Non-Neuronal Cells of the Nervous System: Function and Dysfunction, Volume 31

1st Edition

Part I: Structure, Organization, Development and Regeneration Part II: Biochemistry, Physiology and Pharmacology Part III: Pathological Conditions

Authors: L. Hertz
Hardcover ISBN: 9780444514516
eBook ISBN: 9780080930459
Imprint: Elsevier Science
Published Date: 8th December 2003
Page Count: 1300
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Table of Contents

Part I. Structure, Organization and Development. 1. Cytoarchitectonics of non-neuronal cells in the nervous system (J.R. Wolff. T.I. Chao). 2. Oligodendrocyte phenotypical and morphological heterogeneity: a reexamination of old concepts in view of new findings (S. Szuchet, M.A. Seeger). 3. Regulation of cell cycle progression in astrocytes (Y. Naktsuji, R.H. Miller).

  1. Role of neuron-glia interactions (F.C. Alcantara Gomes, S.K. Rehen). 5. Cells lining the ventricular system: evolving concepts underlying developmental events in the embryo and adult (F.G. Szele, S. Szuchet). 6. The perisynaptic astrocyte process as a glial compartment - immunolabelling for glutamine synthetase and other glial markers (A. Derouiche). 7. The astrocytic syncytium (E. Scemes, D.C. Spray). 8. Structural plasticity of non-neuronal cells in the hypothalamo-neurohypophyseal system: in the right place at the right time (A.K. Salm, A.E. Ayoub, B.E. Lally). 9. Glial-neuronal-endothelial interactions and the neuroendocrine control of GnRH secretion (V. Prévot, S. De Serrano, C. Estrella). 10. Meninges and perivasculature as mediators of CNS plasticity (F. Mercier, G.I. Hatton). 11. Mechanisms of infiltration of immune cells, bacteria and viruses through brain endothelium (P.O. Couraud, X. Nassif, S. Bourdolos). 12. Hydrocephalus disorders: their biophysical and neuroendocrine impact on the choroids plexus epithelium (C.E. Weaver, J.A. Duncan et al.). 13. Schwann cell interactions with axons and CNS glial cells during optic nerve regeneration (M. Dezawa).
  2. Control of microglial activity by protective autoimmunity (M. Schwartz). 15. Roles of retinal macroglia in maintaining the stability of the retina (J. Stone, K. Valter). 16. Function and dysfunction of enteric glia (T.C. Savidge, J. Cabarrocas, R.S. Liblau). Part II. Biochemistry, Physiology and Pharmacology. 1. A role of lactate released from astrocytes in energy pr


The brain, and the rest of the nervous system, consists of nerve cells (neurons) and non-neuronal cells (glial cells), which by far outnumber the neurons, but in the past have received much less attention.

This began to change about 30 years ago with the realization that glial cells carry out very important functions, generally in collaboration with the nerve cells. Evidence is now starting to accumulate that glial cells, especially astrocytes and microglia, may be major (in some cases the main) players in a multitude of neurological and mental diseases, and that different types of glial cells interact not only with nerve cells but also with each other and with cells lining brain tissue and controlling exchange of nutrients and other compounds between the brain and the rest of the body. Understanding of these interactions during normal function and in disease states is hampered by the fact that general knowledge of cellular interactions during brain function is limited.

These books present an attempt to remedy this situation. In the first two volumes, basic information about cell types and biochemical and physiological interactions between these cells is provided by leading experts in the field, and in the last part emerging evidence of the importance of such cellular interactions in several of the most important neurological and mental diseases is presented by leading researchers working actively in the field in question.


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About the Authors

L. Hertz Author

Affiliations and Expertise

Gilmour, Ontario, Canada