Oncogenomics
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Oncogenomics

From Basic Research to Precision Medicine

1st Edition - October 30, 2018

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  • Editors: Franco Dammacco, Francesco Silvestris
  • Paperback ISBN: 9780128117859
  • eBook ISBN: 9780128117866

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Description

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies.

Key Features

  • Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies
  • Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types
  • Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

Readership

Clinical oncologists, human geneticists, physicians, graduate students on oncology and genetics

Table of Contents

  • PART I: MOLECULAR MEDICINE: A NOVEL APPROACH TO CANCER INVESTIGATION
    1. FROM THE DOUBLE HELIX TO ONCOGENOMICS AND PRECISION CANCER MEDICINE: AN EVOLVING STORY
    Franco Dammacco and Franco Silvestris
    2. INTRATUMOR HETEROGENEITY: BIOLOGICAL AND CLINICAL IMPLICATIONS
    Rekha Gyanchandani, Nolan Priedigkeit, Ahmed Basudan and Adrian V. Lee
    3. THE ROLE OF PROTEOMICS IN CANCER RESEARCH
    Carolina Panis, Stephany Correˆa, Renata Binato and Eliana Abdelhay
    4. NEXT-GENERATION SEQUENCING IN CLINICAL PRACTICE
    Umberto Malapelle, Pasquale Pisapia, Francesco Passiglia, Amélie Dendooven, Patrick Pauwels, Roberto Salgado and Christian Rolfo
    5. CANCER EPIGENETICS: ABERRANT DNA METHYLATION IN CANCER DIAGNOSIS AND TREATMENT
    Hideyuki Takeshima, Harumi Yamada and Toshikazu Ushijima
    6. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE
    Farhadul Islam, Vinod Gopalan and Alfred King-Yin Lam
    7. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE
    Ahmad R. Safa
    8. TARGETING THE HEDGEHOG AND NOTCH SIGNALING PATHWAYS IN CANCER STEM CELLS
    Ankita Borah and D. Sakthi Kumar
    9. CANCER STEM CELLS IN MULTIPLE MYELOMA AND THE DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES
    Franco Dammacco, Patrizia Leone, Franco Silvestris, Vito Racanelli and Angelo Vacca

    PART II: ONCOGENOMICS: CIRCULATING BIOMARKERS IN CLINICAL ONCOLOGY
    10. BONE METASTASES FROM SOLID TUMORS: IN SEARCH OF PREDICTIVE BIOMARKERS FOR CLINICAL TRANSLATION
    Franco Silvestris, Stella D’Oronzo, Domenica Lovero, Raffaele Palmirotta and Franco Dammacco
    11. LIQUID BIOPSY AND GENOMIC ASSESSMENT FOR LUNG CANCER: THE ROLE IN CLINICAL PRACTICE?
    Véronique Hofman, Simon Heeke, Maryline Allègra, Marius Ilié and Paul Hofman
    12. PROGNOSTIC AND PREDICTIVE ROLE OF CIRCULATING TUMOR CELLS
    Francesco Schettini, Mario Giuliano and Massimo Cristofanilli
    13. CIRCULATING MIRNAS AS TUMOR BIOMARKERS
    Vikas Ghai, Inyoul Lee and Kai Wang
    14. CIRCULATING DNA IN CANCER DIAGNOSIS AND PROGNOSIS
    Eveline E. Vietsch and Anton Wellstein
    15. SEQUENCING A SINGLE CIRCULATING TUMOR CELL FOR GENOMIC ASSESSMENT
    Lei Xu, Nuria Coll Bastus and Yong-Jie Lu
    16. SINGLE NUCLEOTIDE POLYMORPHISMS IN CANCER RESEARCH AND TREATMENT
    Massimo Di Maio

