Oncogenomics

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies.

• Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies
• Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types
• Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

Clinical oncologists, human geneticists, physicians, graduate students on oncology and genetics

PART I: MOLECULAR MEDICINE: A NOVEL APPROACH TO CANCER INVESTIGATION
1. FROM THE DOUBLE HELIX TO ONCOGENOMICS AND PRECISION CANCER MEDICINE: AN EVOLVING STORY
Franco Dammacco and Franco Silvestris
2. INTRATUMOR HETEROGENEITY: BIOLOGICAL AND CLINICAL IMPLICATIONS
Rekha Gyanchandani, Nolan Priedigkeit, Ahmed Basudan and Adrian V. Lee
3. THE ROLE OF PROTEOMICS IN CANCER RESEARCH
Carolina Panis, Stephany Correˆa, Renata Binato and Eliana Abdelhay
4. NEXT-GENERATION SEQUENCING IN CLINICAL PRACTICE
Umberto Malapelle, Pasquale Pisapia, Francesco Passiglia, Amélie Dendooven, Patrick Pauwels, Roberto Salgado and Christian Rolfo
5. CANCER EPIGENETICS: ABERRANT DNA METHYLATION IN CANCER DIAGNOSIS AND TREATMENT
Hideyuki Takeshima, Harumi Yamada and Toshikazu Ushijima
6. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE
Farhadul Islam, Vinod Gopalan and Alfred King-Yin Lam
7. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE
Ahmad R. Safa
8. TARGETING THE HEDGEHOG AND NOTCH SIGNALING PATHWAYS IN CANCER STEM CELLS
Ankita Borah and D. Sakthi Kumar
9. CANCER STEM CELLS IN MULTIPLE MYELOMA AND THE DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES
Franco Dammacco, Patrizia Leone, Franco Silvestris, Vito Racanelli and Angelo Vacca

PART II: ONCOGENOMICS: CIRCULATING BIOMARKERS IN CLINICAL ONCOLOGY
10. BONE METASTASES FROM SOLID TUMORS: IN SEARCH OF PREDICTIVE BIOMARKERS FOR CLINICAL TRANSLATION
Franco Silvestris, Stella D’Oronzo, Domenica Lovero, Raffaele Palmirotta and Franco Dammacco
11. LIQUID BIOPSY AND GENOMIC ASSESSMENT FOR LUNG CANCER: THE ROLE IN CLINICAL PRACTICE?
Véronique Hofman, Simon Heeke, Maryline Allègra, Marius Ilié and Paul Hofman
12. PROGNOSTIC AND PREDICTIVE ROLE OF CIRCULATING TUMOR CELLS
Francesco Schettini, Mario Giuliano and Massimo Cristofanilli
13. CIRCULATING MIRNAS AS TUMOR BIOMARKERS
Vikas Ghai, Inyoul Lee and Kai Wang
14. CIRCULATING DNA IN CANCER DIAGNOSIS AND PROGNOSIS
Eveline E. Vietsch and Anton Wellstein
15. SEQUENCING A SINGLE CIRCULATING TUMOR CELL FOR GENOMIC ASSESSMENT
Lei Xu, Nuria Coll Bastus and Yong-Jie Lu
16. SINGLE NUCLEOTIDE POLYMORPHISMS IN CANCER RESEARCH AND TREATMENT
Massimo Di Maio

PART III: GASTROINTESTINAL TUMORS: MOLECULAR DIAGNOSIS AND TREATMENT
17. GASTRIC CANCERS: A MOLECULAR ROADMAP FOR PATIENT STRATIFICATION AND TARGETED THERAPIES
Maxime Chénard-Poirier and Elizabeth C. Smyth
18. RESISTANCE TO EGFR TARGETING TREATMENTS IN COLORECTAL CANCER
Michela Pucci and Mattia Lauriola
19. CIRCULATING DNA AND PROTEIN BIOMARKERS FOR THE TREATMENT OF TYROSINE KINASE INHIBITORS IN METASTATIC COLORECTAL CANCER
Kjetil Søreide
20. RATIONALE FOR IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANCIES
Vasiliki Michalarea and Elizabeth Smyth
21. PROTEOMICS PROFILING OF PANCREATIC CANCER: ROLES IN BIOMARKER DISCOVERY
Hong Peng, Ru Chen and Sheng Pan
22. EMERGING TECHNOLOGIES FOR THE DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER
Magdalena Swierczewska, Serguei Kozlov and Pavan P. Adiseshaiah
23. PERSONALIZED MEDICINE IN GASTROINTESTINAL STROMAL TUMORS
Margherita Nannini and Guido Biasco
24. CIRCULATING MICRORNAS AS TUMOR BIOMARKERS IN HEPATOCELLULAR CARCINOMA
Albrecht Piiper and Oliverwaidmann

PART IV: PERSPECTIVES IN BREAST CANCER GENOMICS
25. GENE PROFILES IN BREAST CANCER: TRANSLATION TO CLINICAL MEDICINE
Serena Di Cosimo, Maria Grazia Daidone and Vera Cappelletti
26. NOVEL BIOMARKERS PREDICTING THE DEVELOPMENT OF BONE METASTASIS IN EARLY BREAST CANCER
Michele Iuliani, Paolo Manca, Giulia Ribelli, Sonia Simonetti, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini
27. HER2-POSITIVE EARLY BREAST CANCER: AFFORDABLE RISKS, AFFORDABLE THERAPIES, AND NEW DEVELOPMENTS
Pierfranco Conte, Mariavittoria Dieci, Graziavernaci and Valentina Guarneri
28. ROLE OF CIRCULATING TUMOR CELLS IN BREAST CANCER PATIENTS
Rita Lampignano, A.M. Sofie Berghuis, Tanja Fehm and Hans Neubauer
29. OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER: MTOR INHIBITORS AND NEW DRUGS
Paola Ferrari and Andrea Nicolini
30. EXPLORE GENOMIC PROFILES FOR TRIPLE-NEGATIVE BREAST CANCER TO DISCOVER DRUG TARGETS
Xiaosheng Wang
46. BRAF-MUTANT MELANOMA: TREATMENT APPROACHES AND RESISTANCE MECHANISMS
Svenja Meierjohann and Bastian Schilling