
NMR Metabolomics in Cancer Research
Description
Key Features
- Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics
- Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications
- Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types
Readership
Table of Contents
List of figures
List of tables
Abbreviations
About the author
Chapter 1: Introduction
Abstract:
1.1 Possibilities of NMR metabolomics in cancer research
Chapter 2: Biology – cancer metabolic phenotype
Abstract:
2.1 Cancer metabolic phenotype
2.2 Drugs aimed at cancer metabolic phenotype
Chapter 3: Experimental methodology
Abstract:
3.1 Fundamentals of NMR spectroscopy
3.2 1D NMR in mixture analysis
3.3 Multidimensional NMR in metabolomics
3.4 Arrayed NMR experiments
3.5 Isotope labeling for NMR analysis
3.6 Diagnostic magnetic resonance tools based on cancer metabolic phenotype and cancer-induced metabolic changes
Chapter 4: Metabolomics NMR data preprocessing – analysis of individual spectrum
Abstract:
4.1 NMR spectrum preprocessing
4.2 Qualitative metabolomics
4.3 STOCSY
4.4 Quantitative metabolomics
4.5 Novel metabolite structure analysis
Chapter 5: Metabolomics data analysis – processing and analysis of a dataset
Abstract:
5.1 Normalization and scaling
5.2 Biases and confounders in metabolomics
5.3 Data analysis
5.4 Data integration – polyomics analysis
Chapter 6: Dynamic metabolic profiling and metabolite network and pathways modeling
Abstract:
6.1 Dynamic metabolic data analysis
6.2 Computational models of metabolic networks
Chapter 7: Biomarker discovery
Abstract:
7.1 Feature (biomarkers) selection
7.2 Validation of results in supervised analysis
Chapter 8: NMR metabolomics application by cancer type
Abstract:
8.1 Breast cancer
8.2 Brain cancers
8.3 Lung cancer metabolomics analysis and results
8.4 Metabolomics analysis of biofluids in cancer research
Chapter 9: Perspectives
Index
Product details
- No. of pages: 446
- Language: English
- Copyright: © Woodhead Publishing 2012
- Published: December 17, 2012
- Imprint: Woodhead Publishing
- eBook ISBN: 9781908818263
- Hardcover ISBN: 9781907568848
About the Author
Miroslava Čuperlović-Culf
Affiliations and Expertise
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