Oncogenic Viruses Volume 2

Medical Applications of Viral Oncology Research

1st Edition - September 14, 2022
Editor: Moulay Mustapha Ennaji
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 1 5 6 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 1 6 - 5

Oncogenic Viruses: Medical Applications of Viral Oncology Research, Volume Two builds on the introductory overview of Volume One, Oncogenic Viruses: Fundamentals of Oncogenic… Read more

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Oncogenic Viruses: Medical Applications of Viral Oncology Research, Volume Two builds on the introductory overview of Volume One, Oncogenic Viruses: Fundamentals of Oncogenic Viruses. It looks at recent advances and medical application of research studies on oncoviruses, including examining oncoviruses on a molecular level, covers diagnostic and prognostic viral biomarkers and identifying biomarkers in specific human cancers, and delves into prevention, treatment and the future of cancer therapy of oncoviruses, antiviral activities and vaccination strategies. Advanced topics and the future direction of oncovirology round out the book.

This book is a comprehensive reference for researchers and practitioners engaged in learning more about the role of oncogenic viruses in the pathogenesis of human cancers and how that information can be applied to identify strategies for prevention and treatment.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editor
Preface—Oncogenic Viruses: Up To Recent Knowledge
Acknowledgments
Chapter 1. Vitamin D new therapy for breast cancer prevention
Abstract
1.1 Introduction
1.2 Breast cancer
1.3 Viral etiology of breast cancer
1.4 Mouse mammary tumor virus like
1.5 Human papilloma virus
1.6 Epstein–Barr virus
1.7 Vitamin D
1.8 Food needs and sources
1.9 Storage sites
1.10 Vitamin D receptors
1.11 Vitamin D new therapy for breast cancers prevention
1.12 Mechanism of action
1.13 Vitamin D and breast cancer prevention
1.14 Conclusion
References
Chapter 2. Molecular diagnosis of human papillomavirus related to cervical cancer
Abstract
2.1 Introduction
2.2 Etiopathogenesis of human papillomavirus infection
2.3 Diagnosis of human papillomavirus viral genome
2.4 Conclusion
Acknowledgment
References
Chapter 3. Risk of the development of cancers induced by the consumption of mussels accumulating metallic trace elements
Abstract
3.1 Introduction
3.2 Trace metal elements
3.3 Bivalve molluscs
3.4 Oxidative stress and cancer
3.5 Conclusion
Acknowledgments
References
Chapter 4. Oncolytic virus cancer therapeutic options and integration of artificial intelligence into virus cancer research
Abstract
4.1 Introduction
4.2 History
4.3 General properties of oncovirus
4.4 Oncolytic viral therapy: a new era of treatment
4.5 Applications of oncolytic viral therapy
4.6 Limitations
4.7 Integration of artificial intelligence or machine learning into cancer research
4.8 Future concerns
4.9 Conclusion
Acknowledgment
References
Chapter 5. Oncoviruses: future prospects of molecular mechanisms and therapeutic strategies
Abstract
5.1 Introduction
5.2 Mechanism of oncovirus
5.3 Types and mechanism of oncoviruses
5.4 Genetics of virus
5.5 Types of treatment
5.6 Stem cell transplant therapy
5.7 Future of oncotherapy
5.8 Conclusion
Acknowledgment
References
Chapter 6. Multi-omics methods and tools in dissecting the oncovirus behavior in human host
Abstract
6.1 Introduction
6.2 Types of omics
6.3 Conclusions
References
Chapter 7. Role of viral human oncogenesis: recent developments in molecular approaches
Abstract
7.1 Introduction
7.2 Prevalence of oncovirus
7.3 Classification of oncovirus
7.4 Molecular tools used for oncovirus detection
7.5 Vaccines available for oncovirus
7.6 Statistical analysis of oncovirus
7.7 Oncovirus and cancer progression
7.8 Oncolytic virotherapy
7.9 Conclusion
Acknowledgment
References
Chapter 8. Strategies for the development of hepatitis B virus vaccines
Abstract
8.1 Introduction
8.2 Virus-like particle-based hepatitis B vaccines
8.3 Therapeutic vaccines
8.4 DNA-based vaccines
8.5 mRNA-based vaccines
8.6 Proteins/peptides vaccines
8.7 Cell-based vaccines
8.8 Nanovaccines
8.9 Efficacy of therapeutic vaccines
8.10 Harmlessness
8.11 Immunization coverage
8.12 Conclusion
References
Chapter 9. MYC oncogenes as potential anticancer targets
Abstract
9.1 Introduction
9.2 Biological role of MYC genes
9.3 MYC in normal tissues and cancer
9.4 MYC signal transduction pathway
9.5 Structure of MYC
9.6 The MYC–Max interaction
9.7 MYC as a potential target for antitumor therapy
9.8 Targeting the MYC–Max interaction with small molecule inhibitors
9.9 Indirect targeting of the MYC
9.10 Targeting MYC transcription
9.11 Targeting of MYC expression
9.12 Targeting MYC stability
9.13 Synthetic lethality with MYC
9.14 G-quadruplexes and expression of c-MYC
9.15 Conclusions and perspective
Acknowledgments
References
Chapter 10. Current status of viral biomarkers for oncogenic viruses
Abstract
10.1 Introduction
10.2 Epstein-Barr virus
10.3 Hepatitis B virus and hepatitis C virus
10.4 Human T-cell lymphotropic virus-1
10.5 Human Herpesvirus-8
10.6 Human papillomavirus
10.7 Conclusions
References
Chapter 11. Bioinformatics serving oncoviral studies
Abstract
11.1 Biological database
11.2 Sequence analysis
11.3 Molecular dynamics simulations
11.4 Computer-aided drug discovery
11.5 Systems biology approach
11.6 Artificial intelligence approaches
11.7 Conclusion
References
Chapter 12. QSAR approach for combating cancer cells
Abstract
12.1 Introduction
12.2 Handling and curation of chemical and biological data
12.3 Structures drawing and database building
12.4 Molecular descriptors
12.5 Multivariate analysis
12.6 Multiple linear regression analysis
12.7 Principal component regression
12.8 Partial least squares
12.9 Kernel partial least squares
12.10 Artificial neural network
12.11 Other methods
12.12 Classification-based QSAR approaches
12.13 QSAR model generation
12.14 Model examination and validation
12.15 Internal validation
12.16 External validation
12.17 Applicability domain
12.18 Model application for the prediction of compounds activity
References
Chapter 13. Human papillomaviruses and their carcinogens effect
Abstract
13.1 Introduction
13.2 Epidemiology of human papillomaviruse
13.3 Human papillomaviruse classification
13.4 Human papillomavirus transmission
13.5 Structure, genomic organization, and viral proteins
13.6 Human papillomavirus replication cycle
13.7 Infection evolution
13.8 Molecular mechanisms of HPV-induced carcinogenesis
13.9 Mechanisms of cell transformation
13.10 Conclusion
Acknowledgments
References
Chapter 14. Progress in the development of vaccines against human papillomavirus
Abstract
14.1 Introduction
14.2 Virus-like particle vaccination strategy
14.3 Vaccines prophylactic against human papillomavirus
14.4 Immunization procedures and doses
14.5 Efficacy and safety of human papillomavirus vaccines
14.6 L2-based human papillomavirus prophylactic vaccines
14.7 Human papillomavirus vaccine coverage
14.8 Factors influencing vaccination coverage
14.9 Therapeutic vaccines
14.10 Conclusion
References
Chapter 15. Development and characterization of an electrochemical sensor using molecularly imprinted polymer based on a gold screen-printed electrode for the detection of creatinine and glucose in human urine and saliva
Abstract
15.1 Introduction
15.2 Urine and saliva as noninvasive sources of biomarkers
15.3 Biomarkers in the bloodstream can infiltrate the acini and eventually be secreted into the saliva
15.4 Current electrochemical sensor devices
15.5 Applications of gas sensors in oncology or virology as tools for the detection of biomarkers
15.6 Experimental
15.7 Results and discussion
15.8 Conclusion
Acknowledgments
Declaration of competing interest
References
Chapter 16. Detection of triclosan and sodium lauryl sulfate in environmental samples and cosmetic product by electrochemical sensor based on biomimetic recognition combined with electronic nose
Abstract
16.1 Introduction
16.2 Experimental
16.3 Results and discussion
16.4 Conclusion
Acknowledgments
Declaration of competing interest
Appendix A
References
Index

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Moulay Mustapha Ennaji