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Nuclear Mechanics and Genome Regulation - 1st Edition - ISBN: 9780123810090, 9780123810106

Nuclear Mechanics and Genome Regulation, Volume 98

1st Edition

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Serial Volume Editor: G.V. Shivashankar
Hardcover ISBN: 9780123810090
eBook ISBN: 9780123810106
Imprint: Academic Press
Published Date: 10th September 2010
Page Count: 392
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Table of Contents

Section-A: Cell Nucleus: Organization & MechanoBiology

  1. Fluorescence Fluctuation Microscopy to reveal 3D-Architecture and Function in the Cell Nucleus
  2. Thorsten Lenser1,2, Klaus Weisshart2, Tobias Ulbricht3, Karolin Klement3, and Peter Hemmerich

  3. Studying histone modifications and their genomic functions by employing chromatin immunoprecipitation and immunoblotting
  4. Ranveer S. Jayani, Praveena L. Ramanujam and Sanjeev Galande

  5. Dynamic organization of chromatin assembly & transcription factories in living cells
  6. Bidisha Sinha, Dipanjan Bhattacharya, Deepak Kumar Sinha, Shefali Talwar,

    Shovamayee Maharana, Soumya Gupta and G. V.Shivashankar


  7. Manipulation & Isolation of Single Cells & Nuclei
  8. Swee Jin Tan, Qingsen Li and Chwee Teck Lim

  9. Beyond lamins: other structural components of the nucleoskeleton
  10. Zhixia Zhong , Katherine L. Wilson and Kris Noel Dahl

  11. Altered mechanical properties of the nucleus in disease
  12. Maria Lucia Lombardi and Jan Lammerding

  13. Theoretical concepts and models of cellular mechanosensing
  14. Rumi De, Assaf Zemel and Samuel A. Safran

    Section-B: Impact of Nuclear Mechanics on Function

  15. Mechanical Induction of Gene Expression in Connective Tissue Cells
  16. Mathew Chan, Boris Hinz, Christopher A. McCulloch

  17. Physical plasticity of the Nucleus and its manipulation
  18. Irena Ivanovska, Joe Swift, Takamasa Harada, J. David Pajerowski and Dennis E. Discher

  19. Prestressed Nuclear Organization in Living Cells
  20. Aprotim Mazumder, Roopa T. , Abhishek Kumar, K.Venkatesan Iyer,

    Nisha M Ramdas and G. V.Shivashankar

  21. Nanotopography/mechanical induction of stem-cell differentiation
  22. Evelyn Yim


  23. Mechanical Induction in Embryonic Development and Tumour Growth: Integrative Cues through Molecular to Multi-cellular Interplay, and Evolutionary Perspectives
  24. Maria-Elena Fernandez-Sanchez, Fanny Serman, Padra Ahmadi and Emmanuel Farge

  25. Informatics based analysis of mechanosignaling in the laminopathies
  26. Frank P.L. Lai, Radfidah A. Mutalif, Siew Cheng Phua, and Colin L. Stewart

  27. Autosomal Dominant Leukodystrophy caused by lamin B1 duplications: A clinical and molecular case study of altered nuclear function and disease

Quasar Saleem Padiath and Ying-Hui Fu


In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation.

Key Features

  • Both classic and state-of-the-art methods readily adaptable and designed to last the test of time
  • Relevant to clinicians and scientists working in a wide range of fields


Researchers and students in cell, molecular and developmental biology


No. of pages:
© Academic Press 2010
10th September 2010
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Volume Editor

G.V. Shivashankar

Dr. G. V. Shivashankar is currently the Deputy Director of Mechanobiology Institute, National University of Singapore. Shivashankar’s laboratory is focused on understanding the role of cell geometry on nuclear mechanics and genome regulation in living cells using a multi-disciplinary approach. He carried out his PhD research at the Rockefeller University (1994-1999) and Postdoctoral research at NEC Research Institute, Princeton, USA (1999-2000). He started his laboratory at the National Center for Biological Sciences, TIFR- Bangalore, India (2000-2009) before relocating to a tenured faculty position at the National University of Singapore in 2009. His scientific awards include the Birla Science Prize (2006) and the Swarnajayanthi Fellowship (2007), and he was elected to the Indian Academy of Sciences (2010). He also edited a Methods in Cell Biology volume on Nuclear Mechanics and Genome Regulation (2010), published by Elsevier. More recently, he headed the Joint Research Laboratory with the FIRC Institute of Molecular Oncology (IFOM), Milan, Italy and was appointed as an IFOM-NUS Chair Professor in 2014.

Affiliations and Expertise

Mechanobiology Institute, National University of Singapore & FIRC Institute of Molecular Oncology (IFOM), Milan, Italy