Nitric Oxide - 3rd Edition - ISBN: 9780128042731, 9780128043196

Nitric Oxide

3rd Edition

Biology and Pathobiology

Editors: Bruce Freeman
eBook ISBN: 9780128043196
Hardcover ISBN: 9780128042731
Imprint: Academic Press
Published Date: 24th July 2017
Page Count: 434
Tax/VAT will be calculated at check-out Price includes VAT (GST)

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs.

With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

Key Features

  • Includes perspectives from Jack Lancaster on the discovery of EDRF and nitric oxide
  • Provides detailed coverage of the new gaseous signaling agents
  • Features expanded coverage on the principles of biology, including nitric oxide synthases, nitrite and nitrate biology and pathobiology, and signaling mechanisms
  • Incorporates expanded pathobiology coverage, including nitric oxide and cardiovascular function, obesity, diabetes, and erectile function/dysfunction


Researchers and students in biochemistry, cardiology, cell and molecular biology, physiology, pathobiology, pharmacology, and endocrinology

Table of Contents

Section I. Chemical Biology
1. Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes
2. Nitric oxide redox biochemistry in lipid environments
3. Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration
4. Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes

Section II. Principles of Biology
A. Nitric Oxide Synthases
5. Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal
6. Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases
7. Regulation of the expression of inducible nitric oxide synthase
8. Molecular Regulation of Inducible Nitric Oxide Synthase
B. Guanylate Cyclase and Cyclic GMP
9. Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation
C. Nitric Oxide Signaling
10. Untargeted Discovery of NO-modified Proteins
11. Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids
12. Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1
13. The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide
D. Regulation of Nitric Oxide Production
14. Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence
E. Nitric Oxide and Remodeling
15. The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies
F. Nitrite and Nitrate
16. NO formation from inorganic nitrate and nitrite
17. Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential
18. Nitrite Therapy for Ischemic Syndromes
19. Nitrite and heme globins: Reaction mechanisms and physiological targets

Section III. Principles of Pathobiology
A. Nitric Oxide and Cardiovascular Function
20. Nitric Oxide in Vascular Damage and Regeneration
21. Free radicals as atherosclerotic risk-The relation of NO-
22. The role of oxidative stress in endothelial dysfunction and vascular inflammation
B. Pathophysiological Mechanisms of Nitric Oxide
23. Nitric oxide, oxidative stress, immune response and critical care
24. Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury
25. Nitric oxide in airway inflammation
26. Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance


No. of pages:
© Academic Press 2017
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Bruce Freeman

Bruce Freeman is a distinguished figure in the field of biochemistry. He received his PhD from University of California, Riverside, in 1978. He has since gone on to found and act as a scientific advisor for Complexa Inc and Nitromega Inc. Professor Freeman has conducted extensive research in the diefld of drug discovery, redox pharmacology, signal transduction and metabolic syndrome pharmacology. He currently holds the Irwin Fridovich Professor and Chair position at the University of Pittsburgh.

Affiliations and Expertise

Dept Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine