Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials and molecular platforms for drug delivery, from hydrogels, nanocarriers and metal-organic-frameworks, to ꞵ-cyclodextrin and polyphosphazene. Each chapter discusses the benefits and limitations of each drug delivery system, as well as toxicological and safety implications. This book offers an interdisciplinary approach to this fast-moving topic, bridging the disciplines of materials science and pharmacology.
Provides an up-to-date single resource on novel drug delivery platforms, a rapidly evolving field of research
Covers a broad range of materials, systems and release mechanisms, including in vivo and in vitro studies
Describes the synthesis, properties, formulation and application of various novel drug delivery systems
Materials scientists, pharmaceutical scientists
Table of Contents
1. Introduction: state of the art, new challenges, and opportunities for drug delivery and its application 2. Drug delivery application: an outlook on past and present technologies 3. General mechanisms of drug loading and sustained release 4. Supramolecular hydrogels as drug delivery systems for nerve regeneration and wound healing 5. Molecularly imprinted polymeric carriers for controlled drug release 6. Engineered extracellular vesicles as drug delivery systems for the next generation of nanomedicine 7. Polyelectrolyte multilayer films for cancer therapy 8. Porous metal9. Stimulus-responsive liposomes as smart nanocarriers for drug delivery applications 10. Hybrid platforms for drug delivery applications 11. Self-nanoemulsifying drug delivery systems with bioavailability potential 12. Graphene-based nanomaterials for targeted drug delivery and tissue engineering 13. Bionanocomposites as a new platform for drug delivery systems 14. Nanotube platforms for effective drug delivery applications 15. Biodegradable polymeric nanoparticle drug for oral delivery applications 16. Delivery of radiopharmaceuticals and theranostic agents: targeted alpha therapy 17. Controlled drug release and drug delivery applications from mesoporous nanoparticles 18. Porous nanostructured metal oxides as potential scaffolds for drug delivery 19. Thin films as an emerging platform for drug delivery 20. Modeling and simulation in drug delivery 21. In-vivo drug release studies 22. Toxicity measurement and toxicity studies of drug delivery 23. Nasal and pulmonary routes of drug delivery 24. “Gene therapy”: ethical and regulatory issues 25. New challenges in drug discovery
Dr. Sangita Das is working as Newton International Fellow at Durham University, England, United Kingdom. She also works as a visiting professor in the Department of Energy Science in Mahatma Gandhi University, Kerala, India. She received her B. Sc. degree with honors in chemistry in 2008 from the University of Calcutta, Kolkata, West Bengal, India. She obtained her M. Sc. degree in chemistry with organic specialization in 2010 from the same university. She had qualified the all India (CSIR–JRF) NET, and then she joined “The Goswami Group,” Department of Chemistry, IIEST for her doctoral work under the supervision of Prof. Shyamaprosad Goswami. She got Ph.D. in 2016. Her areas of research interest include molecular recognition; design of fluorescence chemosensors; and characterization of fluorescence probe (detection of metal ions, anions, reactive oxygen species, nerve gas, and other environmentally hazardous species, etc.); aggregation-induced emission dyes and solid-state emitters, and synthesis of compounds with antidiabetic activity. She is now working as a Newton International Fellow in the United Kingdom. Her current research activities include the development of compounds as HDAC inhibitors, experimental and theoretical investigations of electronic structure of transition metal complexes with redox noninnocent ligands, and computational chemistry (DFT, TDDFT calculations).
Affiliations and Expertise
Royal Society Newton International Fellow, Department of Chemistry, Durham University, Durham, United Kingdom
Post-doctoral research fellow, Durham University, England, UK
Prof. Sabu Thomas is one of India’s most renowned scientists known for his contributions in polymer science and nanotechnology. He is a scientist, administrator and a teacher of national and international students. He joined Cochin University of Science and Technology, India, to pursue his bachelor’s degree in polymer science and rubber technology.
He went on to complete his Ph. D. at the Indian Institute of Technology, Kharagpur, India. After attaining industrial experience, he returned to Mahatma Gandhi University, India, as a lecturer. He currently serves as the Vice Chancellor of the Mahatma Gandhi University.
He has guided over 116 Ph. D students. He has received several national and international awards for best researcher and is a member of numerous scientific bodies and committees. He has been honoured with honorary doctorates from University of South Brittany, France; University of Lorraine, France and Siberian Federal University, Russia. He has authored more than 1,200 research publications and 156 books. He has been ranked 114th in the list of the world’s best scientists (Stanford University, USA). He was also selected for the DST Nanomission award 2020. He received Honorary Professorship from Siberian Federal University in 2020. Last year he was honoured with C.N.R Rao Award Prize Lecture in Advanced Materials by Materials Research Society of India (MRSI). He was elected as the Foreign Fellow of the European Academy of Sciences (EurASc)-2019. In 2022 he was honoured the Bailey Medal Award and in 2021 was awarded the Kairali Lifetime Research Award 2021 by the Kerala government.
Affiliations and Expertise
Vice Chancellor, Mahatma Gandhi University, Kerala, India.
Dr. Partha Pratim Das is presently working as a postdoctoral researcher in Seoul National University, South Korea. He previously worked in the Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea, as a postdoctoral researcher. He has completed both the B.Sc. (2008) and M.Sc. (2010) in chemistry from Calcutta University, India. He has received Ph.D. in science (chemistry) in 2016 from Jadavpur University, India. His working laboratories during Ph.D. are CSIR-CGCRI, Kolkata, and CSIR-NCL, Pune, India. His research area is focused on nanotechnology, synthesis, and structure–properties correlation studies of different multifunctional nanomaterials under various conditions for mainly clean and sustainable energy and environmental applications. He has published several high-impact papers in peer-reviewed journals. Moreover, his research works have been acclaimed in many national and international conferences and journal societies.
Affiliations and Expertise
Postdoctoral researcher, Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea