Omega-3 Fatty Acids in Brain and Neurological Health

1st Edition

Editors: Ronald Ross Watson Fabien De Meester
Print ISBN: 9780128101742
eBook ISBN: 9780124105478
Imprint: Academic Press
Published Date: 1st June 2014
Page Count: 496
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Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons.

Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health.

Key Features

  • The first book-length collection of original research on the connection between omega-3 fatty acids and the brain
  • Provides a comprehensive introduction to the state of research on omega-3 fatty acids and the brain and directions for future research
  • A foundational collection for neuroscience, neurology, and nutrition research


Neuroscience/neurology research, nutrition research

Table of Contents

  • Preface

    • Fatty Acids and the Brain
    • Omega-3 Fatty Acids in Structural and Functional Neurological Changes
    • Fatty Acids and Neurological Outcomes
    • Contaminants and their Removal from Fish Oils
  • List of Contributors
  • Acknowledgments
  • Chapter 1. Enhanced Longevity and Role of Omega-3 Fatty Acids

    • Introduction
    • Longevity
    • Food Restriction for Enhanced Longevity
    • Calorie Restriction for Longevity
    • Smoking and Reduced Longevity
    • Genetics, a Key Modifier of Longevity
    • Genetic Diseases and Longevity
    • Genomics
    • Environmental Factors and Longevity
    • Animal Tests and Longevity
    • Omega-3 Fatty Acids and Longevity
    • References
    • Further Reading
  • Chapter 2. Molecular Gerontology: Principles and Perspectives for Interventions

    • Introduction
    • Molecular Basis of Aging
    • Genetics, Post-Genetics, and Epigenetics of Aging
    • Aging Interventions
    • Hormetics, Hormesis, and Hormetins
    • References
  • Chapter 3. Peroxisomal Pathways, their Role in Neurodegenerative Disorders and Therapeutic Strategies

    • Peroxisomes
    • Peroxisomal Pathologies
    • Leukodystrophies
    • Therapeutic Strategies
    • Demyelination and Other Leukodystrophies
    • Conclusion
    • References
  • Chapter 4. Unregulated Lipid Peroxidation in Neurological Dysfunction

    • Introduction
    • Lipid Oxidation Biomarkers for Neurological Dysfunction
    • Lipid Peroxidation Products from Linoleic Acid
    • Lipid Peroxidation Products from AA
    • Neurological Dysfunction Associated with Lipid Peroxidation
    • Mechanisms of Free Radical Production in Neurological Disorders
    • References
    • Additional References
  • Chapter 5. Obesity, Western Diet Intake, and Cognitive Impair


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About the Editor

Ronald Ross Watson

Ronald R. Watson, Ph.D., attended the University of Idaho but graduated from Brigham Young University in Provo, Utah, with a degree in chemistry in 1966. He earned his Ph.D. in biochemistry from Michigan State University in 1971. His postdoctoral schooling in nutrition and microbiology was completed at the Harvard School of Public Health, where he gained 2 years of postdoctoral research experience in immunology and nutrition. From 1973 to 1974 Dr. Watson was assistant professor of immunology and performed research at the University of Mississippi Medical Center in Jackson. He was assistant professor of microbiology and immunology at the Indiana University Medical School from 1974 to 1978 and associate professor at Purdue University in the Department of Food and Nutrition from 1978 to 1982. In 1982 Dr. Watson joined the faculty at the University of Arizona Health Sciences Center in the Department of Family and Community Medicine of the School of Medicine. He is currently professor of health promotion sciences in the Mel and Enid Zuckerman Arizona College of Public Health. Dr. Watson is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. Among his patents he has one on a dietary supplement; passion fruit peel extract with more pending. He continues to do research in animals and in clinical trials on dietary supplements and health including studies using omega-3 fatty acids in heart disease prevention and therapy. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 110 books on nutrition, dietary supplements and over-the-counter agents, and drugs of abuse as scientific reference books. He has published more than 500 research and review articles.

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health, and School of Medicine, University of Arizona, Tucson, AZ, USA

Fabien De Meester

Affiliations and Expertise

Managing Director, DMF Ltd Co, Belgium


"This unique encyclopedic work is a great resource for anyone interested in this ubiquitous and fascinating fatty acid. I highly recommend it. Score: 79 - 3 Stars",December 12,2014