Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative…Read more
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Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored.
The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.
Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer
Covers a range of therapeutic approaches to target oxidative stress
Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress
Features case studies illustrating the targeting of oxidative stress
Researchers and clinicians working in the area of oxidative stress, such as molecular biologists, biochemists, cell biologists, and pharmacologists. PhD and postgraduate students in biomedical sciences and those working with oxidative stress and related fields
2: Dimensions of aging in the investigation of neurodegeneration
3: Clinical implications
4: Implications for research
Chapter 6: The role of oxidative stress in kidney diseases
Abstract
1: Introduction
2: Kidney architecture at the cellular level
3: Nephrotoxicity and renal pathology
4: Classification of kidney diseases
5: The chemical species of oxidative stress
6: Cellular antioxidant defense system
7: Sources of ROS in the kidneys
8: Reactive oxygen species and kidney diseases
9: Oxidative stress in the renal tubules
10: Oxidative stress in the glomerulus
11: Oxidative stress in the renal vasculature
12: Role of ROS in ischemia and reperfusion (I/R)-induced acute kidney injury
Chapter 7: The role of oxidative stress and antioxidants across the spectrum of acute coronary syndrome
Abstract
1: Introduction
2: Oxidative stress
3: Endothelial dysfunction and oxidative stress
4: Molecular effects of oxidative stress
5: Oxidative stress in coronary artery disease
6: Coronary microvascular dysfunction
7: Oxidative stress and lipids, protein, and DNA damage
8: Therapies for oxidative stress-associated cardiovascular diseases
9: Conclusions
Chapter 8: Biosensors in the detection of oxidative stress using discovered biomarkers
Abstract
Acknowledgments
1: Introduction
2: Biosensors
3: Biomarkers
4: Overview of discovered biomarkers for oxidative stress
5: Management of oxidative stress conditions
6: Research trends and future challenges in development of biosensors
7: Conclusion
Chapter 9: Biochemical approaches/methods in the detection of free radicals
Abstract
1: Introduction
2: In vitro methods
3: Chemiluminescence-derived methods using luciferine derivatives
4: Reduction of cytochrome c
5: NBT tests
6: Aconitase inactivation
7: Boronates
8: In vivo methods
9: Redox potential of the GSH/GSSG couple
10: Measurement of F2-isoprostanes as indicators of lipid per-oxidation
11: Reporter assays
12: Fluorescent protein-based methods
13: Analytical methods
14: Fluorescence-dependent methods
15: Electron spin resonance (ESR) or electron paramagnetic resonance (EPR) spectroscopy
16: Spin trapping technique
17: Immuno-spin trapping of macromolecules
18: Combined IST and mMRI detection
19: Pulse radiolysis
20: Chromatography-based techniques
21: Other biochemical methods
22: Summary
Chapter 10: Novel therapeutic approaches targeting oxidative stress in breast and lung cancer
Abstract
Acknowledgments
1: Introduction
2: Epidemiology and risk factors
3: Role of oxidative stress in cancer pathophysiology
4: Classification of breast and lung cancer
5: Conventional therapies for cancer treatment
6: Novel approaches for cancer therapeutics
7: Therapeutic approaches targeting oxidative stress in cancer
8: Conclusion
9: Future perspective
Chapter 11: Advancements in novel drug delivery systems: Providing a challenge and threat to oxidative stress in various diseases
Abstract
1: Introduction
2: Anti-oxidants working principle and pathways
3: Types of anti-oxidants and their mode of action
4: Traditional approaches
5: Innovative approaches in nano delivery of natural and synthetic anti-oxidants
6: Limitations and future perspectives of novel drug delivery systems at clinical translation level
7: Summary
Index
No. of pages: 292
Language: English
Edition: 1
Published: February 18, 2022
Imprint: Academic Press
Paperback ISBN: 9780323909051
eBook ISBN: 9780323909068
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Pawan Kumar Maurya
Prof. Pawan Kumar Maurya is Dean, School of Life Long Learning & Head of Department of Biochemistry, Central University of Haryana, India. He has done a PhD from the University of Allahabad (A Central University), India & post-doctoral training from Universidade Federal de Sao Paulo-UNIFESP, Brazil; Taipei Medical University (TMU) and National Taiwan University (NTU), Taiwan. He has more than 14 years of teaching and research experience. He is working on biochemical diagnostics, nanomedicine, and clinical biochemistry. He has published over 75 research articles in reputed journals. He has also edited of six books published from Elsevier, USA and Springer-Nature, Singapore. He is recipient of prestigious fellowships: Science without Borders (Government of Brazil) and National Science Council, Taiwan.
Affiliations and expertise
Central University of Haryana, Mahendergarh (Haryana), INDIA
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Imteyaz Qamar
Dr. Imteyaz Qamar is working as an assistant professor at School of biotechnology, Gautam Buddha University, Greater Noida, India. His area on interest is Stress biology, and Cancer Genetics
He earned his Ph.D. in Molecular Endocrinology from Chonnam National University, South Korea with an emphasis on gene regulation and physiological function of an androgen receptor corepressor-19kD using mice model. He has written various manuscripts, grants, progress reports, pre-IND protocols, animal protocols and published in well reputed international journals. He has also received various awards such as Brain Korea-21 Best Research presenter award 2007, Bharath Vikas award 2016, Young Scientist Award 2017 & 2019, STE meritorious award 2019 etc. He serves as a member of editorial boards of various peer reviewed journals. He is also a member of the endocrinology society, United States of America (USA).
Affiliations and expertise
Assistant Professor, School of Biotechnology, Gautam Buddha University, Greater Noida, Gautam Buddha Nagar, Uttar Pradesh, India
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