Nucleic Acid Nanotheranostics - 1st Edition - ISBN: 9780128144701

Nucleic Acid Nanotheranostics

1st Edition

Biomedical Applications

Editors: Marco Filice Jesus Ruiz-Cabello
Paperback ISBN: 9780128144701
Imprint: Elsevier
Published Date: 1st January 2019
Page Count: 375
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Table of Contents

1. Introduction to Nanotheranostics for biomedical applications of nucleic acids

Part 1 Biomedical Applications of Nucleic Acids
2. Therapeutic nucleic acids- a state of the art
3. Application of Nucleic Acids in Cancer Therapy
4. Cardiovascular application of Nucleic Acids
5. Application of Nucleic Acids in Respiratory disease

Part 2 Diagnosis applications of Nucleic Acids
6. Circulating nucleic acids as biomarkers
7. Recent advances in the development of nucleic acid diagnostics

Part 3 Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery
8. Viral gene therapy
9. Non viral gene therapy: Peptiplexes
10. Non viral gene therapy:Lipoplexes
11. Non viral gene therapy: Polyplexes
12. Non viral gene therapy:Nanoplexes
13. Non viral gene therapy: Nucleic acid nanostructures

Part 4 Considerations of nanomedicine
14. Toxicological Aspects for Nanomaterial in Humans
15. Imaging of nucleic acid delivery
16. The state of investigational and approved nanomedicine products for nucleic acid delivery
17. Conclusion/Outlook


Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.

Key Features

  • Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas
  • Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging
  • Presents the only book to include an analysis of nanoformulations approved for clinical use


Materials Scientists and Biochemists, Biomedical engineers, Clinicians, Pharmaceutical chemists, and researchers working on nanomaterials, especially those with healthcare applications


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© Elsevier 2019
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Ratings and Reviews

About the Editors

Marco Filice Editor

Marco Filice graduated in Pharmaceutical Chemistry and Technology and obtained a PhD in Pharmaceutical Chemistry from the University of Pavia, Italy. Dr. Filice is currently a member of the Advanced Imaging Unit of CNIC, Madrid, Spain. Dr Filice has published 53 peer-reviewed publications (25 in top 25%) in high impact factor ISI journals. He was invited as Guest Editor for a Thematic Issue in Current Organic Chemistry. His research interests and expertise is in oriented immobilization of biomacromolecules for the preparation of nanobiohybrid devices useful in diagnosis and therapy (theragnosis) of cardiovascular diseases; characterization of magnetic nanoparticles; surfaces and colloids functionalization; and multimodality molecular imaging.

Affiliations and Expertise

Advanced Imaging Unit of CNIC, Madrid, Spain

Jesus Ruiz-Cabello Editor

Jesús Ruiz-Cabello is currently Professor of Chemistry and Head of the Advanced Imaging Unit of the University of Madrid, Spain. He graduated in Chemistry from the University of Granada and obtained a doctorate in Physical Chemistry Pharmacy from the University of Madrid. Later he spent time at the National Institute of Health and Georgetown University after getting a Fulbright scholarship. His fundamental research is the field of Nuclear Magnetic Resonance (NMR) mainly towards the development of methods of ultrafast acquisition and hyperpolarization for molecular imaging. Current research is directed towards biomarkers (multimodality imaging, metabolic and different comics) and in the field of pulmonary and cardiovascular in general, and Pulmonary Hypertension (PH) in particular. He is co-author of over 160 articles and book chapters and co-inventor of four patents, two of them European, and he is the founding partner of a technology-based company Numio Technologies.

Affiliations and Expertise

Professor of Chemistry, Head of Advanced Imaging Unit, University of Madrid, Spain