Nucleic Acid Nanotheranostics

1. Introduction to Nanotheranostics for biomedical applications of nucleic acids

Part 1 Biomedical Applications of Nucleic Acids
2. Therapeutic nucleic acids- a state of the art
3. Application of Nucleic Acids in Cancer Therapy
4. Cardiovascular application of Nucleic Acids
5. Application of Nucleic Acids in Respiratory disease

Part 2 Diagnosis applications of Nucleic Acids
6. Circulating nucleic acids as biomarkers
7. Recent advances in the development of nucleic acid diagnostics

Part 3 Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery
8. Viral gene therapy
9. Non viral gene therapy: Peptiplexes
10. Non viral gene therapy:Lipoplexes
11. Non viral gene therapy: Polyplexes
12. Non viral gene therapy:Nanoplexes
13. Non viral gene therapy: Nucleic acid nanostructures

Part 4 Considerations of nanomedicine
14. Toxicological Aspects for Nanomaterial in Humans
15. Imaging of nucleic acid delivery
16. The state of investigational and approved nanomedicine products for nucleic acid delivery
17. Conclusion/Outlook

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.

• Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas
• Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging
• Presents the only book to include an analysis of nanoformulations approved for clinical use

Materials Scientists and Biochemists, Biomedical engineers, Clinicians, Pharmaceutical chemists, and researchers working on nanomaterials, especially those with healthcare applications