Description

The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated.
Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides.
At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide.
An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.

Table of Contents

Preface. List of Contributors. I. Signalling via nucleotides in the nervous system. 1. Current status of purinergic signalling in the nervous system (G. Burnstock). 2. Modulation of purinergic neurotransmission (P. Sneddon, T.D. Westfall, L.D. Todorov, S. Mihaylova-Todorova, D.P. Westfall, C. Kennedy). II. Molecular biology of P2Y receptors. 3. Molecular biology of P2Y receptors expressed in the nervous system (T.E. Webb, E.A. Barnard,). 4. P2Y receptors in the nervous system: molecular studies of a P2Y2 receptor subtype from NG108-15 neuroblastoma x glioma hybrid cells (G.A. Weisman, R.C. Garrad, L.J. Erb, C. Santos-Berrios, F.A. Gonzalez). 5. Nucleotide radiolabels as tools for studying P2Y receptors in membranes from brain and lung tissue (G. Reiser, W. Laubinger, R. Schäfer). III. Molecular biology of P2X receptors. 6. Evolving view of quarternary structures of ligand-gated ion channels (A. Nicke, J. Rettinger, C. Büttner, A. Eichele, G. Lambrecht, G. Schmalzing). 7. Cloning, functional characterization and developmental expression of a P2X receptor from chick embryo (A. Ruppelt, B.T. Liang, F. Soto). IV. Development of nucleotide analogues. 8. Developments in P2 receptor targeted therapeutics (M. Williams). 9. Novel ligands for P2 receptor subtypes in innervated tissues (G. Lambrecht, S. Damer, B. Niebel, S. Czeche, P. Nickel, J. Rettinger, G. Schmalzing, E. Mutschler). 10. Molecular recognition in P2 receptors: ligand development aided by molecular modeling mutagenesis (K.A. Jacobson, C. Hoffmann, Y.-C. Kim, E. Camaioni, E. Nandanan, S.Y. Yang, D.-P. Guo, X.-D. Ji, I. Von Kügelgen, S. Moro, A.U. Ziganshin, A. Rychkov, B.F. King, S.G. Brown, S.S. Wildeman, G. Burnstock, J.L. Boyer, A. Mohanram, T.K. Harden). V. Release of nucleotides. 11. Release of ATP and UTP from astrocytoma cells (T. K. Harden, E.R. Lazarowski). 12. Quantal A

Details

No. of pages:
429
Language:
English
Copyright:
© 1999
Published:
Imprint:
Elsevier Science
Print ISBN:
9780444500823
Electronic ISBN:
9780080862453

About the editors

P. Illes

Affiliations and Expertise

Institut fur Pharmakologie und Toxicologie, University of Leipzig, Hartelstrasse 16-18, Leipzig 04017, Germany

H. Zimmermann

Affiliations and Expertise

Biozentrum der J.W. Goethe - Universitat, Zoologiches Institut, University of Frankfurt, AK Neurochemie, Marie-Curie-Str. 9, D-60439 Frankfurt am Main, Germany

Reviews

@from:(R.A. North, University of Sheffield) @qu:(...)Expectations are rather low for yet another volume on nucleotides: this one is based on a meeting in the summer of 1998 held in Leipzig. Yet, even hackneyed reviewers will have to concede that this volume does try hard to break the mould. In fact, it contains some real gems.(...)If you are in the field, you will want the book; the elation comes in the few outstanding chapters. If you are outside the field, you will certainly find these accounts authoritative and stimulating(...) @source:Trends in Neurosciences