Opioid Peptides: Biology, Chemistry, and Genetics

Opioid Peptides: Biology, Chemistry, and Genetics

The Peptides: Analysis, Synthesis, Biology, Vol. 6

1st Edition - November 12, 1984

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  • Editors: Sidney Udenfriend, Johannes Meienhofer
  • eBook ISBN: 9781483217994

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The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.

Table of Contents

  • Contributors



    Nomenclature and Abbreviations

    Structures of Opiates and Related Nonpeptide Receptor Ligands Discussed in the Text

    Opioid Peptides with Special Names

    Contents of Previous Volumes

    Chapter 1 Opioid Peptide Precursors and Their Genes

    I Introduction

    II Cloning of cDNAs for Opioid Peptide Precursors

    III Nucleotide Sequences of mRNAs Encoding Opioid Peptide Precursors and Assignment of Protein Sequences

    IV Cloning and Structural Analysis of Opioid Peptide Precursor Genes

    V Regulation of Gene Expression

    VI Biological Significance of Multihormone Precursors

    VII Concluding Remarks


    Chapter 2 Proenkephalin and the Products of Its Processing: Chemistry and Biology

    I Introduction

    II Methodology

    III Isolation and Characterization of Enkephalin-Containing Peptides

    IV Conclusions from Peptide and Protein Chemistry

    V Molecular Biology

    VI Evidence for Posttranslational Modifications

    VII Distributions of Proenkephalin and Its Products

    VIII Biological Considerations

    IX Regulation of Proenkephalin Biosynthesis

    X Processing of Proenkephalin

    XI Concluding Remarks


    Chapter 3 Pro-opiomelanocortin: A Polyprotein at the Interface of Endocrine and Nervous Systems

    I Introduction

    II Structure of the Pro-opiomelanocortin (POMC) Polypeptide Precursor and Its Corresponding Gene

    III Regulation of Pro-opiomelanocortin-Derived Peptide Production

    IV Posttranslation Regulation of Production of Pro-opiomelanocortin-Derived Peptide

    V Conclusion


    Chapter 4 Biology and Chemistry of the Dynorphin Peptides

    I History

    II Distribution

    III The Dynorphin (Kappa Opioid) Receptor

    IV Possible Physiologic Functions

    V Prospects


    Chapter 5 Opioid Receptors

    I Introduction

    II Heterogeneity of Opioid Receptors

    III Endogenous Opioid Peptides

    IV Isolation of Opioid Receptors

    V Conclusions


    Chapter 6 ß-Endorphin: Structure and Activity

    I Introduction

    II Synthesis of ß-Endorphin and Its Analogs

    III Biological Characterization

    IV Structure-Activity Relationships in ß-Endorphins

    V Concluding Remarks


    Chapter 7 Conformational Analysis of Enkephalin and Conformation-Activity Relationships

    I Introductory Remarks

    II Conformational Models of Enkephalin Based on Structural Comparison with Opiates

    III Theoretical Energy Calculations

    IV Crystal Structure Determinations

    V Conformational Studies in Solution

    VI Conformationally Restricted Enkephalin Analogs

    VII Conclusion


    Chapter 8 Structure-Activity Relationships in Enkephalin Peptides

    I Introduction

    II Structure-Activity Relationships

    III Conclusion


    Chapter 9 Opioid Peptides in Humans and Their Clinical Significance

    I Introduction

    II Strategies Used in the Study of the Clinical Significance of Endogenous Opioid Peptides

    III Distribution of Opioid Peptides in Humans

    IV Possible Physiological and Pathophysiological Roles of Opioid Peptides

    V Conclusion and Future Prospects



Product details

  • No. of pages: 446
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: November 12, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9781483217994

About the Editors

Sidney Udenfriend

Johannes Meienhofer

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