Nuclear Structure and Gene Expression - 1st Edition - ISBN: 9780121001605, 9780080537818

Nuclear Structure and Gene Expression

1st Edition

Nuclear Matrix and Chromatin Structure

Editors: R. Bird Wilfred Stein Jane Lian Janet Stein
eBook ISBN: 9780080537818
Imprint: Academic Press
Published Date: 18th November 1996
Page Count: 304
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Table of Contents

Introduction. S. Penman, B.J. Blencowe, and J.A. Nickerson, The Nuclear Matrix: Past and Present. Nuclear Matrix Structure and Function: R. Berezney, The Nuclear Matrix: Mapping Genomic Organization and Function in the Cell Nucleus. K.A. Mattern, R. van Driel, and L. de Jong, Composition and Structure of the Internal Nuclear Matrix. T. Kohwi-Shigematsu and Y. Kohwi, High Unwinding Capability of Matrix Attachment Regions and ATC-Sequence Context-Specific MAR-Binding Proteins. R.C. Bird, The Cyclin/Cyclin-Dependent Kinase Complex: Regulation of Cell Cycle Progression and Nuclear Disassembly. Chromatin Structure and Transcritpion Complexes: G.S. Stein, A.J. van Wijnen, J. Stein, J.B. Lian, and M. Montecino, Nuclear Architecture in Developmental Transcriptional Control of Cell Growth and Tissue-Specific Genes. D.G. Wansink, L. de Jong, and R. van Driel, Transcription by RNA Polymerase II and Nuclear Architecture. Nuclear mRNP Complexes: S.A. Amero and K.C. Sorensen, Protein Disposition on Nascent Pre-mRNA Transcripts. Chapter References. Subject Index.


Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.

Key Features

  • Mechanisms of interaction between nuclear structure and genes
  • Gene expression regulation by elements of the nuclear matrix
  • How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology


Ideal for cell biologists, molecular biologists, biochemists, and geneticists.


No. of pages:
© Academic Press 1997
Academic Press
eBook ISBN:


@qu:"This is an excellent book that should be in any life science or biomedical library. Researchers in the field of nuclear structure and gene expression may wish to own a copy of their own." @source:--Alvin Telser, Northwestern University Medical School, for DOODY PUBLISHING

Ratings and Reviews

About the Editors

R. Bird Editor

Affiliations and Expertise

Auburn University, Alabama

Wilfred Stein Editor

Wilfred Stein is the author of three previous books on membrane transport, the first appearing almost fifty years ago. He has edited numerous books and written some 180 papers on various aspects of membrane transport and especially transport kinetics. These papers, especially those written together with his colleague William Lieb, defined many of the concepts used today in discussing movement across cell membranes. More recently he has turned to the study of the kinetics of drugs used in cancer therapy and in the treatment of malaria. He has taught biochemistry, biophysics and physiology at the University of Manchester and the Hebrew University of Jerusalem and also at the Weizmann Institute in Israel. He is currently Emeritus Professor of Biophysics at the Hebrew University. He is married to a librarian and has four children and nine grandchildren.

Affiliations and Expertise

Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel

Jane Lian Editor

Affiliations and Expertise

University of Massachusetts Medical Center, Worcester

Janet Stein Editor

Affiliations and Expertise

University of Massachusetts Medical Center, Worcester