This volume provides a novel insight to the evolutionary and comparative aspects of nitric oxide- nitric oxide synthase system as a central regulator of invertebrate and vertebrate homeostasis. By critically selecting and summarizing the ever–increasing number of original studies, these presentations review a variety of important signalling and modulatory roles played by nitric oxide at molecular, cell, organ and organ system levels. It addresses not only specialists and graduate students in the field, but also all biologists concerned with how this unique, gaseous, pleiotropic molecule has been employed by living systems, uncovering a new dimension of the wonders of life.


Experimental biologists, researchers in developmental cell and comparative biology within animal and plant biology.

Table of Contents

1. On the Comparative Biology of NO Synthetic Pathways: Parallel Evolution of NO-Mediated Signaling Leonid L. Moroz and Andrea B. Kohn 2. Nitric Oxide Biogenesis, Signalling and Roles in Molluscs: The Sepia officinalis Paradigm Anna Palumbo and Marco d’Ischia 3. Soluble Guanylyl Cyclases in Invertebrates: Targets for NO and O2 David B. Morton and Anke Vermehren 4. Nitric Oxide Signalling in Insect Epithelial Transport Shireen-A. Davies 5. Nitric Oxide/Cyclic GMP Signaling and Insect Behavior Ralf Heinrich and Geoffrey K. Ganter 6. Impact of Nitrative/Nitrosative Stress in Mitochondria: Unraveling Targets for Malaria Chemotherapy Shirley Luckhart, Kazunobu Kato and Cecilia Giulivi 7. Effects of S-Nitrosation of Nitric Oxide Synthase Douglas A. Mitchell, Thomas Michel and Michael A. Marletta 8. Regulatory Role and Evolution of Unconventional NOS-Related RNAs Sergei Korneev and Michael O’Shea 9. The Role of Blood Nitrite in the Control of Hypoxic Vasodilation Angela Fago and Frank B. Jensen 10. Nitrite is a Vascular Store of NO which Mediates Hypoxic Signaling and Protects against Ischemia/Reperfusion Injury Cameron Dezfulian, Mark T. Gladwin and Sruti Shiva 11. Nitric Oxide and the Zebrafish (Danio rerio): Developmental Neurobiology and Brain Neurogenesis Bo Holmqvist, Lars Ebbe


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© 2007
Elsevier Science
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