Nucleotide Metabolism

Nucleotide Metabolism

An Introduction

1st Edition - January 1, 1973

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  • Authors: J. Frank Henderson, A. R. P. Paterson
  • eBook ISBN: 9781483261157

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Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.

Table of Contents

  • Contents


    Nomenclature and Abbreviations

    Part I. General Aspects of Nucleotide Metabolism

    Chapter 1. Nucleotides as Tissue Constituents

    I. Introduction

    II. Historical Development

    III. Free Nucleotides of Cells and Tissues


    Chapter 2. Configuration and Conformation of Nucleosides and Nucleotides

    I. Introduction

    II. The Sugar

    III. The Bases

    IV. Base-Sugar Relationships


    Chapter 3. Functions of Nucleotides

    I. Introduction

    II. Role of Nucleotides in Energy Metabolism

    III. Transformation of Nucleotide Coenzymes

    IV. Group-Transfer Reactions of Nucleotide Coenzymes

    V. Nucleotides as Structural Units

    VI. Physiological Functions of Nucleotides

    VII. Regulatory Functions of Nucleotides


    Chapter 4. The Three Levels of Phosphorylation

    I. Transphosphorylation Mechanisms

    II. Nucleoside Monophosphate Kinases

    III. Nucleoside Diphosphate Kinases

    IV. Kinases and the Generation of High-Energy Phosphoryl Groups


    Chapter 5. Carbon and Nitrogen Transfer Reactions in Nucleotide Metabolism

    I. Folic Acid Coenzyme Reactions

    II. Glutamine Amide Transfer Reactions

    III. Aspartate Amino Transfer Reactions and Amide Syntheses

    IV. Phosphoribosyl Transfer Reactions


    Chapter 6. Ribose Phosphate Synthesis

    I. Introduction

    II. Direct Phosphorylation of Pentoses

    III. The Pentose Phosphate Pathway

    IV. Ribose 1-Phosphate Synthesis

    V. The Formation of Phosphoribosyl Pyrophosphate


    Part II. Purine Ribonucleotide Metabolism

    Chapter 7. Purine Biosynthesis de Novo

    I. Introduction and Early History

    II. The Reactions of Purine Biosynthesis de Novo

    III. Summary of the Pathway

    IV. Control of Purine Biosynthesis de Novo

    V. Physiological Significance

    VI. Summary


    Chapter 8. Purine Ribonucleotide Synthesis from Purine Bases and Ribonucleosides

    I. Introduction and Early History

    II. Purine Phosphoribosyltransferases

    III. Purine Ribonucleoside Kinases

    IV. Anabolic Role of Purine Ribonucleoside Phosphorylase

    V. Phosphate Transfer Pathway

    VI. Regulation of Purine Nucleotide Synthesis

    VII. Summary


    Chapter 9. Interconversion of Purine Ribonucleotides

    I. Introduction and Early History

    II. Adenylate and Guanylate Synthesis from Inosinate

    III. Inosinate Synthesis from Guanylate and Adenylate

    IV. Individual Enzymes

    V. Function and Operation

    VI. Regulation

    VII. Effects of Drugs

    VIII. Summary


    Chapter 10. Catabolism of Purine Nucleotides

    I. Introduction

    II. Catabolic Enzymes of Uric Acid Synthesis

    III. Breakdown of Uric Acid

    IV. Comparative Aspects of Purine Catabolism

    V. Urinary Purines Other than Uric Acid

    VI. Summary


    Part III. Pyrimidine Ribonucleotide Metabolism

    Chapter 11. The de Novo Pathway of Pyrimidine Nucleotide Biosynthesis

    I. Introduction: Historical Development and Precursors of the Pyrimidine Ring Atoms

    II. The Orotate Pathway of Uridylate Synthesis

    III. Origin of the Cytidine Phosphates

    IV. Regulation of the Orotate Pathway

    V. Summary


    Chapter 12. Pyrimidine Ribonucleotide Synthesis from Bases and Ribonucleosides

    I. Introduction

    II. Metabolism of Pyrimidine Bases and Their Ribonucleosides

    III. Summary


    Chapter 13. Catabolism of Pyrimidine Bases

    I. Introduction

    II. The Reductive Pathway

    III. Urinary Pyrimidines

    IV. The Oxidative Pathway


    Part IV. Purine and Pyrimidine Deoxyribonucleotide Metabolism

    Chapter 14. Deoxyribonucleoside Metabolism

    I. Introduction

    II. Deoxyribonucleoside Deamination

    III. Deoxyribonucleoside Phosphorolysis

    IV. Sources of Deoxyribose

    V. Deoxyribonucleoside Kinases

    VI. Summary


    Chapter 15. Interconversion of Deoxyribonucleotides

    I. Thymidylate Synthesis

    II. Formation of Deoxyuridylate

    III. Deoxyribonucleotide Kinases

    IV. Summary


    Chapter 16. Enzymatic Reduction of Ribonucleotides

    I. Introduction

    II. Ribonucleotide Reduction in Escherichia coli

    III. Ribonucleotide Reduction in Other Cells

    IV. Summary


    Appendix. Metabolism and Biochemical Effects of Purine and Pyrimidine Antimetabolites

    Author Index

    Subject Index

Product details

  • No. of pages: 322
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483261157

About the Authors

J. Frank Henderson

A. R. P. Paterson

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