Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors

1st Edition - January 15, 2020

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  • Editors: Jesus Giraldo, Francisco Ciruela
  • Hardcover ISBN: 9780128179291
  • eBook ISBN: 9780128179307

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Description

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scientific importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine β-synthase, and Oligomerization of Porphobilinogen Synthase.

Key Features

  • Includes comprehensive coverage of molecular biology
  • Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided
  • Contains contributions from renowned experts in the field of molecular biology

Readership

Scientists working actively in a field, including those at levels ranging from graduate student to senior investigator. New investigators to a field who wish to familiarize themselves with the latest work

Table of Contents

  • 1. Fluorescence microscopy methods for the study of protein oligomerization
    Roberto Arturo Petazzi, Amit Koikkarah Aji and Salvatore Chiantia
    2. Computational prediction and redesign of aberrant protein oligomerization
    Jaime Santos, Valentín Iglesias and Salvador Ventura
    3. Porphobilinogen synthase: An equilibrium of different assemblies in human health
    Eileen K. Jaffe
    4. Prediction and targeting of GPCR oligomer interfaces
    Carlos A.V. Barreto, Salete J. Baptista, António José Preto, Pedro Matos-Filipe, Joana Mourão, Rita Melo and Irina Moreira
    5. Integrated structural modeling and super-resolution imaging resolve GPCR oligomers
    Francesca Fanelli, Aylin C. Hanyaloglu and Kim Jonas
    6. Exploring functional consequences of GPCR oligomerization requires a different lens
    Kyla Bourque, Jace Jones-Tabah, Dominic Devost, Paul B.S. Clarke and Terence E. Hébert
    7. Continuing challenges in targeting oligomeric GPCR-based drugs
    Joaquin Botta, Julia Appelhans and Peter J. McCormick
    8. Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives
    Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura and L. Francesco Agnati
    9. Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action
    Faron-Górecka Agata, Kuśmider Maciej, Solich Joanna, Górecki Andrzej and Dziedzicka-Wasylewska Marta
    10. Oligomerization of G protein-coupled receptors: Still doubted?
    Sergi Ferré, Francisco Ciruela, Vicent Casadó and Leonardo Pardo

Product details

  • No. of pages: 348
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: January 15, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128179291
  • eBook ISBN: 9780128179307

About the Serial Volume Editors

Jesus Giraldo

Dr.Jesús Giraldo currently teaches at Universitat Autònoma de Barcelona in Barcelona, Spain.

Affiliations and Expertise

Universitat Autonoma de Barcelona, Spain

Francisco Ciruela

Dr. Francisco Ciruela currently teaches at University of Barcelona, Barcelona, Spain.

Affiliations and Expertise

University of Barcelona, Spain

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