Tools for Controlling and Monitoring Neuronal Activity

1st Edition - March 1, 2012
This is the Latest Edition
  • Editors: Thomas Knopfel, Edward S. Boyden
  • Hardcover ISBN: 9780444594266
  • eBook ISBN: 9780444594457

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Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist


Neuroscientists, psychologists, neurologists

Table of Contents

    1. A comprehensive concept of optogenetics
    2. Guillaume P. Dugué, Walther Akemann, and Thomas Knöpfel

    3. Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants
    4. John Y. Lin

    5. Genetically encoded molecular tools for light-driven silencing of targeted neurons
    6. Brian Y. Chow, Xue Han, and Edward S. Boyden

    7. Genetically encoded probes for optical imaging of brain electrical activity
    8. Amelie Perron, Walther Akemann, Hiroki Mutoh and Thomas Knöpfel

    9. Neural activity imaging with genetically encoded calcium indicators
    10. Lin Tian, Jasper Akerboom, Eric R. Schreiter, and Loren L. Looger

    11. Manipulating cellular processes using optical control of protein-protein interactions
    12. Chandra L. Tucker

    13. Two-photon optogenetics
    14. Dan Oron, Eirini Papagiakoumou, F. Anselmi, and Valentina Emiliani

    15. Zebrafish as an appealing model for optogenetic studies
    16. Joshua Simmich, Eric Staykov, and Ethan Scott

    17. Genetic targeting of specific neuronal cell types in the cerebral cortex
    18. Alan Urban, and Jean Rossier

    19. Mouse transgenic approaches in optogenetics
    20. Hongkui Zeng, and Linda Madisen

    21. Optogenetics in the nonhuman primate
    22. Xue Han

    23. Optogenetic Reporters: Fluorescent Protein-Based Genetically-Encoded Indicators of Signaling and Metabolism in the Brain

      Mathew Tantama, Yin Pun Hung,and Gary Yellen

Product details

  • No. of pages: 288
  • Language: English
  • Copyright: © Elsevier 2012
  • Published: March 1, 2012
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444594266
  • eBook ISBN: 9780444594457

About the Serial Volume Editors

Thomas Knopfel

Edward S. Boyden