Ocular Periphery and Disorders

Ocular Periphery and Disorders

1st Edition - March 31, 2011

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  • Editors: Darlene A. Dartt, Peter Bex, Patricia D’Amore, Reza Dana, Linda Mcloon, Jerry Niederkorn
  • Paperback ISBN: 9780081016756
  • eBook ISBN: 9780123820839

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This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important diseases, including optic neuritis, thyroid eye disease, and strabismus. The volume offers a basic science background of these topics rather than a strictly clinical focus.

Key Features

  • The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the ocular periphery
  • Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers
  • The best researchers in the field provide their conclusions in the context of the latest experimental results


Students, researchers and practitioners in ophthalmology and optometry, neuroscience, immunology, physiology, cell biology, pharmacology, and related disciplines

Table of Contents

  • I. Anatomy and Pathophysiology of Blinking and Eye Movements
    Eyelid anatomy and the pathophysiology of blinking
    Differentiation and morphogenesis of extraocular muscles
    Extraocular muscle anatomy
    Extracocular muscle metabolism
    Extraocular muscles: proprioception and proprioceptors
    Abnormal eye movements due to disease of the extraocular muscles and their innervation
    Extraocular muscles: functional assessment in the clinic

    II. Structure and Function of the Tear Film, Ocular Adnexa, Cornea, and Conjunctiva in Health and Pathogenesis in Disease
    Meibomian glands and lipid layer
    Lacrimal gland overview
    Lacrimal gland hormone regulation
    Lacrimal gland signaling-neural
    Lids: Anatomy, pathophysiology, and mucocutaneous junction
    Ocular surface-overview of electrolyte and fluid transport across the conjunctiva
    Conjunctival Goblet cells
    Ocular mucins
    Tear drainage
    Cornea overview
    Corneal epithelium-cell biology and basic science
    Corneal nerves-anatomy
    Corneal nerves-function
    Corneal epithelium-wound healing junctions, attachment to stroma receptors, matrix metalloproteinases, intercellular communications
    Corneal epithelium-transport and permeability
    Stem cells of the ocular surface
    The ocular surface-the surgical treatment for corneal epithelial stem cell deficiency, corneal epithelial defects, and periferal corneal ulcer
    Refractive surgery
    Refractive surgery and inlays
    Contact lenses
    Imaging of the cornea
    The corneal stroma
    Corneal dystrophies
    Corneal imaging-clinical
    Corneal scars
    Corneal endothelium-overview
    Regulation of corneal endothelial function
    Regulation of corneal endothelial cell proliferation
    Artificial cornea
    Drug delivery to cornea and conjunctiva-esterase- and protease-directed prodrug design
    Knock-out mice models: cornea, conjunctiva, eyelids, and lacrimal glands
    Gene therapy

    III. Immune Regulation of the Cornea and Conjunctiva and Its Dysregulation in Disease
    Adaptive Immune System and the Eye: Mucosal Immunity
    Adaptive immune system and the eye: T-cell mediated immunity
    Innate immune system and the eye
    Immunoregulatory processes that sustain immune privilege in the eye
    Immunosupressive and anti-inflammatory molecules that maintain immune previlege of the eye
    Antigen-presenting cells in the eye and ocular surface
    Dry eye: An immune-based inflammation
    Penetrating keratoplasty
    Immunopathogenesis of HSV Keratitis
    Immunopathogenesis of Onchocerciasis (River Blindness)
    Immunopathogenesis of pseudomonas keratitis
    Immunobiology of acanthomeba karatitis
    Molecular and cellular mechanisms in allergic conjunctivitis
    Pathogenesis of fungal keratitis
    Conjunctiva Immune surveillance
    Defense mechanisms of tears and ocular surface
    Corneal epithelium- response to infection
    Inflammation of the Conjunctiva
    Concept of Angiogenic Privilege
    Corneal angiogenesis
    Avascularity of the cornea

    IV. Visual Acuity Related to the Cornea and Its Disorders
    Visual optics: pupil
    Contrast sensitivity
    Vera-Diaz- Myopia
    Harb- Hyperopia

Product details

  • No. of pages: 576
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: March 31, 2011
  • Imprint: Academic Press
  • Paperback ISBN: 9780081016756
  • eBook ISBN: 9780123820839

About the Editors

Darlene A. Dartt

Affiliations and Expertise

Senior Scientist, Schepens Eye Research Institute, Harvard Medical School

Peter Bex

Patricia D’Amore

Reza Dana

Reza Dana
In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.

Affiliations and Expertise

Schepens Eye Research Institute, Boston, MA, USA

Linda Mcloon

Jerry Niederkorn

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