    PART III: GASTROINTESTINAL TUMORS: MOLECULAR DIAGNOSIS AND TREATMENT
    17. GASTRIC CANCERS: A MOLECULAR ROADMAP FOR PATIENT STRATIFICATION AND TARGETED THERAPIES
    Maxime Chénard-Poirier and Elizabeth C. Smyth
    18. RESISTANCE TO EGFR TARGETING TREATMENTS IN COLORECTAL CANCER
    Michela Pucci and Mattia Lauriola
    19. CIRCULATING DNA AND PROTEIN BIOMARKERS FOR THE TREATMENT OF TYROSINE KINASE INHIBITORS IN METASTATIC COLORECTAL CANCER
    Kjetil Søreide
    20. RATIONALE FOR IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANCIES
    Vasiliki Michalarea and Elizabeth Smyth
    21. PROTEOMICS PROFILING OF PANCREATIC CANCER: ROLES IN BIOMARKER DISCOVERY
    Hong Peng, Ru Chen and Sheng Pan
    22. EMERGING TECHNOLOGIES FOR THE DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER
    Magdalena Swierczewska, Serguei Kozlov and Pavan P. Adiseshaiah
    23. PERSONALIZED MEDICINE IN GASTROINTESTINAL STROMAL TUMORS
    Margherita Nannini and Guido Biasco
    24. CIRCULATING MICRORNAS AS TUMOR BIOMARKERS IN HEPATOCELLULAR CARCINOMA
    Albrecht Piiper and Oliverwaidmann

    PART IV: PERSPECTIVES IN BREAST CANCER GENOMICS
    25. GENE PROFILES IN BREAST CANCER: TRANSLATION TO CLINICAL MEDICINE
    Serena Di Cosimo, Maria Grazia Daidone and Vera Cappelletti
    26. NOVEL BIOMARKERS PREDICTING THE DEVELOPMENT OF BONE METASTASIS IN EARLY BREAST CANCER
    Michele Iuliani, Paolo Manca, Giulia Ribelli, Sonia Simonetti, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini
    27. HER2-POSITIVE EARLY BREAST CANCER: AFFORDABLE RISKS, AFFORDABLE THERAPIES, AND NEW DEVELOPMENTS
    Pierfranco Conte, Mariavittoria Dieci, Graziavernaci and Valentina Guarneri
    28. ROLE OF CIRCULATING TUMOR CELLS IN BREAST CANCER PATIENTS
    Rita Lampignano, A.M. Sofie Berghuis, Tanja Fehm and Hans Neubauer
    29. OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER: MTOR INHIBITORS AND NEW DRUGS
    Paola Ferrari and Andrea Nicolini
    30. EXPLORE GENOMIC PROFILES FOR TRIPLE-NEGATIVE BREAST CANCER TO DISCOVER DRUG TARGETS
    Xiaosheng Wang
    46. BRAF-MUTANT MELANOMA: TREATMENT APPROACHES AND RESISTANCE MECHANISMS
    Svenja Meierjohann and Bastian Schilling

Product details

  • No. of pages: 718
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: October 30, 2018
  • Imprint: Academic Press
  • Paperback ISBN: 9780128117859
  • eBook ISBN: 9780128117866

About the Editors

Franco Dammacco

Franco Dammacco is Emeritus Professor of Internal Medicine at the University of Bari Medical School and has been President of the Italian Society of Internal Medicine. His research and clinical interests include HCV-related cryoglobulinemic vasculitis, onco-hematology, connective tissue diseases and immunodeficiency syndromes. He is author or co-author of more than 470 papers and Editor-in-Chief of the journal Clinical and Experimental Medicine.

Affiliations and Expertise

Emeritus Professor of Internal Medicine, University of Bari Medical School, Italy

Francesco Silvestris

Franco Silvestris is Full Professor of Internal Medicine and Clinical Oncology, and Director of the Post-Graduation Residency Course in Medical Oncology at the University of Bari Medical School. Also, he is Coordinator of the Doctorate in ‘Biomomecular Sciences in Pharmacology and Medicine’ at the same University, and Director of the ‘Oncogenomic Research Center’ at the University-Hospital ‘Policlinico’, Bari. He is author or co-author of more than 180 scientific articles in clinical and molecular medicine.

Affiliations and Expertise

Department of Internal Medicine and Clinical Oncology, University of Bari, Italy

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