In May 1993, a cluster of cases of a lethal disease among healthy young people brought the attention of the world to the southwestern deserts. A previously unknown disease was killing up to 80% of the people it infected. The reaction in the area and across the nation mixed fear, lack of information, and the struggles of doctors to save the victims of an unknown killer with hard science and the age old rhythmns of the desert. What came out was the story of a virus that had been killing since man arrived in the American continents, Hantavirus, with deadly relatives across the Americas and across the world. This book explains why and how the virus kills, and why it is still killing today. Why all of the science aimed at a virus identified back in 1993 has not brought a vaccine or a cure is part of the story, as is how that killer virus fits into the story of "new" diseases across the world. The story of hantavirus disease, what has happened since that first outbreak, and what the real risks are is laid out by an experienced scientist and an award winning journalist living and working in the area of the 1993 outbreak.

Key Features

@introbul:Key Features @bul:* Covers the full story of the recent hantavirus outbreak * Includes interviews with survivors, and local reaction * Presents the science in lay terms * Places the event in the broader context of emerging diseases worldwide * The only account which takes the reader beyond the initial outbreak in 1993-1994, bringing them up to late 1998 * Discusses hantavirus disease in the U.S., Argentina, and Canada


Virologists, infectious disease clinicians and researchers, and other life scientists, as well as interested laypersons; also, those currently living in and researching the Four Corners area.

Table of Contents

The Heart of America/The Middle of Nowhere. An Outbreak of Fear. Unravelling the Mystery. Putting the Puzzle Together. Of Mice and Men. At Last, a Plan. Hantaviruses: Out of Asia. Other Hantaviruses. Three Billion Years. On the Origin of Viruses. Changes, Concealment, and Trojan Horses. Cousins. What We Know. How to Stop a Virus. Outbreaks. Appendix A: Center for Disease Control Guidelines on Prevention of HPS. Appendix B: Sources of Further Information. Appendix C: Abbreviations. Index.


No. of pages:
© 1999
Academic Press
Print ISBN:
Electronic ISBN:

About the authors

David Harper

David R. Harper is currently a Lecturer in Molecular Virology at St. Bartholomew's and the Royal London Medical and Dental School. He has worked with viruses since leaving college in 1981, and has authored three textbooks and one laboratory manual. He has also worked as Research Director for Biocontrol Ltd., and has a wide range of teaching experience.

Affiliations and Expertise

St. Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, U.K.

Andrea Meyer

Affiliations and Expertise

Editor, Cortez Sentinel, Cortez, Colorado U.S.A.


:"...In their clearly written book, Of Mice, Men, and Microbes: Hantavirus, Harper and Meyer examine the history of identification of hantaviruses and describe the pathogenesis of the illnesses they cause and their worldwide influence... Readers will finish the book realizing that no infections are new; it is only our recognition of the causes that is new. Readers will also realize that disease and epidemics follow chance encounters among men, mice and associated microbes. Despite their focus on hantaviruses, the authors take readers on a journey to understand the origin and biology of viruses, the coevolution of viruses and their hosts, and humans' fear of new outbreaks and their eventual conquest with new knowledge... anyone interested in hantaviruses will find that this book tells a very complete story. The host, agent, vector, geography,climate, psychology, and cultural responses of the people who are infected are all described. There is much to learn. @source:--Richard Wenzel, M.D., in NEW ENGLAND JOURNAL OF MEDICINE (March 2000) @qu:"An essential book of those interested in emerging diseases." @source:--P.C. Radich, University of Indianapolis, in CHOICE (2000) @qu:"The authors, one a scientist, the other a journalist, have produced an excellent read for the expert and non-expert alike." @source:--R.C. Spencer in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (1999)