LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organizat… Read more
LIMITED OFFER
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field.
The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.
PART I - CHROMATIN ORGANIZATION AND DYNAMICS
1. DNA mechanics
2. DNA supercoiling (omics)
3. Chromatin and chromosome folding (experiments)
4. Chromatin and chromosome folding (modeling)
5. Chromatin and chromosome physics
6. ncRNA in chromatin folding
7. Insulators
8. Condensins and cohesins
9. Long range interactions
10. Crowding
PART II - NUCLEAR ENVELOPE, NUCLEAR BODIES AND NUCLEOCYTOPLASMIC TRAFFICKING
11. Nuclear bodies
12. Nucleolus
13. Transcription factories
14. Polycomb bodies
15. Nuclear lamina
16. Other components of the nucleoskeleton
17. Nuclear pores
18. Nuclear traffic
PART III - MAIN NUCLEAR FUNCTIONS
19. Chromatin folding and DNA replication
20. Chromatin folding and DNA repair
21. Chromatin folding and transcription
22. Chromatin folding and recombination
23. Chromatin folding and differentiation
24. Nuclear mechanics and mechanotransduction
25. Altered nucleus and disease
PART IV - SPECIFIC FEATURES OF NUCLEAR ORGANIZATION IN MAIN MODEL ORGANISMS
26. Yeast nucleus
27. Nematode nucleus
28. Drosophila nucleus
29. Plant nucleus
Conclusion and perspectives by the editors
CL
JV