Opiate Receptors and the Neurochemical Correlates of Pain

Opiate Receptors and the Neurochemical Correlates of Pain

Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979

1st Edition - January 1, 1980

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  • Editor: Susanna Fürst
  • eBook ISBN: 9781483147888

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Description

Opiate Receptors and the Neurochemical Correlates of Pain, Volume V, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The congress offered a good opportunity to stimulate discussions and exchange of ideas between scientists from various countries who approach the problem of narcotics and pain mechanisms in different ways. The 27 contributions in this volume have enriched knowledge in this rapidly expanding field of pharmacology. This volume begins with a discussion of opiate receptors. The results suggest the interaction of various morphine-like drugs with different opiate receptor populations. The existence in nerve tissue of specific opiate receptors binding morphine and other opioids has led to the assumption of endogenous ligand for opiate receptors. One section of the present volume is devoted to enkephalins and endorphins, their structure-activity relationships, interactions with transmitter and other systems, their behavioral effects, and to factors controlling their release. Some other aspects of nociception; the pathways involved in the mode of action of different types of analgesics, e.g. narcotics and non-narcotics; and their relations to inflammation and active substances, such as prostaglandins and substance P, are discussed from various aspects.

Table of Contents


  • Preface

    I. Opiate Receptors

    Opiate-A Receptors Relate to Cholinergic and Opiate-B Receptors to Catecholaminergic Neurons

    Behavioral and Biochemical Studies on Azidomorphines. I. Behavioral Actions and Antagonism of Abstinence Syndromes

    Behavioral and Biochemical Studies on Azidomorphines. II. Action on Opiate and Catecholamine Receptors

    A New Model for the Study of Opiate Β Receptors: Isolated Splenic Strips of the Cat

    Classification of Multiple Opiate Receptors Involved in Different Animal Tests

    The Effects of Azidomorphines on the Opiate Receptor(s) of Guinea-Pig Ileum

    In Vitro Studies on the Opiate Receptor Affinity of Fentanyl Analogues

    Opiate Receptors in the Brain of Molluscs (Anodonta cygnea. Helix pomatia)

    II. Opioid Peptides

    Brain and Pituitary Opioid Peptides: Pharmacological Manipulation of Content and Release

    In Vivo Active Enkephalin Analogues: Structure-Activity Relationships

    Study on the Neuroleptic Activity of Endorphins

    Behavioral Effects of a Potent Morphine-like Pentapeptide: (d-met2, pro5)-Enkephalinamide

    The Influence of Some Peptides on Morphine Analgetic Effect

    Are Plasma Levels of ß-Endorphin Correlated with Adaptation of Humans to Stress Situations?

    Involvement of the Opioid Peptidergic System in Biological Responses of Adaptive Significance

    Naloxone Enhances Peristalsis in the Guinea-Pig Small Intestine In Vitro. Influence on Different Parameters of Peristalsis

    III. Factors Influencing the Actions of Opiates

    Neurochemical Basis of Analgesia

    Calcium Interactions in Opiate Analgesia, Tolerance and Physical Dependence

    The Influence of Methadone Derivatives on the Isolated Myenteric Plexus-Longitudinal Muscle Preparation of the Guinea-Pig Ileum

    New Data Concerning the Interaction between Cholinergic Enkephalinergic and Serotoninergic Systems during Analgesia

    Effects of Morphine and Naloxone on Catecholamine and Dihydroxyphenyl-Acetic Acid (DOPAC) Content of Individual Brain Nuclei

    The Interaction between Narcotic Analgesics and Monoamine Oxidase Inhibitors

    The Role of Metabolic Factors in the Interaction between Opiates and Homopyrimidazols, in the Central Nervous System

    The Influence of Opiate Antagonists on the Activity of Sensorimotor Cortical Neurons

    IV. Neurotropic Activities and Inflammation

    Substance Ρ and Pain Fibers

    The Opioid Peptidergic System May Be Involved in the Control of Inflammatory Reactions

    Comparison of the Analgetic Action of Inhibitors of PG Synthesis Chinoin-127 and Morphine

    Subject Index

Product details

  • No. of pages: 246
  • Language: English
  • Copyright: © Pergamon 1980
  • Published: January 1, 1980
  • Imprint: Pergamon
  • eBook ISBN: 9781483147888

About the Editor

Susanna Fürst

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