aspects of organometallic compounds and living organisms. This book discusses the biological effects of organometallic compounds.

Organized into 10 chapters, this book begins with an overview of the recognition of methylmercuric compounds as the causative agents of Minamata disease, which has generated intensive research of their toxic effects. This text then examines the number of investigative applications of the biological inertness of silicones. Other chapters consider the capacity of many organometals to deactivate enzymes, which makes these compounds very useful for studying the nature of the enzyme active site. This book discusses as well the use and preparation of organometallurium compounds as imaging agents. The final chapter deals with the formation and cleavage of metal(loid)–carbon bonds, which play significant roles in the environmental transformation and circulation of metal(loids).

This book is a valuable resource for chemists.

Table of Contents


1. Historical Aspects

I. Some Basic Concepts

II. Early Chemotherapeutic Uses

III. Early Work in Organometal Toxicology


2. Medicinal and Pharmaceutical Applications

I. Introduction

II. Organometallic Compounds as Antibiotics

III. Therapeutic Applications

IV. Silicones as Prosthetic Agents


3. Toxicology of Organometallic Compounds

I. Introduction

II. Quantitative Toxicity Studies

III. Mechanisms of Toxicity

IV. Antidotes to Organometal Poisoning


4. Applications to Biochemical Investigations

I. Introduction

II. Chemical Investigations

III. Biological Investigations


5. Organometallic Compounds and Microorganisms

I. Introduction

II. Toxicological Investigations

III. Bacterial Metabolism of Organometals

IV. Other Microorganisms


6. Organometallic Compounds and Fungi and Algae

I. Introduction

II. Toxicological Investigations

III. Fungicidal Organometals in Agriculture

IV. Organometals as Surface Protectants

V. Investigations on Fungicidal Organometals


7. Organometallic Compounds and Plants

I. Introduction

II. Plant Growth Regulators

III. Weed Control Agents

IV. Investigations on the Interactions of Organometals with Plants


8. Organometallic Compounds and Animals

I. Introduction

II. Land Invertebrates

III. Aquatic Invertebrates

IV. Vertebrates


9. Biological Alterations of Metal-Carbon Bonds

I. Introduction

II. Biological Methylation

III. Biological Alkylation

IV. Biological Cleavage of Metal-Carbon Bonds

V. Enzymatic Hydroxylation of Organometallic Compounds


10. Organometallic Compounds in the Environment

I. Introduction

II. Environmental Transformations of Organometals

III. Biological Transport of Organometals

IV. Environmental Cycles Involving Organometals


Index to Chemical Substances

Index to Organisms

Subject Index


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© Academic Press 1984
Academic Press
eBook ISBN:

About the Author

John Thayer

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