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Nociceptin Opioid - 1st Edition - ISBN: 9780128024430, 9780128025932

Nociceptin Opioid, Volume 97

1st Edition

Serial Editor: Gerald Litwack
Hardcover ISBN: 9780128024430
eBook ISBN: 9780128025932
Imprint: Academic Press
Published Date: 6th February 2015
Page Count: 358
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Table of Contents

Chapter One: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception

  • Abstract
  • 1 Nociception in Brief
  • 2 Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1–17)
  • 3 Other Modifications to Nociceptin(1–17)
  • 4 The Importance of Structure in Nociceptin Analogues
  • 5 Recent Advances in ORL-1 Active Nociceptin Peptides
  • 6 The Development of New Helix-Constrained Nociceptin Analogues
  • 7 Biological Properties of Helical Nociceptin Mimetics
  • 8 Concluding Remarks

Chapter Two: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors

  • Abstract
  • 1 Introduction
  • 2 The Vertebrate Opioid Receptor Sequence Database
  • 3 The Human Genome and the Evolution of Opioid Receptors
  • 4 The Molecular Evolution of Vertebrate Opioid Family Receptors
  • 5 Future Directions
  • 6 Conclusions
  • Acknowledgments

Chapter Three: Ancestral Vertebrate Complexity of the Opioid System

  • Abstract
  • 1 Introduction
  • 2 Opioid Peptide Family
  • 3 Opioid Receptor Family
  • 4 Discussion: Complexity, Coevolution, and Divergence
  • 5 Conclusions
  • Acknowledgement

Chapter Four: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors’ Ligands: View on Current Developments

  • Abstract
  • 1 Introduction
  • 2 Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands
  • 3 Hexapeptides with NOP Receptor Affinity
  • 4 Solid-Phase Peptide Synthesis
  • 5 Conclusions
  • Acknowledgment

Chapter Five: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein

  • Abstract
  • 1 Introduction
  • 2 Biological Activity by NST Through G Protein-Coupled Receptor
  • 3 Pain Regulation Through an NST-Interacting Protein
  • 4 Conclusions
  • Acknowledgment

Chapter Six: Nociceptin and Meiosis during Spermatogenesis in Postnatal Testes

  • Abstract
  • 1 Introduction
  • 2 Regulation of Nociceptin Expression by FSH Signaling in Sertoli Cells
  • 3 Function of Nociceptin During Meiosis in Spermatocytes
  • 4 Nociceptin is a Novel Paracrine Factor that is Induced in Sertoli Cells and Mediates to Germ Cells the Effect of FSH on Spermatogenesis
  • 5 Nociceptin is a Novel Extrinsic Factor Inducing Rec8 Phosphorylation and Chromosome Dynamics During Meiosis in Spermatocytes
  • 6 Conclusions
  • Acknowledgments

Chapter Seven: Orphanin FQ-ORL-1 Regulation of Reproduction and Reproductive Behavior in the Female

  • Abstract
  • 1 Introduction
  • 2 Ovarian Hormone Regulation of Reproductive Behavior and Neuroendocrine Feedback Loops
  • 3 OFQ/N-ORL-1 Regulation of Sexual Receptivity
  • 4 Ovarian Steroid Regulation of OFQ/N and ORL-1 Expression and Signaling
  • 5 OFQ/N-ORL-1 Regulation of GnRH and LH Release During Positive and Negative Feedback
  • 6 Conclusions
  • Acknowledgments

Chapter Eight: Effects of Nociceptin and Nocistatin on Uterine Contraction

  • Abstract
  • 1 Roles of PNOC, N/OFQ, and NST in Different Peripheral Tissues
  • 2 Presence of PNOC, N/OFQ, and NST in Uterine Tissue
  • 3 The Effects and Mechanisms of Action of N/OFQ and NST on Uterine Contractility
  • 4 Conclusions

Chapter Nine: Nociceptin/Orphanin FQ-NOP Receptor System in Inflammatory and Immune-Mediated Diseases

  • Abstract
  • 1 A Brief Overview of the Immune Response
  • 2 N/OFQ and Its Receptor
  • 3 N/OFQ and NOP Receptor Expression in Leukocytes
  • 4 Effects of NOP Receptor Activation on the Immune Response
  • 5 NOP Receptor Activation and Inflammatory and Autoimmune Diseases
  • 6 Molecular Mechanisms Underlying N/OFQ Actions on Immune Functions
  • 7 Relationship Between N/OFQ, Stress, and HPA Axis
  • 8 Conclusions
  • Acknowledgments

Chapter Ten: Endogenous Nociceptin System Involvement in Stress Responses and Anxiety Behavior

  • Abstract
  • 1 Introduction
  • 2 The Neuroanatomical Basis of Fear Conditioning
  • 3 Evidence for a Role of Nociceptin in Fear Learning and Memory
  • 4 Nociceptin and Neurochemical Substrates of Fear Conditioning: Focus on Biogenic Amines
  • 5 Maternal Adaptations of the Nociceptin System
  • 6 Conclusions

Chapter Eleven: The Neuronal Circuit Between Nociceptin/Orphanin FQ and Hypocretins/Orexins Coordinately Modulates Stress-Induced Analgesia and Anxiety-Related Behavior

  • Abstract
  • 1 Introduction
  • 2 The N/OFQ System
  • 3 The Hypocretins/Orexins System
  • 4 Interaction Between the N/OFQ and Hcrt Systems
  • 5 Conclusions
  • Acknowledgments

Chapter Twelve: Nociceptin/Orphanin-FQ Modulation of Learning and Memory

  • Abstract
  • 1 Introduction
  • 2 N/OFQ Modulation of Mnemonic Functions
  • 3 Mechanisms of N/OFQ-Mediated Modulation of Cognitive Functions
  • 4 Conclusion and Remarks
  • Acknowledgments


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on nociceptin opioid.

Key Features

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels
  • Three-dimensional structures in color
  • Elaborate signaling pathways


Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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© Academic Press 2015
6th February 2015
Academic Press
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About the Serial Editor

Gerald Litwack

Gerald Litwack

Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA