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Nitric Oxide - 1st Edition - ISBN: 9780128002544, 9780128004395

Nitric Oxide, Volume 96

1st Edition

Serial Editor: Gerald Litwack
Hardcover ISBN: 9780128002544
eBook ISBN: 9780128004395
Imprint: Academic Press
Published Date: 8th August 2014
Page Count: 454
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Table of Contents

  • Former Editors
  • Preface
  • Chapter One: Regulation of Nociceptive Transduction and Transmission by Nitric Oxide
    • Abstract
    • 1 Introduction
    • 2 Role of NO in Nociceptive Transduction at the Periphery
    • 3 Diverse Effects of NO on Ion Channels Expressed on Primary Sensory Neurons
    • 4 Role of NO in Regulating Nociceptive Transmission at the Spinal Cord Level
    • 5 NO Reduces Excitatory, But Potentiates Inhibitory, Synaptic Transmission in Spinal Cords
    • 6 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Two: microRNA and Human Inducible Nitric Oxide Synthase
    • Abstract
    • 1 Introduction
    • 2 Regulation of Human iNOS Gene
    • 3 miRNAs Regulation
    • 4 Conclusion
  • Chapter Three: Heart Mitochondrial Nitric Oxide Synthase: A Strategic Enzyme in the Regulation of Cellular Bioenergetics
    • Abstract
    • 1 Introduction
    • 2 Heart Mitochondrial NO Production
    • 3 Regulation of Heart mtNOS
    • 4 Effects of NO on Heart Mitochondrial Function
    • 5 Physiopathological Regulation of Heart mtNOS
    • 6 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Four: Nitric Oxide Regulation of Adult Neurogenesis
    • Abstract
    • 1 Introduction
    • 2 Adult Neurogenesis
    • 3 Expression of NOS in Neurogenic Regions
    • 4 Pharmacological Studies of NO on Adult Neurogenesis In Vivo
    • 5 NOS Knockout Animals and Adult Neurogenesis
    • 6 Neuropeptide Y and NO
    • 7 The Dual Role of NO in Adult Neurogenesis
    • 8 Concentration-Dependent Effects of NO
    • 9 Conclusions
  • Chapter Five: Nitric Oxide in the Nervous System: Biochemical, Developmental, and Neurobiological Aspects
    • Abstract
    • 1 Introduction
    • 2 NO Signaling Pathways
    • 3 NO and Neuronal Viability
    • 4 NO and Neurotransmitters Release
    • 5 NO and Neuroplasticity
  • Chapter Six: Hippocampus and Nitric Oxide
    • Abstract
    • 1 Introduction
    • 2 Profiles of NO in the CNS
    • 3 NO and Hippocampal Plasticity
    • 4 NO and the Related CNS Disorders
    • 5 Conclusion
  • Chapter Seven: Nitric Oxide and Hypoxia Signaling
    • Abstract
    • 1 Introduction
    • 2 Part 1: NO Biology in Normoxia, Hypoxia, and Anemia
    • 3 Part 2: Effects of Hypoxia on NOSs
    • 4 Summary
  • Chapter Eight: NO Binding to the Proapoptotic Cytochrome c–Cardiolipin Complex
    • Abstract
    • 1 Introduction
    • 2 The cyt c–CL Complex
    • 3 Ligand Binding to the cyt c/CL Complex
    • 4 Insights into the Nature and Formation of the Proximal NO Complex in cyt c–CL
    • 5 Conclusions
  • Chapter Nine: The Nitric Oxide-Mediated Regulation of Prostaglandin Signaling in Medicine
    • Abstract
    • 1 Introduction
    • 2 NOS and NO Production
    • 3 COX and Prostaglandin in Biology
    • 4 The Role of Nitric Oxide in Prostaglandin Regulation
    • 5 Perspective/conclusion
  • Chapter Ten: Nitric Oxide as a Mediator of Estrogen Effects in Osteocytes
    • Abstract
    • 1 Introduction
    • 2 Bone-Protective Effects of Estrogen
    • 3 Induction of NO Synthesis by Estrogen
    • 4 NO/cGMP Signaling in Bone Cells
    • 5 Bone-Anabolic Effects of NO in Humans—Lessons from Clinical Trials
    • 6 Estrogen Promotion of Osteocyte Survival via the NO/cGMP/PKG Pathway
    • Acknowledgment
  • Chapter Eleven: Insights into the Diverse Effects of Nitric Oxide on Tumor Biology
    • Abstract
    • 1 Introduction
    • 2 Cellular Reactions of NO
    • 3 Conclusion/Discussion
  • Chapter Twelve: Dual Effect of Interferon (IFNγ)-Induced Nitric Oxide on Tumorigenesis and Intracellular Bacteria
    • Abstract
    • 1 Introduction
    • 2 Interferon γ
    • 3 NOS2/NO
    • 4 L-Arg Metabolism
    • 5 NOS2/NO in Disease
    • 6 IFNγ-Induced NO as a Mechanism to Inhibit Renal Cancer Growth
    • 7 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Thirteen: Antiobesogenic Role of Endothelial Nitric Oxide Synthase
    • Abstract
    • 1 Introduction
    • 2 eNOS is Important for Regulating Vascular and Metabolic Function
    • 3 NO Bioavailability is Decreased in Obese and Diabetic States
    • 4 Regulation of Obesity and Insulin Resistance by eNOS
    • 5 Synopsis
    • Acknowledgments
  • Chapter Fourteen: Nitric Oxide and Cerebrovascular Regulation
    • Abstract
    • 1 Introduction
    • 2 Sources of NO in the Neurovascular Unit
    • 3 Resting CBF
    • 4 Autoregulation
    • 5 Neurovascular Coupling (Fig. 14.1)
    • 6 Conclusion
    • Acknowledgments
  • Chapter Fifteen: Endothelial Nitric Oxide Synthase Gene Polymorphisms in Cardiovascular Disease
    • Abstract
    • 1 Introduction
    • 2 Genetic Variants
    • 3 eNOS Polymorphisms in CVD
    • 4 eNOS Polymorphisms in Other Diseases
    • 5 Conclusion
  • Chapter Sixteen: Role of Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension
    • Abstract
    • 1 Role of NO in Vasorelaxation and Proliferation in PH
    • 2 Endothelial Nitric Oxide Synthase Expression and its Activity in Relationship to the Vasoreactivity
    • 3 Physiological Role of NO in Pulmonary Hypertension
    • 4 Use of NO in Patients with PH in Clinical Practice
    • 5 Clinical Application of NO Inhalation in Patients with Pulmonary Hypertension
  • Index


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones.  A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on nitric oxide.

Key Features

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels
  • Three-dimensional structures in color
  • Elaborate signaling pathways


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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© Academic Press 2014
8th August 2014
Academic Press
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Ratings and Reviews

About the Serial Editor

Gerald Litwack

Gerald Litwack

Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA