Table of Contents

Contributors Preface Section I Overview of Basic Principles Chapter 1 Introduction and Overview Section II Principles of Biology A. Chemical Biology Chapter 2 The Chemical Properties of Nitric Oxide and Related Nitrogen Oxides Chapter 3 The Chemical Biology of Nitric Oxide Chapter 4 The Biological Chemistry of Peroxynitrite Chapter 5 A Comparison of the Biological Reactivity of Nitric Oxide and Peroxynitrite B. Nitric Oxide Synthases Chapter 6 Structural Variations to Accommodate Functional Themes of the Isoforms of NO Synthases Chapter 7 Regulation of the Expression of Nitric Oxide Synthase Isoforms Chapter 8 Molecular Regulation of Inducible Nitric Oxide Synthase Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide: A New Paradigm for Endothelial NOS Regulation by Posttranslational Modification C. Regulation of Nitric Oxide Production Chapter 10 Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role Chapter 11 Regulation of Arginine Availability and Its Impact on NO Synthesis Chapter 12 Relationship between Arginase Activity and Nitric Oxide Production D. Transport, Membrane Interactions, and Oxygen Transport Chapter 13 The Physical Properties of Nitric Oxide: Determinants of the Dynamics of NO in Tissue Chapter 14 Membrane Transport of Arginine and Cationic Amino Acid Analogs Chapter 15 The Respiratory Cycle: A Three-Gas System E. Nitric Oxide and Oxidative Stress Chapter 16 Role for Nitric Oxide and Other Radicals in Signal Transduction Chapter 17 Antioxidant Actions of Nitric Oxide Chapter 18 Mechanisms through Which Reactive Nitrogen and Oxygen Species Interact with Physiological Signaling Systems Chapter 19 Nitric Oxide, Oxygen Radicals, and Iron Metabolism Chapter 20 Re

Details

No. of pages:
1017
Language:
English
Copyright:
© 2000
Published:
Imprint:
Academic Press
Print ISBN:
9780123704207
Electronic ISBN:
9780080525037

About the authors

Louis Ignarro

Affiliations and Expertise

Center for Health Sciences, UCLA School of Medicine, Los Angeles, California, U.S.A.

Louis Ignarro

Affiliations and Expertise

Center for Health Sciences, UCLA School of Medicine, Los Angeles, California, U.S.A.

Reviews

"... for those researchers interested in the detailed biochemistry of nitric oxide and its synthesis, the book will be a very valuable reference" @source:-—TODAY'S LIFE SCIENCE @qu:"Louis J. Ignarro, pharmacologist in Los Angeles, participated in the quest for EDRF's chemical nature. He performed a brilliant series of analyses and concluded in 1986, together with and independently of Robert Furchgott, that EDRF was identical to NO. The problem was solved and Furchgott's endothelial factor identified. When Furchgott and Ignarro presented their conclusions at a conference in July 1986, it elicited an avalanche of research activities in many different laboratories around the world. This was the first discovery that a gas can act as a signal molecule in an organism." @source:--THE NOBEL ASSEMBLY, KAROLINSKA INSTITUTE, 1998