Normal and Malignant Cell Growth - 1st Edition - ISBN: 9781483198637, 9781483223667

Normal and Malignant Cell Growth

1st Edition

Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer

Editors: R. J. M. Fry M. L. Griem W. H. Kirsten
eBook ISBN: 9781483223667
Imprint: Butterworth-Heinemann
Published Date: 1st January 1969
Page Count: 252
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Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

Table of Contents



List of Participants

Normal Cell Kinetics

General Introduction

Proliferative Capacity of Hemopoietic Stem Cells

Discussion: Colony Forming Units in the Bone Marrow of Partial Body Irradiated Mice

Cellular Proliferation in the Liver

Discussion: Cellular Proliferation in the Liver

Cell Proliferation in the Intestinal Epithelium

Discussion: Proliferation of Gastrointestinal Cells

General Discussion

Proliferation of Antibody Forming Cells

Discussion: Proliferation of Antibody Forming Cells

Composition of Cell Life Cycle

Discussion: Methods and Criteria of Mammalian Cell Synchrony

Susceptibility of Intestinal Crypt Epithelium to Hydroxyurea and Other Antitumor Agents

Discussion: Mammalian Cell Killing by Inhibitors of DNA Synthesis

Proliferation of Cancer Cells

General Introduction: The Growth of Tumor Cells under Normal and Fasting Conditions

Cell Proliferation during Carcinogenesis

Comparison Between the Rates of Proliferation of Induced Malignancies and Their Normal Tissues of Origin

The Use of Three-Dimensional Matrix Tissue Culture for Bioassay of Cancer

Discussion: The Use of Three-Dimensional Matrix Tissue Culture for Bioassay of Cancer

Importance of the Non-Dividing Leukemia Cell

Discussion: Magnitude of Proliferating Fraction and Rate of Proliferation of Populations of Leukemic Cells in Man

Incorporation of Iodine-Labeled 5-Iodo-2'-Deoxyuridine into D N A of Mouse Mammary Tumors

In Vivo Cell Kinetics of Human Cancers

Summary: H. M. PATT

Round-Table Discussion


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© Butterworth-Heinemann 1969
eBook ISBN:

About the Editor

R. J. M. Fry

M. L. Griem

W. H. Kirsten

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