Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition - 2nd Edition - ISBN: 9780126437317, 9780080513362

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

2nd Edition

Print ISBN: 9780126437317
eBook ISBN: 9780080513362
Imprint: Academic Press
Published Date: 28th February 2002
Page Count: 800
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The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.

This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Key Features

Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style


Upper division undergraduate and graduate students in the fields of chemistry (organic and medicinal) and biochemistry. Industrial chemists working on the design of enzyme inhibitors in the pharmaceutical and agricultural industries.

Table of Contents

Enzymes as Catalysts I. What Are Enzymes, and How Do They Work? II. Mechanisms of Enzyme Catalysis III. Enzyme Catalysis in Organic Media IV. Enzyme Nomenclature V. Epilogue References Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation I. Hydrolysis Reactions II. Aminations III. Phosphorylations: Transfers of Phosphate and Phosphate Esters to Water or Other Acceptors References Reduction and Oxidation I. General II. Redox without a Coenzyme III. Redox Reactions That Require Coenzymes References Monooxygenation I. General II. Flavin-Dependent Hydroxylases III. Pterin-Dependent Hydroxylases IV. Heme-Dependent Monooxygenases V. Nonheme Iron Oxygenation VI. Copper-Dependent Oxygenation References Dioxygenation I. General II. Intramolecular Dioxygenases III. Intermolecular Dioxygenases References Substitutions I. SN1 II. SN1/SN2 III. SN2 IV. SN29 V. SNAr: Nucleophilic Aromatic Substitution VI. Electrophilic Substitution (Addition/Elimination) VII. Electrophilic Aromatic Substitution References Carboxylations I. General Concepts II. Carbon Dioxide as the Carboxylating Agent III. Bicarbonate as the Carboxylating Agent References Decarboxylation


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© Academic Press 2002
Academic Press
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Praise for the First Edition "Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ... His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated ... should quickly become the standard for mechanistic studies." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY