Novel Therapeutic Approaches Targeting Oxidative Stress

Novel Therapeutic Approaches Targeting Oxidative Stress

1st Edition - February 18, 2022

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  • Editors: Pawan Maurya, Imteyaz Qamar
  • Paperback ISBN: 9780323909051
  • eBook ISBN: 9780323909068

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Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.

Key Features

  • Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer
  • Covers a range of therapeutic approaches to target oxidative stress
  • Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress
  • Features case studies illustrating the targeting of oxidative stress


Researchers and clinicians working in the area of oxidative stress, such as molecular biologists, biochemists, cell biologists, and pharmacologists. PhD and postgraduate students in biomedical sciences and those working with oxidative stress and related fields

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • Preface
  • Acknowledgments
  • Chapter 1: Novel therapeutic approaches targeting oxidative stress in mood disorders
  • Abstract
  • 1: Introduction
  • 2: The production of ROS in the brain
  • 3: The elimination of ROS in the brain
  • 4: Oxidative stress in the brain
  • 5: Markers of oxidative stress and mood disorders
  • 6: Antioxidant treatments in mood disorders
  • 7: Conclusions
  • Chapter 2: Ferroptosis: Oxidative stress and pathophysiology
  • Abstract
  • Acknowledgment
  • Conflict of interest
  • 1: Introduction
  • 2: Immunology
  • 3: Conclusion
  • Chapter 3: Oxidative stress and its biological significance
  • Abstract
  • 1: Introduction
  • 2: Oxidative stress in 4-hydroxynonenal (HNE) leading to apoptosis
  • 3: Antioxidant supplementation increasing tumorigenesis
  • 4: Regulation of the cell cycle in the oxidative state
  • 5: Viral infections and oxidative stress
  • 6: Epigenetic factors and carcinogenesis
  • 7: Extracellular superoxide angles and apoptosis
  • 8: Extreme oxidative stress with T cells
  • 9: Oxidative stress in lung cancer
  • 10: Inflammation and lung cancer
  • 11: Oxidative stress in breast cancer
  • 12: Response to therapy
  • Chapter 4: Novel therapeutic approaches targeting oxidative stress in aging
  • Abstract
  • Acknowledgments
  • 1: Introduction
  • 2: Hallmarks of aging
  • 3: Causes of aging
  • 4: Age-associated diseases
  • 5: Novel therapeutic approaches
  • 6: Liposomes
  • 7: Conclusion
  • Chapter 5: Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases
  • Abstract
  • Acknowledgment
  • Conflicts of interest/competing interests
  • 1: Introduction
  • 2: Dimensions of aging in the investigation of neurodegeneration
  • 3: Clinical implications
  • 4: Implications for research
  • Chapter 6: The role of oxidative stress in kidney diseases
  • Abstract
  • 1: Introduction
  • 2: Kidney architecture at the cellular level
  • 3: Nephrotoxicity and renal pathology
  • 4: Classification of kidney diseases
  • 5: The chemical species of oxidative stress
  • 6: Cellular antioxidant defense system
  • 7: Sources of ROS in the kidneys
  • 8: Reactive oxygen species and kidney diseases
  • 9: Oxidative stress in the renal tubules
  • 10: Oxidative stress in the glomerulus
  • 11: Oxidative stress in the renal vasculature
  • 12: Role of ROS in ischemia and reperfusion (I/R)-induced acute kidney injury
  • Chapter 7: The role of oxidative stress and antioxidants across the spectrum of acute coronary syndrome
  • Abstract
  • 1: Introduction
  • 2: Oxidative stress
  • 3: Endothelial dysfunction and oxidative stress
  • 4: Molecular effects of oxidative stress
  • 5: Oxidative stress in coronary artery disease
  • 6: Coronary microvascular dysfunction
  • 7: Oxidative stress and lipids, protein, and DNA damage
  • 8: Therapies for oxidative stress-associated cardiovascular diseases
  • 9: Conclusions
  • Chapter 8: Biosensors in the detection of oxidative stress using discovered biomarkers
  • Abstract
  • Acknowledgments
  • 1: Introduction
  • 2: Biosensors
  • 3: Biomarkers
  • 4: Overview of discovered biomarkers for oxidative stress
  • 5: Management of oxidative stress conditions
  • 6: Research trends and future challenges in development of biosensors
  • 7: Conclusion
  • Chapter 9: Biochemical approaches/methods in the detection of free radicals
  • Abstract
  • 1: Introduction
  • 2: In vitro methods
  • 3: Chemiluminescence-derived methods using luciferine derivatives
  • 4: Reduction of cytochrome c
  • 5: NBT tests
  • 6: Aconitase inactivation
  • 7: Boronates
  • 8: In vivo methods
  • 9: Redox potential of the GSH/GSSG couple
  • 10: Measurement of F2-isoprostanes as indicators of lipid per-oxidation
  • 11: Reporter assays
  • 12: Fluorescent protein-based methods
  • 13: Analytical methods
  • 14: Fluorescence-dependent methods
  • 15: Electron spin resonance (ESR) or electron paramagnetic resonance (EPR) spectroscopy
  • 16: Spin trapping technique
  • 17: Immuno-spin trapping of macromolecules
  • 18: Combined IST and mMRI detection
  • 19: Pulse radiolysis
  • 20: Chromatography-based techniques
  • 21: Other biochemical methods
  • 22: Summary
  • Chapter 10: Novel therapeutic approaches targeting oxidative stress in breast and lung cancer
  • Abstract
  • Acknowledgments
  • 1: Introduction
  • 2: Epidemiology and risk factors
  • 3: Role of oxidative stress in cancer pathophysiology
  • 4: Classification of breast and lung cancer
  • 5: Conventional therapies for cancer treatment
  • 6: Novel approaches for cancer therapeutics
  • 7: Therapeutic approaches targeting oxidative stress in cancer
  • 8: Conclusion
  • 9: Future perspective
  • Chapter 11: Advancements in novel drug delivery systems: Providing a challenge and threat to oxidative stress in various diseases
  • Abstract
  • 1: Introduction
  • 2: Anti-oxidants working principle and pathways
  • 3: Types of anti-oxidants and their mode of action
  • 4: Traditional approaches
  • 5: Innovative approaches in nano delivery of natural and synthetic anti-oxidants
  • 6: Limitations and future perspectives of novel drug delivery systems at clinical translation level
  • 7: Summary
  • Index

Product details

  • No. of pages: 292
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: February 18, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323909051
  • eBook ISBN: 9780323909068

About the Editors

Pawan Maurya

Prof. Pawan Kumar Maurya is Dean, School of Life Long Learning & Head of Department of Biochemistry, Central University of Haryana, India. He has done a PhD from the University of Allahabad (A Central University), India & post-doctoral training from Universidade Federal de Sao Paulo-UNIFESP, Brazil; Taipei Medical University (TMU) and National Taiwan University (NTU), Taiwan. He has more than 14 years of teaching and research experience. He is working on biochemical diagnostics, nanomedicine, and clinical biochemistry. He has published over 75 research articles in reputed journals. He has also edited of six books published from Elsevier, USA and Springer-Nature, Singapore. He is recipient of prestigious fellowships: Science without Borders (Government of Brazil) and National Science Council, Taiwan.

Affiliations and Expertise

Central University of Haryana, Mahendergarh (Haryana), INDIA

Imteyaz Qamar

Dr. Imteyaz Qamar is working as an assistant professor at School of biotechnology, Gautam Buddha University, Greater Noida, India. His area on interest is Stress biology, and Cancer Genetics He earned his Ph.D. in Molecular Endocrinology from Chonnam National University, South Korea with an emphasis on gene regulation and physiological function of an androgen receptor corepressor-19kD using mice model. He has written various manuscripts, grants, progress reports, pre-IND protocols, animal protocols and published in well reputed international journals. He has also received various awards such as Brain Korea-21 Best Research presenter award 2007, Bharath Vikas award 2016, Young Scientist Award 2017 & 2019, STE meritorious award 2019 etc. He serves as a member of editorial boards of various peer reviewed journals. He is also a member of the endocrinology society, United States of America (USA).

Affiliations and Expertise

Assistant Professor, School of Biotechnology, Gautam Buddha University, Greater Noida, Gautam Buddha Nagar, Uttar Pradesh, India

Ratings and Reviews

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  • Anand Thu Oct 20 2022

    Oxidative stress therapeutic potential

    Overall well-written textbook and clear figures adequate of supporting the written text

  • Aditi S. Thu Oct 20 2022

    Detailed topics on biochemistry

    Being from biochemistry background the book proves helpful in clearing all the concepts very thoroughly…other important topics are also covered in this book…I will definitely recommend this book to the people working in the area of cancer research.