Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research

Biology and Management

2nd Edition - March 29, 2012

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  • Editors: Christian Abee, Keith Mansfield, Suzette Tardif, Timothy Morris
  • Hardcover ISBN: 9780123813657
  • eBook ISBN: 9780123978370

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Description

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.

Key Features

  • Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use
  • Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research
  • Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information

Readership

Researchers working with nonhuman primates and those dealing with laboratory animal husbandry; Veterinarians in private practice who work with nonhuman primates; Biologists and zoologists who wish to expand their knowledge of nonhuman primates

Table of Contents

  • American College of Laboratory Animal Medicine Series

    Preface

    Acknowledgments

    Reviewers

    Contributors

    Chapter 1. History of the Use of Nonhuman Primates in Biomedical Research

    Human and Nonhuman Primates to 1960

    Establishment of the National Institutes of Health’s National Primate Research Centers Program in the USA: Crossing the Threshold

    1960–1980: Period of Growth in a World of Increasing Constraints

    1980S and 1990S: Progress Paying off in the Face of Serious Challenges

    Primate Research Beyond the Year 2000

    Looking Toward the Future

    Chapter 2. Laws, Regulations and Policies Relating to the Care and Use of Nonhuman Primates in Biomedical Research

    Introduction

    National Laws on Use of Nonhuman Primates in Biomedical Research

    Nonlegislative Initiatives that Affect the Care and Use of Nonhuman Primates

    Good Laboratory and Manufacturing Practice

    Human and Animal Disease Control

    Species Conservation

    Transport

    Health and Safety

    Appendix 1

    Chapter 3. Taxonomy of Nonhuman Primates Used in Biomedical Research

    Introduction

    Biomedically Relevant Primate Species

    The Old World Primates

    The New World Primates

    From Phylogenetics to Phylogenomics

    Acknowledgment

    Chapter 4. Functional Morphology

    Introduction

    Morphological Definition of Primate Order

    Sexual Dimorphism

    Growth and Development

    Body Size and Integument

    Head and Neck Morphology

    Back and Spine Morphology

    Limb Morphology

    Thoracic Morphology

    Abdominal and Pelvic Morphology

    Perineal Morphology

    Conclusions

    Acknowledgments

    Selected Readings

    Chapter 5. Study of Nonhuman Primate Social Behavior

    Introduction

    Levels of Behavioral Analysis

    Definition of Nonhuman Primate Societies

    General Statement on Nonhuman Primate Social Structures

    Methodologies used to Study Behavior

    Behavior Research to Colony Management

    Conclusions

    Chapter 6. Behavioral Management, Enrichment, and Psychological Well-being of Laboratory Nonhuman Primates

    Introduction

    Definitions of Terms

    Why Perform Behavioral Management?

    Managing Behavior

    Environmental Enrichment Plans

    Positive Reinforcement Training

    Balancing Psychological Well-Being and Research Needs

    Managing Behavioral Management Programs

    Conclusions

    Acknowledgments

    Chapter 7. Behavioral Disorders of Nonhuman Primates

    Introduction

    Etiology of Psychological Disorders

    Therapeutic Strategies for Reversing Psychopathology

    A Practical Guide to Managing Abnormal Behavior in the Laboratory

    Summary

    Acknowledgments

    Chapter 8. Reproduction and Breeding of Nonhuman Primates

    Basic Reproductive Biology

    Housing, Husbandry, and Population Management for Breeding

    Pregnancy Management

    Nonhuman Primates from Foreign Breeding Programs

    Chapter 9. Laboratory Housing of Nonhuman Primates

    Introduction

    Primary Housing Design for Individuals, Pairs, or Small Groups

    Group Enclosures

    Security

    Conclusion

    Acknowledgments

    Chapter 10. Nutrient Requirements and Dietary Husbandry Principles for Captive Nonhuman Primates

