Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health

Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health

1st Edition - December 1, 2021

Write a review

  • Editors: Debasis Bagchi, Sunny Ohia
  • eBook ISBN: 9780128232194
  • Paperback ISBN: 9780128212325

Purchase options

Purchase options
DRM-free (EPub, PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health explores the role of appropriate nutrition and digestive enzymes in healthy digestion. The book addresses salient gastrointestinal features involved in healthy digestion pathophysiology, including coverage of the enzyme-microbiome connection and linkage, features of indigestion problems, roles of traditional and conventional ethnic foods, structurally diverse digestive enzymes, drugs, nutraceuticals and novel digestive formulations. In addition, the book addresses technological breakthroughs that have led to recent, novel discoveries and outlines nutritional guidelines and recommendations to achieve healthy digestion. This book is a useful resource for nutrition researchers, nutritionists, physicians working in the field of digestive health, pharmacists, food experts, health professionals, nurses and general practitioners, public health officials and those teaching or studying related fields.

Key Features

  • Provides coverage of digestion, human physiology and the enzyme-microbiome linkage
  • Covers indigestion problems, including gut dysbiosis and its role in chronic disease
  • Addresses traditional and conventional ethic foods
  • Discusses digestive enzymes, as well as digestive drugs, enzymes, nutraceuticals and novel formulations


Nutrition researchers, nutritionists, physicians working in the field of digestive health, pharmacists, food experts, health professionals, nurses and general practitioners, and public health officials as well as those teaching or studying related fields

