Organisation of Chromosomes - 1st Edition - ISBN: 9780124105232, 9780124105447

Organisation of Chromosomes, Volume 90

1st Edition

Serial Editors: Rossen Donev
eBook ISBN: 9780124105447
Hardcover ISBN: 9780124105232
Imprint: Academic Press
Published Date: 29th April 2013
Page Count: 264
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Table of Contents

Preface

Chapter One. Large Tandem Repeats Make up the Chromosome Bar Code: A Hypothesis

1 Introduction

2 Satellite DNA in the Mouse Genome

3 Tandem Repeat Position Defined by FISH

4 “Bar Code” Hypothesis

Chapter Two. Mammalian Satellite DNA: A Speaking Dumb

1 Introduction

2 Heterochromatin Criteria

3 The Constitutive HC DNA

4 Transcription of HC DNA

5 Functions of Centromeric and Pericentromeric HC DNA Transcription

6 Conclusions

Chapter Three. Zinc Finger Proteins and the 3D Organization of Chromosomes

1 The 3D Organization of the Genome and Loops

2 CTCF and its Role in the 3D Genome Organization

3 A Model for CTCF

4 A Model for CTCF Binding

5 A Method to Compute Similarity for Unstructured Proteins

6 Discussion and Outlook

Chapter Four. Dynamics of Modeled Oligonucleosomes and the Role of Histone Variant Proteins in Nucleosome Organization

1 Introduction

2 Role of H2A.Z in the Dynamics of Modeled Oligonucleosomes

3 Conclusions and Outlook

Chapter Five. Unconventional Actin Configurations Step into the Limelight

1 Introduction

2 Structural Organization of Actin

3 Tools to Study Actin Localization, Arrangement, and Conformation

4 There is More Than F- and G-Actin in Eukaryotic Cells

5 Unconventional Actin Contacts

6 Conclusion

Chapter Six. Chromatin Reorganization Through Mitosis

1 Packaging the Genome

2 The Mitotic Chromosome

3 Specialized Mitotic Chromatin

4 Gene Bookmarking

5 Going Back to Interphase: Chromosome Decondensation

Author Index

Subject Index


Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

Key Features

  • Covers reviews of methodology and research in all aspects of protein chemistry
  • Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists


Details

No. of pages:
264
Language:
English
Copyright:
© Academic Press 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780124105447
Hardcover ISBN:
9780124105232

Reviews

"The authority, originality, and editing of the reviews are first class." --Nature

Ratings and Reviews


About the Serial Editors

Rossen Donev

Rossen Donev Serial Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Senior Lecturer in Swansea University. Currently he is Head of Research at MicroPharm Ltd, UK and Director of Biomed Consult, UK. He has published more than 60 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on design of antibody-based oral treatment of pathological conditions of the colon and small intestines.

Affiliations and Expertise

Swansea University, UK