The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 250 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.


Biochemists, biophysicists, molecular biologists, and pharmaceutical researchers.

Table of Contents

DNA and RNA Structure: U. Schmitz and T.L. James, How to Generate Accurate Solution Structures of Double-Helical Nucleic Acid Fragments Using Nuclear Magnetic Resonance and Restrained Molecular Dynamics. B.A. Luxon and D.G. Gorenstein, Comparison of X-ray and NMR-Determined Nucleic Acid Structures. P.K. Radha, R. Nibedita, R.A. Kumar, and R.V. Hosur, Distance Geometry in NMR Determination of Solution Conformation of Nucleic Acids: Application to d-ACCGTTAACGGT. N.B. Ulyanov and T.L. James, Statistical Analysis of DNA Duplex Structural Features. M.A. Young, J. Srinivasan, I. Goljer, S. Kumar, D.L. Beveridge, and P.H. Bolton, Structure Determination and Analysis of Local Bending in an A-Tract DNA Duplex: Comparison of Results from Crystallography, Nuclear Magnetic Resonance, and Molecular Dynamics Simulation on d(CGCAAAAATGCG). G.V. Fazakerley and Y. Boulard, DNA Mismatches and Modified Bases. G. Carlstrim, S.-m. Chen, S. Miick, and W.J. Chazin, NMR Studies of Complex DNA Structures: The Holliday Junction Intermediate in Genetic Recombination. N.B. Leontis, M.E. Piotto, M.T. Hills, A. Malhotra, I.V. Ouporov, J.M. Nussbaum, and D.G. Gorenstein, Structural Studies of DNA Three-Way Junctions. M.W. Germann, N. Zhou, J.H. van de Sande, and H.J. Vogel, Parallel-Stranded Duplex DNA: An NMR Perspective. J. Feigon, K.M. Koshlap, and F.W. Smith, 1H NMR Spectroscopy of DNA Triplexes and Quadruplexes. C.-L. Juang, P.Tang, and G.S. Harbison, Solid-State NMR of DNA. P.F. Agris and S.C. Brown, Systems for the NMR Study of Modified Nucleoside-Dependent, Metal-Ion Induced Conformational Changes in Nucleic Acids. R.T. Batey, J.L. Battiste, and J.R. Williamson, Preparation of Is


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© 1995
Academic Press
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@from:Praise for the Series @qu:"The Methods in Enzymology series represents the gold-standard." @source:--NEUROSCIENCE @qu:"Incomparably useful." @source:--ANALYTICAL BIOCHEMISTRY @qu:"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page." @source:--BIO/TECHNOLOGY @qu:"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection." @source:--CHEMISTRY IN INDUSTRY @qu:"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced." @source:--AMERICAN SOCIETY OF MICROBIOLOGY NEWS @qu:"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work." @source:--ENZYMOLOGIA @qu:"A series that has established itself as a definitive reference for biochemists." @source:--JOURNAL OF CHROMATOGRAPHY