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Opioid Peptides: Biology, Chemistry, and Genetics - 1st Edition - ISBN: 9780123042064, 9781483217994

Opioid Peptides: Biology, Chemistry, and Genetics

1st Edition

The Peptides: Analysis, Synthesis, Biology, Vol. 6

Editors: Sidney Udenfriend Johannes Meienhofer
eBook ISBN: 9781483217994
Imprint: Academic Press
Published Date: 12th November 1984
Page Count: 446
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The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.

Table of Contents




Nomenclature and Abbreviations

Structures of Opiates and Related Nonpeptide Receptor Ligands Discussed in the Text

Opioid Peptides with Special Names

Contents of Previous Volumes

Chapter 1 Opioid Peptide Precursors and Their Genes

I Introduction

II Cloning of cDNAs for Opioid Peptide Precursors

III Nucleotide Sequences of mRNAs Encoding Opioid Peptide Precursors and Assignment of Protein Sequences

IV Cloning and Structural Analysis of Opioid Peptide Precursor Genes

V Regulation of Gene Expression

VI Biological Significance of Multihormone Precursors

VII Concluding Remarks


Chapter 2 Proenkephalin and the Products of Its Processing: Chemistry and Biology

I Introduction

II Methodology

III Isolation and Characterization of Enkephalin-Containing Peptides

IV Conclusions from Peptide and Protein Chemistry

V Molecular Biology

VI Evidence for Posttranslational Modifications

VII Distributions of Proenkephalin and Its Products

VIII Biological Considerations

IX Regulation of Proenkephalin Biosynthesis

X Processing of Proenkephalin

XI Concluding Remarks


Chapter 3 Pro-opiomelanocortin: A Polyprotein at the Interface of Endocrine and Nervous Systems

I Introduction

II Structure of the Pro-opiomelanocortin (POMC) Polypeptide Precursor and Its Corresponding Gene

III Regulation of Pro-opiomelanocortin-Derived Peptide Production

IV Posttranslation Regulation of Production of Pro-opiomelanocortin-Derived Peptide

V Conclusion


Chapter 4 Biology and Chemistry of the Dynorphin Peptides

I History

II Distribution

III The Dynorphin (Kappa Opioid) Receptor

IV Possible Physiologic Functions

V Prospects


Chapter 5 Opioid Receptors

I Introduction

II Heterogeneity of Opioid Receptors

III Endogenous Opioid Peptides

IV Isolation of Opioid Receptors

V Conclusions


Chapter 6 ß-Endorphin: Structure and Activity

I Introduction

II Synthesis of ß-Endorphin and Its Analogs

III Biological Characterization

IV Structure-Activity Relationships in ß-Endorphins

V Concluding Remarks


Chapter 7 Conformational Analysis of Enkephalin and Conformation-Activity Relationships

I Introductory Remarks

II Conformational Models of Enkephalin Based on Structural Comparison with Opiates

III Theoretical Energy Calculations

IV Crystal Structure Determinations

V Conformational Studies in Solution

VI Conformationally Restricted Enkephalin Analogs

VII Conclusion


Chapter 8 Structure-Activity Relationships in Enkephalin Peptides

I Introduction

II Structure-Activity Relationships

III Conclusion


Chapter 9 Opioid Peptides in Humans and Their Clinical Significance

I Introduction

II Strategies Used in the Study of the Clinical Significance of Endogenous Opioid Peptides

III Distribution of Opioid Peptides in Humans

IV Possible Physiological and Pathophysiological Roles of Opioid Peptides

V Conclusion and Future Prospects




No. of pages:
© Academic Press 1984
12th November 1984
Academic Press
eBook ISBN:

About the Editors

Sidney Udenfriend

Johannes Meienhofer

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