Description

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.

Key Features

  • Highly focused on ocular transporters
  • Most up-to-date research compilation
  • Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Readership

Ophthalmologists and pharmacists

Table of Contents

List of figures and tables

About the authors

Chapter 1: Eye: anatomy, physiology and barriers to drug delivery

Abstract:

1.1 Introduction

1.2 Anatomy and physiology of the eye

1.3 Barriers to ocular drug delivery

1.4 Conclusions

1.5 Acknowledgements

Chapter 2: Biology of ocular transporters: efflux and influx transporters in the eye

Abstract:

2.1 Introduction

2.2 SLC transporters

2.3 ABC transporters

2.4 Conclusions

Chapter 3: Characterization of ocular transporters

Abstract:

3.1 Introduction

3.2 Molecular and cellular characterization

3.3 Functional characterization of transporters

Chapter 4: Transporters and receptors in the anterior segment of the eye

Abstract:

4.1 Introduction

4.2 Transporters and receptors

4.3 Anterior chamber influx transporters

4.4 Anterior chamber efflux transporters

4.5 Anterior chamber receptors

4.6 Other miscellaneous anterior chamber receptors

4.7 Conclusions

Chapter 5: Transporters and receptors in the posterior segment of the eye

Abstract:

5.1 Introduction

5.2 Influx transporters in posterior segment of the eye

5.3 Receptors in posterior segment of the eye

5.4 ABC transporters

5.5 Conclusion

Chapter 6: Transporters in drug discovery and delivery: a new paradigm in ocular drug design

Abstract:

6.1 Introduction

6.2 Transporter-targeted drug delivery to the anterior segment

6.3 Transporter-targeted drug delivery to the posterior segment

6.4 Conclusion

Chapter 7: Transporter-metabolism interplay in the eye

Abstract:

7.1 Introduction

7.2 Metabolizing enzymes in ocular tissues

7.3 Impact of disease state on the expression of metabolizing enzymes

7.4 Efflux transporters

Details

No. of pages:
276
Language:
English
Copyright:
© 2013
Published:
Imprint:
Woodhead Publishing
Print ISBN:
9781907568862
Electronic ISBN:
9781908818317

Reviews

"This is an excellent reference for researchers and scientists interested in ocular drug delivery…It is often a challenge to improve the bioavailability of drugs in various parts of the eye. Successful receptor targeting enhances bioavailability, and this book provides a framework for further research in ocular receptor targeting with the aim of improving bioavailability." Rating: 2 Stars--Doody.com, January 17, 2014