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SECTION I Introduction
1. Introduction to nutritional epigenomics
SECTION II Epigenetic regulators
2. DNA methylation and chromatin modifications
3. Small non-coding RNAs as epigenetic regulators
SECTION III Epigenomic regulation of disease
4. The impact of race and ethnicity in the social epigenomic regulation of disease
5. The epigenomic impact of methylation in metabolic dysfunction and cancer
6. The role for DNA/RNA methylation on neurocognitive dysfunctions
7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease
8. Cancer and non-coding RNAs
9. Race in the social-epigenomic regulation of pre- and perinatal development
10. Maternal nutrition, epigenetic programming and metabolic syndrome
11. Epigenetic inheritance of metabolic signals
12. The paternal diet regulates the offspring epigenome and health
SECTION V Nutritional epigenomics and the circadian clock
13. The interplay between diet, epigenetics and the circadian clock
14. Epigenetic regulation of the fetal circadian clock: implications for nutritional programming of circadian and metabolic function
15. The role for the microbiome in the regulation of the circadian clock and metabolism
SECTION VI Carloric restriction and exercise in the epigenomic regulation of aging and disease
16. Epigenomic reprogramming of caloric restriction on aging
17. Dietary restriction in the epigenomic regulation of cardiovascular diseases
18. Epigenomic adaptations of exercise in the control of metabolic disease and cancer
SECTION VII Macro- and micronutrients as epigenomic regulators of health and disease
19. B-vitamins and one-carbon metabolism: impacts on the epigenome during development
20. Food bioactives in the epigenomic regulation of metabolic disease
21. Stilbenoids as dietary regulators of the cancer epigenome
22. Regulation of non-coding RNAs by phytochemicals for cancer therapy
23. Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease
SECTION VIII Diet, epigenetics and the microbiome
24. Diet-microbiome interactions and the regulation of the epigenome
25. Gut dysbiosis and its epigenomic impact on disease
26. Microbiota, the brain and epigenetics
Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders.
Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.
- Empowers the reader to employ nutritional epigenomics approaches in their own research
- Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease
- Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies
Academic and industry researchers in the fields of nutrition, kinesiology, public health, psychology, medicine, pharmacy, human genetics, genomics, biology, molecular biology, biochemistry, and cardiology; advanced undergraduate students, graduate students, postgraduates
- No. of pages:
- © Academic Press 2019
- 23rd July 2019
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Dr. Bradley Ferguson is Assistant Professor of Nutrition at the University of Nevada, Reno, NV. His lab adopts integrative, translational research approaches that encompass bioinformatics, in vitro cell culture, and in vivo animal models to elucidate dietary food components that act as epigenetic modifiers, as well as the role of dietary epigenetic modifiers on pathological cardiac signaling, gene expression, and remodeling. He also seeks to understand how acetylation and deacetylation links metabolic disease (obesity and diabetes) to pathological cardiac remodeling and dysfunction. Dr. Ferguson has published his findings across a wide range of peer reviewed journals, including Scientific Reports, Journal of Animal Science, Current Pharmaceutical Design, and the Journal of Molecular and Cellular Cardiology.
Assistant Professor of Nutrition, University of Nevada, Reno, NV, USA
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