Normal and Malignant Cell Growth

Normal and Malignant Cell Growth

Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer

1st Edition - January 1, 1969

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  • Editors: R. J. M. Fry, M. L. Griem, W. H. Kirsten
  • eBook ISBN: 9781483223667

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Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

Table of Contents

  • Preface


    List of Participants

    Normal Cell Kinetics

    General Introduction

    Proliferative Capacity of Hemopoietic Stem Cells

    Discussion: Colony Forming Units in the Bone Marrow of Partial Body Irradiated Mice

    Cellular Proliferation in the Liver

    Discussion: Cellular Proliferation in the Liver

    Cell Proliferation in the Intestinal Epithelium

    Discussion: Proliferation of Gastrointestinal Cells

    General Discussion

    Proliferation of Antibody Forming Cells

    Discussion: Proliferation of Antibody Forming Cells

    Composition of Cell Life Cycle

    Discussion: Methods and Criteria of Mammalian Cell Synchrony

    Susceptibility of Intestinal Crypt Epithelium to Hydroxyurea and Other Antitumor Agents

    Discussion: Mammalian Cell Killing by Inhibitors of DNA Synthesis

    Proliferation of Cancer Cells

    General Introduction: The Growth of Tumor Cells under Normal and Fasting Conditions

    Cell Proliferation during Carcinogenesis

    Comparison Between the Rates of Proliferation of Induced Malignancies and Their Normal Tissues of Origin

    The Use of Three-Dimensional Matrix Tissue Culture for Bioassay of Cancer

    Discussion: The Use of Three-Dimensional Matrix Tissue Culture for Bioassay of Cancer

    Importance of the Non-Dividing Leukemia Cell

    Discussion: Magnitude of Proliferating Fraction and Rate of Proliferation of Populations of Leukemic Cells in Man

    Incorporation of Iodine-Labeled 5-Iodo-2'-Deoxyuridine into D N A of Mouse Mammary Tumors

    In Vivo Cell Kinetics of Human Cancers

    Summary: H. M. PATT

    Round-Table Discussion

Product details

  • No. of pages: 252
  • Language: English
  • Copyright: © Butterworth-Heinemann 1969
  • Published: January 1, 1969
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483223667

About the Editors

R. J. M. Fry

M. L. Griem

W. H. Kirsten

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