
Non-Canonical Autophagy
Mechanisms and Pathophysiological Implications
Description
Key Features
- Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy
- Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes
- Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
Readership
Researchers, graduate students, and professionals actively working in the field of autophagy research across molecular biology, biochemistry, cell biology, and biomedical sciences. Medical researchers
Table of Contents
Chapter 1. Introduction: canonical vs non-canonical autophagy
Chapter 2. Overview of Canonical Autophagy
2.1 Introduction
2.2 Overview of the main autophagic processes
2.3 Molecular components of the autophagy core machinery and signaling pathways
2.4 Autophagosomes formation, maturation and fusionChapter 3. Overview of Non-Canonical Autophagy
3.1 Introduction
3.2 ULK-1-independent autophagy
3.3 Beclin 1-indipendent, VSPS34-independent and VPS34/VPS15-independent Autophagy
3.4 Ubiquitin-like conjugation actors-independent autophagy
3.5 Non-canonical mitophagy
3.5 The unconventional functions of ATG proteinsChapter 4. LC3-associated phagocytosis (LAP)
4.1 Introduction
4.2 Molecular divergences between canonical autophagy and LAP
4.3 Role of LAP in immunity and inflammation
4.4 Role of LAP in anti-cancer immune responseChapter 5. Autophagy-dependent cell death (ADCD)
5.1 Introduction
5.2 Types of ADCD and their distinguishing features: excessive autophagy, excessive mitophagy and autosis
5.3 The key signals regulating ADCD
5.4 Role of ADCD in physiological and pathophysiological conditions
5.5 Induction of ADCD by anti-cancer agents. Facts and controversiesChapter 6. Therapeutic targeting of non-conventional autophagy: potential benefits and pitfalls
6.1 Introduction
6.2 Therapeutic targeting of autophagy in neurodegenerative disease
6.3 Targeting autophagy in aging and cardiovascular diseases
6.4 Autophagy as a therapeutic target for autoimmune disorders
6.5 Targeting autophagy in cancer
Product details
- No. of pages: 182
- Language: English
- Copyright: © Academic Press 2021
- Published: April 21, 2021
- Imprint: Academic Press
- eBook ISBN: 9780128209110
- Paperback ISBN: 9780128205389
About the Editors
Giulia Petroni
Affiliations and Expertise
Lorenzo Galluzzi
