Nucleic Acid Sensing and Immunity, Part A

Nucleic Acid Sensing and Immunity, Part A

1st Edition - February 22, 2019

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  • Editor: Claire Vanpouille-Box
  • eBook ISBN: 9780128159804
  • Hardcover ISBN: 9780128159798

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Description

Nucleic Acid Sensing and Immunity - PART A, Volume 344, provides a comprehensive overview of the nucleic acid machinery, from plants to mammalians, as well as their regulation. Specific chapters in this updated release include Molecular bases of discrimination between self from non-self nucleic acids, Intracellular RNA sensing in mammalian cells, Nuclear DNA damage and nucleic acid sensing, Negative regulation of nucleic acid sensing, Dendritic cell responses to exogenous nucleic acids, Activating the nucleic acid-sensing machinery for anticancer immunity, and Nucleic acid sensing and inflammasomes, amongst other topics.

Key Features

  • Provides an accurate, state-of-the-art resource on RNA sensing
  • Includes the work of a well-known tumor immunologist
  • Links intestinal host defense and viral nucleic acid sensing
  • Presents a chapter on the negative regulation of DNA sensing, a timely topic

Readership

Immunologists to tumor immunologists and DNA damage biologists

Table of Contents

  • Preface
    Claire Vanpouille-Box
    1. Molecular bases of discrimination between self from non-self nucleic acids
    Taro Kawai
    2. Intracellular RNA sensing in mammalian cells
    Nikolai Khodarev
    3. Nuclear DNA damage and nucleic acid sensing
    Fabrizio Ensoli
    4. Negative regulation of nucleic acid sensing
    Sagi Shapira
    5. Dendritic cells responses to exogenous nucleic acids
    Stefania Gallucci
    6. Activating the nucleic acid-sensing machinery for anticancer immunity
    Michael Gough
    7. Nucleic acid sensing and inflammasomes
    Paras Anand

Product details

  • No. of pages: 269
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: February 22, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128159804
  • Hardcover ISBN: 9780128159798

About the Serial Volume Editor

Claire Vanpouille-Box

Claire Vanpouille-Box
Claire Vanpouille-Box received her Ph.D. in Experimental Pharmacology in 2011 from the University of Angers, France. Determined to pursue an academic career and intrigued by the emerging role of radiation in cancer immunotherapy, she decided to join the lab of Dr. Demaria in 2011 to conduct her postdoctoral training. Claire is currently holding a junior faculty position as an instructor in radiation oncology at Weill Cornell Medicine where she is focusing her research to study the mechanisms whereby radiation therapy can convert a tumor into an in situ individualized vaccine. In particular, Claire is leveraging her multidisciplinary background to better understand how radiation should be administered to induce anti-tumor immunity. She has published 28 articles in peer-reviewed scientific journals and have received many prestigious awards among which the 2014-Marie Curie Award from the Radiation Research Society (RRS), the 2015-AACR Susan G Komen Scholar-in-training award from the American Association for Cancer Research (AACR) and the 2017-AAI Early Career Faculty travel grant from the American Association of Immunologists (AAI).

Affiliations and Expertise

Weill Cornell Medicine Radiation Oncology

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