Nitric Oxide

Nitric Oxide

Biology and Pathobiology

2nd Edition - November 5, 2009

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  • Editor: Louis Ignarro
  • eBook ISBN: 9780080920443

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Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

Key Features

  • Edited by Nobel Laureate Louis J. Ignarro
  • Up-to-date therapeutic implications of nitric oxide research
  • Authored by world experts on nitric oxide
  • Detailed research of the biochemistry and synthesis of nitric oxide


Researchers and students in biochemistry, cardiology, cell and molecular biology, neuroscience, pharmacology, endocrinology. Will also be an interest to academic clinicians in dermatology, neurology, oncology, etc.

Table of Contents

  • Section I. Chemical Biology

    Chapter 1

    Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes

    Chapter 2

    Nitric oxide redox biochemistry in lipid environments

    Chapter 3

    Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration

    Chapter 4

    Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes

    Section II. Principles of Biology

    A. Nitric Oxide Synthases

    Chapter 5

    Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal

    Chapter 6

    Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases

    Chapter 7

    Regulation of the expression of inducible nitric oxide synthase

    Chapter 8

    Molecular Regulation of Inducible Nitric Oxide Synthase

    B. Guanylate Cyclase and Cyclic GMP

    Chapter 9

    Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation

    C. Nitric Oxide Signaling

    Chapter 10

    Untargeted Discovery of NO-modified Proteins 

    Chapter 11

    Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids

    Chapter 12

    Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1

    Chapter 13

    The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide

    D. Regulation of Nitric Oxide Production

    Chapter 14

    Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence

    E. Nitric Oxide and Remodeling

    Chapter 15

    The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies

    F. Nitrite and Nitrate

    Chapter 16

    NO formation from inorganic nitrate and nitrite

    Chapter 17

    Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential

    Chapter 18

    Nitrite Therapy for Ischemic Syndromes

    Chapter 19

    Nitrite and heme globins: Reaction mechanisms and physiological targets

    Section III. Principles of Pathobiology

    A. Nitric Oxide and Cardiovascular Function

    Chapter 20

    Nitric Oxide in Vascular Damage and Regeneration

    Chapter 21

    Free radicals as atherosclerotic risk-The relation of NO-

    Chapter 22

    The role of oxidative stress in endothelial dysfunction and vascular inflammation

    B. Pathophysiological Mechanisms of Nitric Oxide

    Chapter 23

    Nitric oxide, oxidative stress, immune response and critical care

    Chapter 24

    Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury

    Chapter 25

    Nitric oxide in airway inflammation

    Chapter 26

    Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance



Product details

  • No. of pages: 845
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: November 5, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080920443

About the Editor

Louis Ignarro

Louis J. Ignarro, PhD, is Distinguished Professor Emeritus of the Department of Molecular and Medical Pharmacology at the UCLA School of Medicine. He has broad and extensive experience in the molecular and chemical biology of the nitric oxide-cyclic GMP signaling systems. He and his basic research teams have discovered and expanded the production and actions of nitric oxide in mammalian tissues, including the protective roles of nitric oxide in preventing hypertension, stroke and myocardial infarction, and its neurotransmitter role as the mediator of erectile function in humans. For these discoveries, he was awarded the Nobel Prize in Physiology or Medicine.

Affiliations and Expertise

Center for Health Sciences, UCLA School of Medicine, Los Angeles, CA, USA

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