Obesity, Volume 91

1st Edition

Serial Editors: Gerald Litwack
Hardcover ISBN: 9780124077669
eBook ISBN: 9780124115170
Imprint: Academic Press
Published Date: 11th February 2013
Page Count: 512
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Table of Contents

Former Editors



Chapter One. Hormonal Regulation of Lipogenesis

1 Introduction

2 Defining Lipogenesis

3 Lipogenesis in Metabolic Target Tissues

4 Regulation of Lipogenesis

5 Hormonal Regulation

6 Conclusions


Chapter Two. Genetic Determinants of Obesity and Related Vascular Diseases

1 Introduction

2 Genetic Determinants of Obesity

3 Vascular Diseases Related to Overweight and Obesity

4 Conclusions


Chapter Three. Brd2 Gene Disruption Causes “Metabolically Healthy” Obesity: Epigenetic and Chromatin-Based Mechanisms that Uncouple Obesity from Type 2 Diabetes


1 Introduction: The Problem of Obesity and Its Complications

2 Complex Polygenic Interactions with the Environment and Epigenetics in Obesity

3 The “brd2 lo” Mouse Model of “Metabolically Healthy” Obesity

4 Who are “Metabolically Healthy” Obese Humans?

5 Other Animal Models of “Metabolically Healthy” Obesity

6 Derepression of Insulin Transcription in the “brd2 lo” Environment

7 Translational Implications of Epigenetic Reprogramming: Conclusions


Chapter Four. The TBC1D1 Gene: Structure, Function, and Association with Obesity and Related Traits

1 Introduction

2 TBC1D1 Gene Structure and Expression

3 TBC1D1 Protein Structure and Function

4 The TBC1D1 Gene in Obesity and Related Traits

5 Conclusions


Chapter Five. Replication Initiator 1 in Adipose Tissue Function and Human Obesity

1 Introduction

2 Structure of Repin1

3 Cellular Localization of Repin1

4 Repin1 Function in Adipose Tissue

5 Concluding Remarks



First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on obesity.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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About the Serial Editors

Gerald Litwack Serial Editor

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA