Non-Canonical Autophagy

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies.

• Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy
• Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes
• Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Researchers, graduate students, and professionals actively working in the field of autophagy research across molecular biology, biochemistry, cell biology, and biomedical sciences. Medical researchers

Chapter 1. Introduction: canonical vs non-canonical autophagy

Chapter 2. Overview of Canonical Autophagy
2.1 Introduction
2.2 Overview of the main autophagic processes
2.3 Molecular components of the autophagy core machinery and signaling pathways
2.4 Autophagosomes formation, maturation and fusion

Chapter 3. Overview of Non-Canonical Autophagy
3.1 Introduction
3.2 ULK-1-independent autophagy
3.3 Beclin 1-indipendent, VSPS34-independent and VPS34/VPS15-independent Autophagy
3.4 Ubiquitin-like conjugation actors-independent autophagy
3.5 Non-canonical mitophagy
3.5 The unconventional functions of ATG proteins

Chapter 4. LC3-associated phagocytosis (LAP)
4.1 Introduction
4.2 Molecular divergences between canonical autophagy and LAP
4.3 Role of LAP in immunity and inflammation
4.4 Role of LAP in anti-cancer immune response

Chapter 5. Autophagy-dependent cell death (ADCD)
5.1 Introduction
5.2 Types of ADCD and their distinguishing features: excessive autophagy, excessive mitophagy and autosis
5.3 The key signals regulating ADCD
5.4 Role of ADCD in physiological and pathophysiological conditions
5.5 Induction of ADCD by anti-cancer agents. Facts and controversies

Chapter 6. Therapeutic targeting of non-conventional autophagy: potential benefits and pitfalls
6.1 Introduction
6.2 Therapeutic targeting of autophagy in neurodegenerative disease
6.3 Targeting autophagy in aging and cardiovascular diseases
6.4 Autophagy as a therapeutic target for autoimmune disorders
6.5 Targeting autophagy in cancer