Nonviral Vectors for Gene Therapy, Part 1, Volume 53

2nd Edition

Editors: Leaf Huang Mien-Chie Hung Ernst Wagner
Hardcover ISBN: 9780120176533
eBook ISBN: 9780080915739
Imprint: Academic Press
Published Date: 7th July 2005
Page Count: 392

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Table of Contents

Recent Advances in Non-viral Gene Delivery; Barriers to gene delivery using synthetic vectors; Pharmacokinetics of Plasmid DNA-Based Nonviral Gene Medicine; What Role can chemistry play in cationic liposome-based gene therapy research today?; Lipoplex structures and their distinct cellular pathways; Toxicity of Catonic lipid-DNA complexes; Polyethylenimine (PEI); Pluronic Block Copolymers for gene delivery; Terplex gene delivery system; Design of polyphosphoester-DNA nanoparticles for nonviral gene delivery; Development of HVJ envelope vector and its application to gene therapy; Targeting of polyplexes: towards synthetic virus vector systems.

Description

The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therapeutics are fully covered in these volumes.

Readership

Graduate students, scientists, and clinicians interested in molecular and cell biology interested in gene therapy.


Details

No. of pages:
392
Language:
English
Copyright:
© Academic Press 2005
Published:
Imprint:
Academic Press
eBook ISBN:
9780080915739
Hardcover ISBN:
9780120176533

About the Editors

Leaf Huang Editor

Affiliations and Expertise

Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina, U.S.A.

Mien-Chie Hung Editor

Affiliations and Expertise

M.D. Anderson Cancer Center, University of Texas, Houston, U.S.A.

Ernst Wagner Editor

Affiliations and Expertise

Munich Center for System-based Drug Research, Center for Nanoscience, Ludwig-Maximilians-Universität, Germany