Nuclear Magnetic Resonance of Biological Macromolecules, Part C

Nuclear Magnetic Resonance of Biological Macromolecules, Part C

1st Edition - April 4, 2005
This is the Latest Edition
  • Editor: Thomas James
  • eBook ISBN: 9780080549477

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The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. Nuclear Magnetic Resonance of Biological Macromolecules, Part C is written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.

Key Features

* One of the most highly respected publications in the field of biochemistry since 1955
* Frequently consulted, and praised by researchers and reviewers alike
* Truly an essential publication for anyone in any field of the life sciences


Biochemists, cell biologists, molecular biologists, geneticists

Table of Contents

  • Identification and optimization of protein domains for NMR studies
    In-cell NMR spectroscopy
    Molecular Fragment Replacement Approach to Protein Structure Determination by Chemical Shift and Dipolar Homology Database Mining
    Cross-correlated relaxation for structure and dynamics
    Rapid NMR Data Collection
    An Integrated Platform for Automated Analysis of Protein NMR Structures
    Rapid Assessment of Protein Structural Stability and Fold Validation via NMR
    Determination of Protein Backbone Structures from Residual Dipolar Couplings
    Robotic Cloning and Protein Production Platform of the Northeast Structural Genomics Consortium
    Protein Structure Estimation From Minimal Restraints Using Rosetta
    Protein Structure Elucidation From Minimal Data: The CLOUDS and ABACUS Approaches
    Elucidation of the Protein Folding Landscape by NMR
    Membrane Protein Preparation for TROSY NMR Screening
    Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP
    NMR Experiments on Aligned Samplet of Membrane Proteins
    NMR techniques used with very large biological macromolecules in solution
    Structure determination of large biological RNAs
    Hydrodynamic Models and Computational Methods for NMR relaxation
    Solution NMR Spin Relaxation Methods for Characterizing Chemical Exchange in High Molecular Weight Systems
    Isotropic Reorientational Eigenmode Dynamics Complements NMR Relaxation Measurements for RNA
    NMR techniques for identifying the interface of a larger protein-protein complex: cross and transferred cross-saturation experiments
    Enzyme Dynamics During Catalysis Measured by NMR Spectroscopy
    Structure determination of protein/RNA complexes by NMR
    Utilization of NMR-derived fragment leads in drug design
    Discovery of Ligands by a Combination of Computational and NMR-based Screening: RNA as an Example Target

Product details

  • No. of pages: 672
  • Language: English
  • Copyright: © Academic Press 2005
  • Published: April 4, 2005
  • Imprint: Academic Press
  • eBook ISBN: 9780080549477
  • About the Serial Volume Editor

    Thomas James

    Affiliations and Expertise

    School of Pharmacy, University of California, San Francisco, U.S.A.