Occupational Neurotoxicology

Occupational Neurotoxicology

1st Edition - July 15, 2022

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  • Editors: Michael Aschner, Lucio Costa, Roberto Lucchini
  • Hardcover ISBN: 9780128191767

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Description

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in different ways. Metals and organic compounds, both at high level acute exposure and long-term low-level exposure can affect motor functions, cognition, behavior and neurosensory functions. Sections cover Oil leakage in aircraft, aerotoxic syndrome, Organic solvents, WTC neurotoxicities, Environmental intolerance, Pesticides, Carbon monoxide, Mercury Neurotoxicity in Gold Miners, and the Current evolution of neurobehavioral methods.

Key Features

  • Provides updated information about exposure and neurotoxic outcomes
  • Includes indication on new tools for neurobehavioral assessment
  • Covers practical indications on preventive aspects

Readership

Medical doctors, industrial hygienists, toxicologists, risk assessors, occupational health and safety professionals, who are interested in the identification and prevention of work-related neurotoxicty

Table of Contents

  • Preface
    Roberto G. Lucchini
    1. Oil leakage in aircraft, aerotoxic syndrome
    Gerard Hageman
    2. Organic solvents
    Christoph van Thriel
    3. WTC neurotoxicities
    Roberto G. Lucchini
    4. Environmental intolerance
    Markku Alarik Sainio Sr.
    5. Pesticides
    Diane Schertler Rohlman
    6. Carbon monoxide
    Jonathan Rutchik
    7. Mercury Neurotoxicity in Gold Miners
    Maria Elena Crespo-Lopez
    8. Current evolution of neurobehavioral methods
    Maryse Bouchard

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 15, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128191767

About the Serial Volume Editors

Michael Aschner

Michael Aschner
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and Expertise

Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, NY, USA

Lucio Costa

Lucio Costa
Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.

Affiliations and Expertise

Professor of Toxicology, University of Washington, Seattle, WA, USA

Roberto Lucchini

Roberto Lucchini
Medicine at Mount Sinai, New York. He was also the Director of the World Trade Center Data Center at Mount Sinai and the Director of the NIOSH funded Education and Research Center for the States of New York and New Jersey. In these capacities, he coordinated the epidemiological health surveillance of the workers involved in the clean-up operations after 9/11. Dr. Lucchini was also director of the Selikoff Centers of Occupational Health, the largest center of Occupational Medicine in the USA. Since 2020, Dr Lucchini is a Professor at the School of Public Health, Florida International University, where he continues his research interests with further developments in a highly qualified scientific environment. He has also conducted studies on the risk factors for covid-19 disease severity and mortality, including occupational and environmental exposure to airborne particulates and air pollution. Dr. Lucchini’s research is focused on the health effects of neurotoxic chemicals and the biological mechanisms by which metals, pesticides, persistent organic pollutants, particulate matter and other toxic chemicals can cause injury in the human nervous system, from neurodevelopment to neurodegeneration. He and his team have conducted studies in general populations as well as in occupational groups. With support from Italian National funds, the EU and NIEHS, they have assessed the effects of neurotoxic chemicals across the life span in populations that range in age from early childhood, through adult life to old age. They have also undertaken studies in patients with neurodegenerative diseases and the role of occupational and environmental determinants in aging. These studies are focused in the highly industrialized provinces of Brescia and Taranto and target the exposure to neurotoxic metals including manganese. More recently Dr. Lucchini became involved with the research on the health effect among workers and responders who were exposed to chemicals and intense psychological trauma at the World Trade Center after the 9/11 terroristic attack. He is studying the increased frequency of neurological conditions through the use of fMRI and PET imaging techniques.

Affiliations and Expertise

Florida International University, NY, USA

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