1. Introduction. Chromatography. Separation - the column. Resolution. Efficiency. Optimization. Peak capacity. Method development. 2. Selection of Methods. Classification of chromatographic techniques. Selection of chromatographic methods. Characterization and classification methods. 3. Parameters Affecting Selectivity. GC. LC. Separation of ions in LC. Supercritical fluid chromatography. Classification of parameters. 4. Optimization Criteria. Introduction. Elemental criteria. Chromatograms. Composite criteria. Recommended criteria for the general case. Specific problems. 5. Optimization Procedures. Introduction. Simultaneous methods without solute recognition. The simplex method. Reduction of the parameter space. Interpretive methods. Peak assignment and recognition. Summary. 6. Programmed Analysis. The application of programmed analysis. Parameters affecting selectivity in programmed analysis. Optimization of programmed analysis. 7. System Optimization. Introduction. Efficiency optimization. Sensitivity optimization. Instrument optimization. List of symbols and abbreviations. Author Index. Subject Index. (All chapters include references).