Novel Psychoactive Substances

Novel Psychoactive Substances

Classification, Pharmacology and Toxicology

2nd Edition - September 6, 2021

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  • Editors: Paul Dargan, David Wood
  • Hardcover ISBN: 9780128187883
  • eBook ISBN: 9780128190302

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Novel Psychoactive Substances: Classification, Pharmacology and Toxicology, Second Edition provides readers with a comprehensive examination on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." The book covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance and a discussion of their associated acute and chronic harm and toxicity. This second edition addresses drugs new to the scene, with completely updated and revised chapters. Written by international experts in the field, this multi-authored book is an essential reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

Key Features

  • Includes chapters written by international experts in the field
  • Presents a comprehensive overview on the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance
  • Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies
  • Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene, including amphetamines and the synthetic cannabinoid receptors in ‘spice’ and ‘K2’


Research scientists and academics in pharmacology and toxicology and biochemists, healthcare professionals, including physicians, nurses and paramedics, law enforcement and legislative authorities

Table of Contents

  • I. Background
    1. Legal Classification and International Systems for Monitoring Novel Psychoactive Substances
    2. Availability and Supply of Novel Psychoactive Substances
    3. Prevalence of Use of Novel Psychoactive Substances
    4. Pharmacological Profiling of Novel Psychoactive Substances
    5. Novel methods of NPS detection and data triangulation
    6. Social issues in the use of novel psychoactive substances
    7. General management of the patient with Novel Psychoactive Substance Toxicity
    8. Addiction and treatment of Novel Psychoactive Substance dependence

    II. Analytical Techniques
    9. Analytical techniques for the detection of novel psychoactive substances and their metabolites

    III. Individual Novel Psychoactive Substances
    10. Synthetic Amphetamines derivatives, benzofurans, and benzodifurans

    11. Pharmacology and Toxicology of N-Benzyl-phenylethylamines (25X-NBOMe) Hallucinogens
    12. 1-Benzylpiperazine and other Piperazine-based stimulants
    13. Synthetic Cathinones
    14. Arylcyclohexamines
    15. Synthetic cannabinoids (SC)
    16. Novel synthetic opioids
    17. Novel benzodiazepines
    18. Tryptamines

Product details

  • No. of pages: 554
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: September 6, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128187883
  • eBook ISBN: 9780128190302

About the Editors

Paul Dargan

Professor Dargan and Dr Wood are both expert advisors on novel psychoactive substances to expert bodies in the UK (Advisory Council on the Misuse of Drugs, ACMD), Europe (European Monitoring Centre for Drugs and Drug Addiction, EMCDDA) and Worldwide (United Nations Office on Drugs and Crime, UNODC). They run a clinical service managing patients with acute drug toxicity, and have a clinical and research interest in novel psychoactive substances. They publish widely in this field and have both been invited to give keynote lectures at International meetings on this topic.

Affiliations and Expertise

Consultant Physician and Professor of Clinical Toxicology, London, UK

David Wood

David Wood is a Consultant Physician and Clinical Toxicologist at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

Affiliations and Expertise

Consultant Physician and Clinical Toxicologist, Reader in Clinical Toxicology, London, UK

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