    Introduction

    Primate Nutrient Requirements

    Considerations for Feeding Protocols

    Chapter 11. Animal Identification and Record Keeping for Nonhuman Primates

    Introduction

    Animal Identification

    Record Keeping

    Data and Database Format

    Reports and Analyses

    Summary

    Acknowledgments

    Chapter 12. Preventative Medicine in Nonhuman Primates

    Introduction

    Occupational Health and Safety

    Quarantine

    Husbandry Measures Contributing to Preventive Health

    Disease Surveillance

    Animal Vaccination Program

    Chapter 13. Clinical Techniques used for Nonhuman Primates

    Introduction

    Handling

    Digestive System

    Urinary System

    Respiratory System

    Reproductive System

    Circulatory System

    Central Nervous System

    Musculoskeletal System

    Integumentary System

    Body Cavities

    Chapter 14. Surgery in Nonhuman Primates

    Introduction

    Nonclinical Concerns

    General Principles of Experimental Surgery

    Chapter 15. Emergency Medicine and Critical Care for Nonhuman Primates

    Introduction

    General

    Emergencies and Diseases Common to Nonhuman Primates Requiring Critical Care

    Chapter 16. Xenotransplantation

    Introduction

    History

    Pathobiology of Pig-To-Primate Organ Transplantation

    The Pig-to-Nonhuman Primate Model

    Results and Complications

    Genetic Modification of Pigs

    Summary

    Acknowledgments

    Chapter 17. Anesthesia and Analgesia in Nonhuman Primates

    Introduction

    Preanesthetic Considerations

    Selecting an Anesthetic Regime

    Anesthetic Management and Monitoring

    Dealing with Emergencies

    Special Considerations

    Postanesthetic Care

    Analgesia

    Chapter 18. Biosafety in Laboratories using Nonhuman Primates

    General Biosafety Considerations

    Disease Prevention

    Facilities Management

    Equipment

    Personnel Management

    Veterinary Care, Animal Health, and Husbandry Practices

    Zoonoses, Biohazards, and Other Health Risks

    Viral Diseases

    Bacterial Diseases

    Spirochetal Diseases

    Mycoplasmal Diseases

    Rickettsial Diseases

    Chlamydial Diseases

    Mycotic Diseases

    Parasitic Diseases

    Model Occupational Health Program for Persons Working with Nonhuman Primates

    Participants

    Components

    Records

    Health Services/Personnel

    Acknowledgments

    Chapter 19. Safety and Efficacy Evaluation Using Nonhuman Primates

    History and Regulation of Primate Testing

    Nonhuman Primate Models of Safety Assessment

    Efficacy Studies in the Nonhuman Primate

    Index

Product details

  • No. of pages: 536
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: March 29, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123813657
  • eBook ISBN: 9780123978370

About the Editors

Christian Abee

Affiliations and Expertise

University of Texas, MD Anderson Cancer Center, Michale E. Keeling Center for Comparative, Medicine and Research, Bastrop, Texas, U.S.A.

Keith Mansfield

Keith Mansfield is Associate Director for Resource and Collaborative Affairs and Chair, Division of Primate Resources, New England National Primate Research Center, Harvard Medical School, Harvard University, Southborough, US. His research focuses on primarily on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis.

Affiliations and Expertise

Novartis Institutes for Biomedical Research,Cambridge, MA, U.S.A.

Suzette Tardif

Suzette D. Tardif, Ph.D., is the Associate Director of Research at the Southwest National Primate Research Center. She is an adjunct faculty of The Barshop Institute. The Tardif laboratory's activities center on the development of the marmoset monkey as a disease model. Dr. Tardiff is a past-President of the American Society of Primatologists.

Affiliations and Expertise

Barshop Institute for Longevity & Aging Studies, San Antonio, TX USA

Timothy Morris

Affiliations and Expertise

The School of Veterinary Medicine and Science, The University of Nottingham, Leicestershire, UK

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