Nuclear Architecture and Dynamics
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Nuclear Architecture and Dynamics

1st Edition - October 20, 2017

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  • Editors: Christophe Lavelle, Jean-Marc Victor
  • Hardcover ISBN: 9780128034804
  • eBook ISBN: 9780128035030

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Description

Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.

Key Features

  • Highlights the link between the (bio)chemistry and the (bio)physics of chromatin
  • Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin
  • Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds

Readership

Geneticists, clinical researchers, life science researchers, (bio)physicists and molecular/cellular biologists, advanced undergraduate and graduate students in genetics, molecular biology, cell biology, and biophysics

Table of Contents

  • PART I - CHROMATIN ORGANIZATION AND DYNAMICS
    1. DNA mechanics
    2. DNA supercoiling (omics)
    3. Chromatin and chromosome folding (experiments)
    4. Chromatin and chromosome folding (modeling)
    5. Chromatin and chromosome physics
    6. ncRNA in chromatin folding
    7. Insulators
    8. Condensins and cohesins
    9. Long range interactions
    10. Crowding

    PART II - NUCLEAR ENVELOPE, NUCLEAR BODIES AND NUCLEOCYTOPLASMIC TRAFFICKING
    11. Nuclear bodies
    12. Nucleolus
    13. Transcription factories
    14. Polycomb bodies
    15. Nuclear lamina
    16. Other components of the nucleoskeleton
    17. Nuclear pores
    18. Nuclear traffic

    PART III - MAIN NUCLEAR FUNCTIONS
    19. Chromatin folding and DNA replication
    20. Chromatin folding and DNA repair
    21. Chromatin folding and transcription
    22. Chromatin folding and recombination
    23. Chromatin folding and differentiation
    24. Nuclear mechanics and mechanotransduction
    25. Altered nucleus and disease

    PART IV - SPECIFIC FEATURES OF NUCLEAR ORGANIZATION IN MAIN MODEL ORGANISMS
    26. Yeast nucleus
    27. Nematode nucleus
    28. Drosophila nucleus
    29. Plant nucleus
    Conclusion and perspectives by the editors

Product details

  • No. of pages: 618
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: October 20, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128034804
  • eBook ISBN: 9780128035030

About the Editors

Christophe Lavelle

Christophe Lavelle, Volume Editor, is a research scientist at the CNRS (National Center for Scientific Research), principal investigator at the National Museum of Natural History in Paris. His studies mostly concern the biophysical properties of DNA and dynamical processes at task in the nucleus. He teaches biophysics and epigenetics in several universities (Paris VI, Paris VII, Aix-Marseille, Lyon, Lille, Toulouse) and is a member of the American and the French Biophysical Societies.

Affiliations and Expertise

Research Scientist, National Center for Scientific Research (CNRS), Principal Investigator, National Museum of Natural History, Paris, France

Jean-Marc Victor

Jean-Marc Victor, Volume Editor, is a research director at the CNRS, principal investigator at the University Pierre et Marie Curie - Paris VI (part of Sorbonne University). His studies mostly concern the physics of chromosomes (theory and simulations) and the modeling of nuclear processes, with special attention to epigenetics and chronic diseases.

Affiliations and Expertise

Research Director, National Center for Research Science (CNRS), Principal Investigator, University Pierre et Marie Curie, Paris, France

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