Nitric Oxide

1st Edition

Biology and Pathobiology

Editors: Louis Ignarro
Hardcover ISBN: 9780123704207
eBook ISBN: 9780080525037
Imprint: Academic Press
Published Date: 1st September 2000
Page Count: 1017
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Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.

Key Features

@introbul:Key Features @bul:* Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide

  • Authored by world experts on nitric oxide
  • Includes an overview of basic principles of biology and chemical biology
  • Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense


Researchers and students in biochemistry, cell and molecular biology, neuroscience, and pharmacology; academic clinicians in dermatology, neurology, and oncology.

Table of Contents

Contributors Preface Section I Overview of Basic Principles Chapter 1 Introduction and Overview Section II Principles of Biology A. Chemical Biology Chapter 2 The Chemical Properties of Nitric Oxide and Related Nitrogen Oxides Chapter 3 The Chemical Biology of Nitric Oxide Chapter 4 The Biological Chemistry of Peroxynitrite Chapter 5 A Comparison of the Biological Reactivity of Nitric Oxide and Peroxynitrite B. Nitric Oxide Synthases Chapter 6 Structural Variations to Accommodate Functional Themes of the Isoforms of NO Synthases Chapter 7 Regulation of the Expression of Nitric Oxide Synthase Isoforms Chapter 8 Molecular Regulation of Inducible Nitric Oxide Synthase Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide: A New Paradigm for Endothelial NOS Regulation by Posttranslational Modification C. Regulation of Nitric Oxide Production Chapter 10 Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role Chapter 11 Regulation of Arginine Availability and Its Impact on NO Synthesis Chapter 12 Relationship between Arginase Activity and Nitric Oxide Production D. Transport, Membrane Interactions, and Oxygen Transport Chapter 13 The Physical Properties of Nitric Oxide: Determinants of the Dynamics of NO in Tissue Chapter 14 Membrane Transport of Arginine and Cationic Amino Acid Analogs Chapter 15 The Respiratory Cycle: A Three-Gas System E. Nitric Oxide and Oxidative Stress Chapter 16 Role for Nitric Oxide and Other Radicals in Signal Transduction Chapter 17 Antioxidant Actions of Nitric Oxide Chapter 18 Mechanisms through Which Reactive Nitrogen and Oxygen Species Interact with Physiological Signaling Systems Chapter 19 Nitric Oxide, Oxygen Radicals, and Iron Metabolism Chapter 20 Re


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Academic Press
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About the Editor

Louis Ignarro

Louis J Ignarro is the Recipient of the 1998 Nobel Prize in Physiology or Medicine for demonstrating the signaling properties of nitric oxide. He is presently a Professor Emeritus at the Centre for Health Sciences, UCLA. His various other accolades include the 1998 Basic Research Price of the American Heart Association membership of the National Academy of Sciences, membership of the American Academy of Arts and Sciences, American Heart Association Distinguished Scientist, 2008, founder of the Nitric Oxide Society, founder and Editor-in-Chief of Nitric Oxide Biology and Chemistry, and notoriously the 'Father of Viagra'.

Affiliations and Expertise

Center for Health Sciences, UCLA School of Medicine, Los Angeles, CA, USA


"... for those researchers interested in the detailed biochemistry of nitric oxide and its synthesis, the book will be a very valuable reference" @source:-—TODAY'S LIFE SCIENCE @qu:"Louis J. Ignarro, pharmacologist in Los Angeles, participated in the quest for EDRF's chemical nature. He performed a brilliant series of analyses and concluded in 1986, together with and independently of Robert Furchgott, that EDRF was identical to NO. The problem was solved and Furchgott's endothelial factor identified. When Furchgott and Ignarro presented their conclusions at a conference in July 1986, it elicited an avalanche of research activities in many different laboratories around the world. This was the first discovery that a gas can act as a signal molecule in an organism." @source:--THE NOBEL ASSEMBLY, KAROLINSKA INSTITUTE, 1998