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • Preface
  • A. Introduction
  • Chapter 1. Chemistry and mechanism of the diseases caused by digestive disorders
  • Introduction
  • Methods
  • Chemistry behind human digestive system and digestive disorders
  • Conclusion
  • Chapter 2. Current trend in the pharmacotherapy of digestive disorders
  • Introduction
  • Pharmacotherapy of peptic ulcer diseases
  • Pharmacotherapy of gastroeosphageal reflux
  • Pharmacotherapy of constipation and diarrhea
  • Pharmacotherapy of irritable bowel syndrome
  • Pharmacotherapy of hemorrhoids
  • Pharmacotherapy of disorders of the pancreas
  • Pharmacotherapy of inflammatory bowel disease
  • Conclusions
  • Chapter 3. Food derived ACE inhibitory peptides: science to application
  • Introduction
  • Production of bioactive peptides
  • Peptide transport systems
  • ACE inhibitory behavior of milk fermented by Lactobacillus
  • Functionality of bioactive peptides
  • Applications of ACE inhibitory peptides for the management of health problems
  • Limitations and challenges
  • Future perspectives
  • Chapter 4. Age- and obesity-related metabolic changes and their impact on the incidence of digestion, metabolism, and immune health
  • Introduction
  • Impaired digestion and metabolism
  • Osteoporosis and its links with obesity
  • The obesity paradox and osteoporosis
  • The link between diabetes and osteoporosis
  • Conclusions
  • B. Digestion, human physiology and enzyme-microbiome linkage
  • Chapter 5. Digestion and immune health
  • Introduction
  • The immune system and digestive tract
  • Impairment of digestion
  • Dietary habit
  • Interaction of digestive and immune systems
  • Digestion and immune health in normal well beings and diseases
  • Conclusion
  • Chapter 6. Influence of diet on gastrointestinal immunology
  • Introduction
  • Immune cells at the gastrointestinal border
  • Influence of gut microbiota on immune system of gastrointestinal tract
  • Role of diet in immune homeostasis of the gut
  • Diet related dysbiosis and inflammatory diseases
  • Immunonutrition in the treatment of dysbiosis-related diseases
  • Concluding remarks
  • Chapter 7. Immune dysregulation in nonalcoholic steatohepatitis
  • Introduction to the spectrum of NAFLD
  • Molecular pathology of NASH
  • Liver damage and immune activation
  • Extrahepatic factors triggering inflammation in NASH
  • Innate immunity and NASH
  • Adaptive immunity and NASH
  • Therapeutic interventions to control inflammation in NASH
  • Conclusion
  • Chapter 8. Digestion and inflammatory responses
  • Introduction
  • Digestive system
  • Physiology of digestion
  • Pathological condition
  • Impact of inflammation in pathological condition
  • Implication of inflammation in digestion
  • Conclusion
  • Chapter 9. Digestion and gut microbiome
  • Introduction
  • Digestion
  • Digestive enzymes
  • The enzyme–microbiome linkage
  • Metabolic diseases related to digestive enzyme defects
  • How defective digestive enzymes/altered gut microbiome affects immune health
  • Digestive enzymes as supplements to boost immune health/gut microbiota
  • Conclusion
  • Chapter 10. Hyperlipidemia in cardiovascular health and digestion
  • Introduction
  • Lipases
  • Inhibition of lipase activity—control of infection and management of obesity
  • Chapter 11. Role of food structure in digestion and health
  • Introduction
  • Association of food structure to sensory reception
  • Association of food structure to digestion and health
  • General food digestion process
  • Properties of food influencing digestion process
  • Release of nutrients and Its bioavailability during digestion
  • Role of food structure in lipid digestion
  • Interaction of starch in food material and digestion
  • Behavior of protein in food matrix
  • Role of food structure on bioavailability of microcomponents
  • Modulation of food structure to improve digestion and health promoting behavior of food
  • Conclusion
  • Chapter 12. High-fat diet and constipation
  • Introduction
  • High-fat diet is a risk for functional constipation in children
  • High dietary saturated fat intake and constipation
  • HFD-induced constipation in mice
  • Role of mucus in the pathogenesis of constipation
  • Role of microbiota in HFD-induced constipation
  • Conclusion
  • Chapter 13. Effect of functional food ingredients on nutrient absorption and digestion
  • Introduction
  • Dietary fiber
  • Phytosterols
  • Polyphenolic compounds
  • Glucosinolates
  • Phytic acid
  • Medium-chain triglycerides
  • Soy proteins
  • C. Indigestion problems
  • Chapter 14. Impact of helicobacter pylori on human physiology and digestive disorders
  • Introduction
  • Epidemiology
  • Effect of H. pylori on human physiology
  • Effect of H. pylori on digestive disorders
  • Conclusions
  • D. Traditional and conventional ethnic foods
  • Chapter 15. Role of turmeric and cinnamon spices in digestive, metabolic, and immune systems
  • Introduction
  • Turmeric: a brief overview
  • Benefits of turmeric for stomach problems/digestive disorder
  • Effects of turmeric on the metabolism
  • Turmeric as immune booster
  • Cinnamon: an overview
  • Major chemical constituents
  • Effect of cinnamon on digestive system and metabolic disorder
  • Immunomodulatory effect of cinnamon
  • Summary
  • Chapter 16. Ayurvedic digestion recipes—Jal Jeera and Churan
  • Introduction
  • Healthy and refreshing Jal jeera
  • Jal jeera churan (dry powder) and other popular forms
  • Other popular digestive nutraceuticals containing Jal jeera components
  • Pharmacological profile of common ingredients of Jal jeera
  • Experimental evidences on modulation of digestion and metabolism by the common ingredients of jal jeera
  • Conclusion
  • Chapter 17. Kimchi and other fermented foods for gastrointestinal health
  • Introduction
  • Lactic acid bacteria and their functional properties in Korean fermented food
  • Health benefits of Kimchi, Doenjang, and Cheonggukjang
  • Korean fermented food for gastrointestinal health
  • Conclusion
  • Method statement
  • Chapter 18. Pyroglutamyl peptides in Japanese fermented foods and protein hydrolysate enhance production of host-antimicrobial peptides and ameliorate microbial imbalance
  • Introduction
  • Traditional Japanese seasonings
  • Generation of pyroglutamyl peptides
  • Effects of pyroglutamyl peptides on gut microbiota and colitis
  • Mechanism of effect of pyroGlu-Leu on gut microbiota
  • Impact of Japanese foods and protein hydrolysate on gut microbiota
  • Chapter 19. Jackfruit and its beneficial effects in boosting digestion and immune-enhancing properties
  • Introduction
  • Jackfruit (Artocarpus heterophyllus Lam)
  • Nutrition value and chemical composition
  • Carbohydrates
  • Proteins
  • Lipids
  • Secondary metabolites
  • Minerals and vitamins
  • Therapeutic values of jackfruit
  • Dietary fibers of jackfruit/seeds helps in digestion
  • Jackfruit extract inhibits hemoglobin glycation and protects internal organs
  • Low glycemic index by jackfruit could be due to the presence of antioxidants such as vitamin C, β-carotene, and lycopene
  • Immunomodulatory effect of jackfruit could be due to the presence of lectins
  • Jacalin
  • Artin M (KM+/artocarpin)
  • Immunomodulatory role of Jacalin and Artin M
  • Conclusion
  • Chapter 20. Combatting chronic metabolic disorders and delaying aging by improving glucose-insulin metabolism and fat accumulation in nondiabetics: emphasizing dietary links
  • Introduction
  • Historical perspective
  • More evidence that surplus dietary refined carbohydrates, fats, and calories cause serious metabolic perturbations
  • Detailing dietary constituents
  • IR and FM accumulation during continuum of risks period
  • Paradox of aging
  • Therapeutic interventions to maintain an optimal-working glucose–insulin system over a lifespan
  • E. Digestive enzymes
  • Chapter 21. Efficacy of N-SORB, a proprietary KD120 MEC metabolically activated enzyme formulation in digestion: a randomized, double-blind, placebo-controlled investigation and case studies
  • Introduction
  • Materials and methods
  • Results
  • Discussion
  • Conflict of interests and funding
  • F. Digestive drugs, nutraceuticals and novel formulations
  • Chapter 22. Fat-soluble vitamins: the key role players in immunomodulation and digestion
  • Introduction
  • An overview on immunity
  • Common sources and biochemical characteristics of fat-soluble vitamins
  • Various effects on immunomodulatory functions
  • Concluding remarks
  • Chapter 23. Health benefits of inulin-type fructan on gut microbiome, digestive health, immunity, and nutrition
  • Introduction
  • Inulin-type fructan
  • Fermentation of inulin-type fructan by intestinal bacteria
  • Nutritional function of inulin-type fructan
  • Summary
  • Chapter 24. Gut health benefits of licorice and its flavonoids as dietary supplements
  • Significance of licorice for gut health in traditional systems of medicine
  • Key chemical constituents of licorice
  • Use of licorice in dietary supplements
  • Preclinical data on gut health benefits of licorice: biological activities of licorice flavonoids
  • Licorice as a prebiotic for the homeostasis of gastrointestinal microbiota
  • Benefits of combining probiotics with licorice
  • Products containing licorice with probiotics in the market for gut health (Fig. 24.5)
  • Clinical summary of licorice containing supplements for gut health
  • Regulatory and safety considerations
  • Conclusion
  • Chapter 25. Prebiotics and probiotics in prevention of food allergy
  • Introduction
  • Fetal immunity responses to prebiotics and probiotics
  • Probiotics
  • Prebiotics
  • Food allergy
  • Gut microbiome and food allergy relation
  • Prevention of food allergy by probiotics
  • Role of prebiotics in preventing food allergy
  • Conclusion
  • Chapter 26. Nutraceutical and phytopharmaceuticals in immune health
  • Introduction
  • Food plants as a source for nutraceuticals
  • Immunomodulatory potential of phytochemicals
  • Digestion and bioavailability of bioactive phytochemicals derived from Curcuma longa, Moringa oleifera, and Punica granatum
  • Retention of immunomodulatory effects by metabolites following passage through the gastrointestinal tract
  • Conclusion
  • Chapter 27. Nutraceuticals in digestive therapy
  • Introduction
  • Lifestyle, environment, and type of diet
  • Human genetic variation
  • Summary
  • Summary
  • Conclusion
  • Chapter 28. Role of probiotics and prebiotics in digestion, metabolism, and immunity
  • Introduction
  • Probiotics and prebiotics in digestion
  • Probiotics and prebiotics in metabolism
  • Probiotics and prebiotics in immunity
  • Safety of probiotics and prebiotics
  • Conclusion
  • Chapter 29. Edible insects and gut health
  • Introduction
  • Insect components for gut health
  • Effect of insect components on human gut health
  • Effect of insect components on human health and immunity
  • Consumer behavior and acceptance of edible insects as food
  • Potential risks of entomophagy
  • Future prospective
  • Commentary: A treatise on digestive health
  • Index

