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Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors - 1st Edition - ISBN: 9780128179291, 9780128179307

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169

1st Edition

Serial Volume Editors: Jesus Giraldo Francisco Ciruela
Hardcover ISBN: 9780128179291
eBook ISBN: 9780128179307
Imprint: Academic Press
Published Date: 15th January 2020
Page Count: 348
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Table of Contents

1. Fluorescence microscopy methods for the study of protein oligomerization
Roberto Arturo Petazzi, Amit Koikkarah Aji and Salvatore Chiantia
2. Computational prediction and redesign of aberrant protein oligomerization
Jaime Santos, Valentín Iglesias and Salvador Ventura
3. Porphobilinogen synthase: An equilibrium of different assemblies in human health
Eileen K. Jaffe
4. Prediction and targeting of GPCR oligomer interfaces
Carlos A.V. Barreto, Salete J. Baptista, António José Preto, Pedro Matos-Filipe, Joana Mourão, Rita Melo and Irina Moreira
5. Integrated structural modeling and super-resolution imaging resolve GPCR oligomers
Francesca Fanelli, Aylin C. Hanyaloglu and Kim Jonas
6. Exploring functional consequences of GPCR oligomerization requires a different lens
Kyla Bourque, Jace Jones-Tabah, Dominic Devost, Paul B.S. Clarke and Terence E. Hébert
7. Continuing challenges in targeting oligomeric GPCR-based drugs
Joaquin Botta, Julia Appelhans and Peter J. McCormick
8. Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives
Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura and L. Francesco Agnati
9. Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action
Faron-Górecka Agata, Kuśmider Maciej, Solich Joanna, Górecki Andrzej and Dziedzicka-Wasylewska Marta
10. Oligomerization of G protein-coupled receptors: Still doubted?
Sergi Ferré, Francisco Ciruela, Vicent Casadó and Leonardo Pardo


Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scientific importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine β-synthase, and Oligomerization of Porphobilinogen Synthase.

Key Features

  • Includes comprehensive coverage of molecular biology
  • Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided
  • Contains contributions from renowned experts in the field of molecular biology


Scientists working actively in a field, including those at levels ranging from graduate student to senior investigator. New investigators to a field who wish to familiarize themselves with the latest work


No. of pages:
© Academic Press 2020
15th January 2020
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Volume Editors

Jesus Giraldo

Dr.Jesús Giraldo currently teaches at Universitat Autònoma de Barcelona in Barcelona, Spain.

Affiliations and Expertise

Universitat Autonoma de Barcelona, Spain

Francisco Ciruela

Dr. Francisco Ciruela currently teaches at University of Barcelona, Barcelona, Spain.

Affiliations and Expertise

University of Barcelona, Spain