Opiate Receptors and the Neurochemical Correlates of Pain - 1st Edition - ISBN: 9780080263908, 9781483147888

Opiate Receptors and the Neurochemical Correlates of Pain

1st Edition

Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979

Editors: Susanna Fürst
eBook ISBN: 9781483147888
Imprint: Pergamon
Published Date: 1st January 1980
Page Count: 246
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Description

Opiate Receptors and the Neurochemical Correlates of Pain, Volume V, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The congress offered a good opportunity to stimulate discussions and exchange of ideas between scientists from various countries who approach the problem of narcotics and pain mechanisms in different ways. The 27 contributions in this volume have enriched knowledge in this rapidly expanding field of pharmacology. This volume begins with a discussion of opiate receptors. The results suggest the interaction of various morphine-like drugs with different opiate receptor populations. The existence in nerve tissue of specific opiate receptors binding morphine and other opioids has led to the assumption of endogenous ligand for opiate receptors. One section of the present volume is devoted to enkephalins and endorphins, their structure-activity relationships, interactions with transmitter and other systems, their behavioral effects, and to factors controlling their release. Some other aspects of nociception; the pathways involved in the mode of action of different types of analgesics, e.g. narcotics and non-narcotics; and their relations to inflammation and active substances, such as prostaglandins and substance P, are discussed from various aspects.

Table of Contents


Preface

I. Opiate Receptors

Opiate-A Receptors Relate to Cholinergic and Opiate-B Receptors to Catecholaminergic Neurons

Behavioral and Biochemical Studies on Azidomorphines. I. Behavioral Actions and Antagonism of Abstinence Syndromes

Behavioral and Biochemical Studies on Azidomorphines. II. Action on Opiate and Catecholamine Receptors

A New Model for the Study of Opiate Β Receptors: Isolated Splenic Strips of the Cat

Classification of Multiple Opiate Receptors Involved in Different Animal Tests

The Effects of Azidomorphines on the Opiate Receptor(s) of Guinea-Pig Ileum

In Vitro Studies on the Opiate Receptor Affinity of Fentanyl Analogues

Opiate Receptors in the Brain of Molluscs (Anodonta cygnea. Helix pomatia)

II. Opioid Peptides

Brain and Pituitary Opioid Peptides: Pharmacological Manipulation of Content and Release

In Vivo Active Enkephalin Analogues: Structure-Activity Relationships

Study on the Neuroleptic Activity of Endorphins

Behavioral Effects of a Potent Morphine-like Pentapeptide: (d-met2, pro5)-Enkephalinamide

The Influence of Some Peptides on Morphine Analgetic Effect

Are Plasma Levels of ß-Endorphin Correlated with Adaptation of Humans to Stress Situations?

Involvement of the Opioid Peptidergic System in Biological Responses of Adaptive Significance

Naloxone Enhances Peristalsis in the Guinea-Pig Small Intestine In Vitro. Influence on Different Parameters of Peristalsis

III. Factors Influencing the Actions of Opiates

Neurochemical Basis of Analgesia

Calcium Interactions in Opiate Analgesia, Tolerance and Physical Dependence

The Influence of Methadone Derivatives on the Isolated Myenteric Plexus-Longitudinal Muscle Preparation of the Guinea-Pig Ileum

New Data Concerning the Interaction between Cholinergic Enkephalinergic and Serotoninergic Systems during Analgesia

Effects of Morphine and Naloxone on Catecholamine and Dihydroxyphenyl-Acetic Acid (DOPAC) Content of Individual Brain Nuclei

The Interaction between Narcotic Analgesics and Monoamine Oxidase Inhibitors

The Role of Metabolic Factors in the Interaction between Opiates and Homopyrimidazols, in the Central Nervous System

The Influence of Opiate Antagonists on the Activity of Sensorimotor Cortical Neurons

IV. Neurotropic Activities and Inflammation

Substance Ρ and Pain Fibers

The Opioid Peptidergic System May Be Involved in the Control of Inflammatory Reactions

Comparison of the Analgetic Action of Inhibitors of PG Synthesis Chinoin-127 and Morphine

Subject Index

Details

No. of pages:
246
Language:
English
Copyright:
© Pergamon 1980
Published:
Imprint:
Pergamon
eBook ISBN:
9781483147888

About the Editor

Susanna Fürst