Product details

  • No. of pages: 586
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: December 1, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128232194
  • Paperback ISBN: 9780128212325

About the Editors

Debasis Bagchi

Debasis Bagchi
Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Affiliations and Expertise

Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USA

Sunny Ohia

Sunny Ohia, Ph.D., FARVO, FAS is a Professor of Pharmacology in the College of Pharmacy and Health Sciences at Texas Southern University. Dr. Ohia has over 28 years of experience in higher education having served as a member of faculty in five universities in Canada and the United States (U.S.). He holds other academic appointments as adjunct professor of ophthalmology and visual sciences at the University of Nebraska Medical Center, Omaha and as an adjunct professor of integrative biology and pharmacology at the University of Texas Health Sciences Center in Houston. Dr. Ohia is a Fellow of the Nigerian Academy of Science and a Fellow of the Association for Research in Vision and Ophthalmology. He is the author of more than 250 original papers, book chapters, books, and abstracts and, holds three U.S. and five international Patents for his scientific work. Dr. Ohia received his Ph.D. in pharmacology from the University of Glasgow, in Scotland, United Kingdom. Dr. Ohia completed postdoctoral research training fellowships in neuroscience and in ophthalmology/visual sciences at Memorial University of Newfoundland, Canada and the University of Louisville, School of Medicine, KY, respectively.

Affiliations and Expertise

Professor, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA

Ratings and Reviews

Write a review

There are currently no reviews for "Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health"