Nutritional Management of Renal Disease

3rd Edition

Editors: Joel Kopple Shaul Massry Kamyar Kalantar-Zadeh
Hardcover ISBN: 9780123919342
eBook ISBN: 9780123919359
Imprint: Academic Press
Published Date: 17th December 2012
Page Count: 816
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This translational text offers in-depth reviews of the metabolic and nutritional disorders that are prevalent in patients with renal disease. Chapter topics address the growing epidemic of obesity and metabolic syndrome. Each chapter integrates basic and clinical approaches, from cell biology and genetics to diagnosis, patient management and treatment. Chapters in sections 4-7 include new illustrative case reports, and all chapters emphasize key concepts with chapter-ending summaries. New features also include the latest National Kidney Foundation Clinical Practice Guidelines on Nutrition in Chronic Renal Failure, the most recent scientific discoveries and the latest techniques for assessing nutritional status in renal disease, and literature reviews on patients who receive continuous veno-venous hemofiltration with or without dialysis.

Key Features

  • Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to discuss the underlying research and translation of best practices for the nutritional management and prevention of renal disease
  • Saves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles.
  • Correct diagnosis (and therefore correct treatment) of renal, metabolic, and nutritional disorders depends on a strong understanding of the molecular basis for the disease – both nephrologists and nutritionists will benefit
  • Nephrologists and nutritionists will gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient

  • Case Reports will offer an added resource for fellows, nutritionists, and dieticians who need a refresher course


Practicing nephrologists, nephrology fellows, nutritionists, dieticians, and dialysis nurses; academic and clinical researchers in nephrology and nutrition; and physicians and researchers interested in renal nutrition and related renal diseases (renal cancer, diabetes, glomerulosclerosis, preeclampsia, lupus), such as endocrinologists, geriatricians, bariatric physicians, and diebetologists.

Table of Contents


List of Contributors


Chapter 1. The Influence of Kidney Disease on Protein and Amino Acid Metabolism


CKD Interrupts the Components of Protein Metabolism

Defining Muscle Wasting

Mechanisms of Muscle Wasting

The Ubiquitin-Proteasome System

Synergism of Proteolytic Pathways Causes Muscle Wasting in CKD

Proteolytic Activities Present in Muscles of Patients

Factors Triggering Muscle Wasting in CKD and Other Catabolic States

Myostatin and the Regulation of Muscle Protein Wasting

Myostatin in Muscle Increases in Catabolic Conditions

Beneficial Responses from Blocking Myostatin in Models of Muscle Catabolism

Blocking Myostatin can Suppress CKD-Induced Muscle Wasting

CKD Changes the Concentrations of Certain Amino Acids

Links Between Amino Acid and Protein Metabolism



Chapter 2. Carbohydrate Metabolism in Kidney Disease and Kidney Failure


Insulin Resistance

Insulin Secretion

Insulin Clearance


Carbohydrate Metabolism in Patients with Renal Replacement Therapy

Treatment of Diabetes Mellitus in Diabetics with CKD

Drug Management in Diabetics with CKD (Figure 2.1)


Chapter 3. Altered Lipid Metabolism and Serum Lipids in Kidney Disease and Kidney Failure


Plasma Lipid and Lipoprotein Profile in CKD/ESRD Patients

The Nature and Mechanisms of CKD-Induced Lipid Abnormalities

The Nature and Mechanisms of Adverse Effects of Lipid Disorders in CKD

Treatment of CKD-Associated Dyslipidemia

Potential Adverse Effects of Statins


Chapter 4. Uremic Toxicity


Uremic Symptoms and Signs

Toxic Effects of Uremic Plasma or Serum

Definition of a


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© Academic Press 2013
Academic Press
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About the Editor

Joel Kopple

Shaul Massry

Kamyar Kalantar-Zadeh


"This is a useful tool for nephrologists, especially in the clinical setting. The easy readability and suggested applications will also attract medical students, internists, renal dietitians, nurse practitioners, and physician assistants…Nutrition with its emerging importance at the cellular level is sometimes overlooked in training medical students. This book provides ready access to both the science and clinical application needed to treat the CKD population." Rating: 3, February 28, 2014
"The Third Edition of this classic translational text offers in-depth reviews of the metabolic and nutritional disorders prevalent in patients with renal disease.", April 24, 2013
"This edition reflects changes in the field, such as the increased evidence on the importance of inflammatory, oxidative, and carbonyl stress, and the greater prevalence and severity of obesity and its clinical consequences; therapeutic strategies for obesity treatment in regard to chronic kidney disease prevention and treatment; the nutritional management of people receiving chronic renal replacement therapy; and methods for slowing the progression of chronic renal disease..."--Reference and Research Book News, February 2013