Description

A superb compilation of reviews from leading experts in the field of nuclear receptors, volume 16 in the Advances in Developmental Biology series covers the role of different nuclear receptor subfamilies in development, physiology and metabolism. This volume brilliantly reviews how genetic defects in the function of nuclear receptors leads to various developmental defects. Receptors discussed include: thyroid receptors, peroxisome proliferators activated receptors, and retinoic acid receptors. Additionaly, this volume offers an indespesable chapter on the orphan receptors Ftz-F1, COUPs, and RORs in embryonic and postnatal development.

Key Features

* Provides a compilation of reviews of several nuclear receptor subfamilies - such as TRs, PPARs, RARs, the orphan receptors COUP-TFs, RORs, and Ftz-F1 in embryonic and postnatal development. * Offers a detailed section on retinoid receptor signaling * Covers the role of co-repressors and co-activators in modulation of nuclear receptor functions

Readership

Developmental and cell biologists

Table of Contents

1. Developmental Roles of the Thyroid Hormone Receptor ¦¡ And ¦¢ Genes Lily Ng and Douglas Forrest 2. PPARs in fetal and early post-natal development Nicolas Rotman, Liliane Michalik, B¨¦atrice Desvergne, Walter Wahli 3. Regulation of murine embryonic patterning and morphogenesis by retinoic acid signaling Tracie Pennimpede, Don Cameron, and Martin Petkovich 4. Molecular mediators of retinoic acid signalling during development Karen Niederreither and Pascal Doll¨¦ 5. Hindbrain development and retinoids Joel C. Glover, Jean-S¨¦bastien Renaud, Xavier Lampe, and Filippo M. Rijli 6. Retinoid receptors in vertebral patterning Charlotte Rhodes and David Lohnes 7. Mouse Embryocarcinoma F9 cells and Retinoic Acid: A model to study the molecular mechanisms of endodermal differentiation Ga¨¦tan Bour, Reshma Taneja and C¨¦cile Rochette-Egly 8. The Ftz-F1 family: orphan nuclear receptors regulated by novel protein-protein interactions Leslie Pick, W. Ray Anderson, Jeffrey Shultz and Craig Woodard 9. Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor I in the Development of Nervous System Ke Tang, Fu-Jung Lin, Sophia Y. Tsai and Ming-Jer Tsai 10. Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development Anton M. Jetten and Joung Hyuck Joo 11. Hairless, a nuclear receptor corepressor essential for skin function Catherine C. Thompson and Gerard M. J. Beaudoin 12. Nuclear receptor transcriptional coactivators in development and metabolism Janardan K. Reddy, Dongshe

Details

No. of pages:
448
Language:
English
Copyright:
© 2006
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080469409
Print ISBN:
9780444528735
Print ISBN:
9780444558923

About the series-volume-editor

Reshma Taneja

Reshma Taneja obtained her Ph.D. at Indian Institute of Science in Bangalore working on gene transcription under the supervision of Professor KP Gopinathan. During the course of her postdoctoral training in Prof Pierre Chambon’s laboratory at the IGBMC in France she started working on a bHLH transcription factor Stra13, which was identified as a retinoic target gene. Her own laboratory initially at the Mount Sinai School of Medicine in New York, and currently at the National University of Singapore has had a long–standing interest in bHLH proteins and their ability to regulate cellular differentiation programs. Her group has made ground-breaking discoveries including generating Stra13-/- mice which first revealed its function in homeostasis of the immune system, as well as in skeletal muscle biology. In addition, her laboratory has identified novel transcriptional repression mechanisms mediated by recruitment of chromatin modifying enzymes that impact the function of bHLH factors in cellular differentiation. Currently, she holds an appointment at the Department of Physiology at the National University of Singapore and an adjunct appointment at the Mount Sinai School of Medicine. Her work has been well funded over the years from major funding bodies including the National Institutes of Health, The Muscular Dystrophy Association, March of Dimes Birth Defects Foundation, The Leukemia and Lymphoma Society, Lupus Research Foundation in the USA; and from National Medical Research Council, Singapore Stem Cell Consortium, and Ministry of Education in Singapore. She has won several honors and awards including the prestigious Scholar Award from the Leukemia and Lymphoma society. She serves as reviewer for several international funding agencies including NIH, NSF, NSERC Canada, Research Grants Council Hong Kong, Israel Science Foundation, Telethon, Association Française contre les Myopathies, French National Research Agency, and the National Medical Research Council Singapore

Affiliations and Expertise

Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore