Orexin/Hypocretin System

Orexin/Hypocretin System

1st Edition - July 27, 2012
This is the Latest Edition
  • Editor: Anantha Shekhar
  • Hardcover ISBN: 9780444594891
  • eBook ISBN: 9780444594907

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Description

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

  • Series Page

    List of Contributors

    Preface

    Chapter 1. Many faces of orexin/hypocretin

    Chapter 2. Overview of orexin/hypocretin system

    Introduction

    Discovery of orexin/hypocretin

    Loss of orexin signaling causes narcolepsy

    Orexin neurons as stabilizer of sleep/wakefulness states

    Integrative physiology of orexin system

    Clinical perspectives

    Chapter 3. Hypocretins and the neurobiology of sleep–wake mechanisms

    Introduction

    Discovery and properties of the hypocretins

    Loss of function

    Hypocretin neuronal activity

    Arousal circuits modulated by the hypocretins

    The hypocretins as an integrator circuit in arousal

    Chapter 4. Respiration and autonomic regulation and orexin

    Introduction

    Orexins and breathing

    Orexins and blood pressure

    Orexins and thermoregulation

    Development of the orexin system

    Concluding remarks

    Chapter 5. Orexins, feeding, and energy balance

    Introduction

    Functional neuroanatomy of the orexin system

    Activity of orexin neurons

    Orexin neurons and regulation of food intake

    Orexin and regulation of energy homeostasis

    Effects of orexin on autonomic nervous system

    Concluding remarks

    Chapter 6. Orexin and natural reward

    Introduction

    Orexin, feeding, and energy homeostasis

    Orexin and food motivation and reward

    Orexin and other naturally rewarding behaviors

    Orexin and maternal behavior

    Orexin and sexual performance and motivation

    Orexin and sexual reward

    Conclusions

    Chapter 7. Multiple roles for orexin/hypocretin in addiction

    Introduction and overview

    Animal models of addiction

    Orexin roles in drug seeking

    Brain circuits underlying orexin modulation of drug seeking

    Behavioral pharmacology of orexin

    Reconciling orexin’s roles in appetitive motivation versus stress

    Future directions and clinical usefulness of modulating orexin

    Chapter 8. Hypocretin modulation of drug-induced synaptic plasticity

    Introduction

    Reciprocal innervation of the hypocretin and dopamine systems

    Hypocretin-1 and synaptic plasticity in the mesolimbic dopamine system

    Hypocretin-2 and plasticity of the mesolimbic dopamine system

    Hypocretin-1 and drug-induced synaptic plasticity of VTA dopamine neurons

    Drug-induced plasticity of hypocretin neurons

    Conclusions and future directions

    Note added in Proof

    Chapter 9. Orexin, stress, and anxiety/panic states

    Orexin/hypocretin discovery and loss of function linked to narcolepsy

    Neuroanatomical evidence supporting a role for orexin/hypocretin involvement in anxiety and panic

    Orexin role in mobilizing an integrative anxiety–panic response

    Translational studies linking a hyperactive ORX system to anxiety and panic states

    Concluding remarks

    Chapter 10. Orexin receptors as therapeutic drug targets

    Introduction: A model for the development of targeted small-molecule CNS therapies

    Pharmacology of orexin neuropeptides and their receptors

    Therapeutic opportunities for orexin receptor modulators

    Discovery of selective and dual orexin receptor antagonists and agonists

    Concluding remarks

    Subject Index

    Volume in series

Product details

  • No. of pages: 208
  • Language: English
  • Copyright: © Elsevier 2012
  • Published: July 27, 2012
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444594891
  • eBook ISBN: 9780444594907

About the Serial Volume Editor

Anantha Shekhar

Anantha Shekhar, MD, PhD, is a distinguished professor of psychiatry, neurobiology and pharmacology at Indiana University and holds the August M. Watanabe Chair of Medical Research, Professor of Psychiatry. He has been continuously funded by the National Institutes of Health for his basic, clinical and translational research since 1989. Dr. Shekhar leads a successful basic and clinical research programs in the areas of stress, anxiety and neuropsychiatric disorders. A number of grants from the National Institutes of Health, private foundations, and commercial collaborations currently support his research. He has authored over 200 peer reviewed publications. He has received several university and national awards and has been a member and chair of several NIH study sections. He has also served as a member of the Board of Scientific Advisors for the National Institute of Mental Health. He has served as the president of the Society of Clinical and Translational Sciences and the president of the Association for Clinical and Translational Sciences. He currently serves as a member of the Advisory Council for National Center for Advancing Translation Sciences (NCATS) of the NIH and a member of the Board of Governors for the Cures Acceleration Network (CAN) at the NIH.

Affiliations and Expertise

Director, Indiana Clinical and Translational Sciences Institute, Distingushed Professor and Executive Associate Dean for Research Affairs, Indiana University School of Medicine